Astrazeneca AB jobb i Göteborg

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Scientist - Early Product Development and Manufacturing

Forskare, farmakologi
Läs mer Jul 1
At AstraZeneca, we unlock the power of What Science Can Do. Empowered to explore, every day we work towards our ultimate aim - treating, preventing, modifying and even curing complex diseases. Be part of the team where you are empowered to follow the science!

Pharmaceutical Sciences (PharmSci) is responsible for the design and development of synthetic routes, preclinical and phase I/II formulations, encompassing both small molecules and new modalities such as mRNA and oligonucleotides, across the whole range of AstraZeneca's therapeutic areas.

Within Early Product Development and Manufacture (EPDM) in Gothenburg, Sweden, the manufacturing unit is accountable for delivering a vast portfolio of early investigational medicinal products. We have a wide range of manufacturing assets in three separate manufacturing facilities, supplying different types of clinical trial material to studies across the globe.



The role

We are now seeking a new member to join our fantastic team, based at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. With employees from more than 50 countries, our Gothenburg site is a truly inspiring place to work. Within the EPDM manufacturing unit, in the GMP (Good Manufacturing Practice) arena, you will make an important contribution in delivering clinical results in the development of new medicines.

This role revolves around the manufacturing of drug product where all activities below will have a significant impact on the speed, quality and cost of the AZ development portfolio.



What you'll do

Working in the role as Scientist in EPDM and PharmSci, you will be part of an amazing group of skilled and driven colleagues who truly embrace team spirit, who you will exchange knowledge and collaborate with on many levels in various contexts. This role provides excellent opportunities for your professional development, and possibilities to take on further accountabilities in line with your personal growth.



Your main accountabilities/responsibilities:

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Assume responsibilities toward timely manufacture of various drug products in line with the plans agreed within EPDM and surrounding stakeholders.
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Work with practical hands-on processes in our GMP facilities following manufacturing batch records and perform transactions in material management systems.
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Monitor, secure and follow up on other regulatory requirements according to GMP through associated IT-systems.
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Rapidly develop strong competence within relevant process technologies and build credibility and ability to drive and secure product establishment, scale-up and clinical manufactures.
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Support documentation activities, e.g. by authoring manufacturing batch records, taking part in deviation investigations, authoring SOPs, and other guidance documents, change control processes etc.
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Assess records and report manufacturing and validation data accurately according to GMP.
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Ensure that SHE (Safety Health and Environment) and GMP standards are upheld and ensure AZ Policies and Standards are understood and followed.
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Be entrepreneurial and drive initiatives to further improve flexibility and productivity, resulting in shorter lead times or increased value for our customers and patients.



Do you have the essential qualifications for these roles?

To be successful in this role, we believe that you have a MSc in pharmacy/engineering and/or extensive GMP-manufacturing experience from the pharmaceutical industry.

We are looking for a scientist with excellent collaboration, communication, and planning skills with a strong sense of responsibility, teamwork and delivery focus. There is both scope and an expectation to build the range of accountabilities over time, in line with personal development.

Strong verbal and documentation skills in English is a requirement. We expect you to have a keen interest to learn and operate complex manufacturing equipment and develop your expertise in pharmaceutical process technology. Experience from pharmaceutical development or working in a manufacturing or supply chain organisation and knowledge of cGMP is a merit for this role.



So, what's next?

Are you already imagining yourself joining us? Good, because we can't wait to hear from you!

Welcome with your application (CV and cover letter) no later than August 19th. NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work. Interviews will be held late August.

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Business Analyst

Systemanalytiker/Systemutredare
Läs mer Aug 4
Business Analyst - Gothenburg



About the role

AstraZeneca is investing heavily in our Augmented Drug Design-Make-Test and Analyse platforms as we seek to deliver better, differentiated Candidate Drugs into trials, faster, for greater patient benefit. We have made great strides in creating the data analytics, AI, and ML services that will pave the way for this transformation. The next part of this journey will involve leveraging the current services to build new applications that will enable our scientists to design new and safer drugs faster.



We are now looking for a Business Analyst to join the team. The role will partner with the Business Relationship Manager or Business Analyst colleagues to support the development of business cases, assist in business process design and ensure that proposed solutions meet established AstraZeneca quality and compliance standards and business solution needs. Your work will have a direct impact on the science we do, and you have an opportunity to enable our scientists to undertake science not possible today.



Accountabilities

* Business Needs Identification - Operate at a functional level in assessing and defining business needs and areas for improvement. Proactively seek out opportunities to enhance and improve in line with strategic goals.
* Business Analysis Planning - Select the appropriate analysis approach to a piece of work depending on its complexity, level of risk, known assumptions, constraints and dependencies.
* Partner Analysis & Change - Identify collaborators, build and manage relationships according to individual stakeholder needs and levels of influence. Contribute to communication plans.
* Requirements Analysis and Design Definition - Responsible for requirements management plans including elicitation, approvals, processes, RAID and scope impacts.
* Business Case and Benefits Management - Support the business case definition, collect business justification for investment including return on investment and benefits realisation.
* Solution Evaluation - Analyzes and assesses solution proposals and able to articulate supporting reasoning. i.e. assessing business readiness, improving value vs. spend.
* Test Lead to define the testing approach and the components of testing to ensure traceability of requirements and efficiency of overall solution.
* Change/Communication Lead to ensure that plans and delivery support the Partner Analysis.



Requirements

To succeed, you have experience working in a regulated environment, performing business analysis and design, either alone delivering small scale business change activities; or as a contributor to a large scale or global business change. You are a communicator with strong engagement, facilitation and presentation skills, with an ability to influence others. It is important that you operate with interactive communication, demonstrating inclusion and cultural sensitivity.



We also see that you have:

* Practical usage of Agile Methodology (Scrum/Kanban)
* Jira / Confluence or similar tools
* Experience of working with third party suppliers/vendors
* Focus on customer care
* Ability to work with multiple collaborators
* Experience with planning, compliance, Business Process & Requirements Management



Pharmaceutical business domain knowledge is desireable, however not essential.



About AstraZeneca

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

SO, WHAT NEXT?

Are you up for an exciting challenge and ready for making a difference? If so, hit Apply by the 1st of September - we can't wait to hear from you!



Open date: 4/8/2022

Close date: 1/9/2022

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Director, Global Regulatory Affairs CVRM

Biolog
Läs mer Jul 5
Are you passionate about science and experienced within regulatory affairs and drug development? Do you possess strategic and operational leadership skills? Then, join us at Cardiovascular, Renal or Metabolism (CVRM) regulatory affairs to get involved in the global regulatory strategies and support the research, development and commercialization of our products across the portfolio!

AstraZeneca's pipeline of innovative medicines is consistently growing within Cardiovascular, Renal and Metabolism (CVRM). Within CVRM Regulatory Affairs we take innovative regulatory approaches to bring these CVRM life-changing treatments to those who need it - working across our early and late-stage development pipeline and the business as efficiently and effectively as possible. As an industry leading CVRM Regulatory function, we're focused and committed to the development of our products as well as to our people - providing an open and supportive space to explore, learn and develop across all regulatory roles and levels.

We are more than 65.000 people in over 100 countries. Our aim is simple to positively impact lives together. Using the power of science and innovation, our people improve the impact medicine has on patients. Together, we explore the world of science through our remarkable product pipeline and we take our understanding of the CVRM therapeutic area to a whole new level by seeking new treatments.

We continue to expand our regulatory teams at AstraZeneca's dynamic R&D sites in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden). If you are looking for a new challenge, we are offering opportunities in different disease areas and at different levels, depending on your expertise and previous experience.



What You'll do

As a Regulatory Affairs professional within AstraZeneca, you will play a key role in channeling our scientific capabilities to make a positive impact on changing patients' lives. In Regulatory Affairs, our teams influence the development of our innovative pipeline, define the regulatory strategy for our therapeutic assets, and engage with Health Authorities to effectively inform our development programs. In this way, our Regulatory Affairs teams are transforming exciting science into valued new medicines for patients around the world.

Strategic thinking is key within our function. The more experienced you are, the more accountability you will have for strategic leadership including responsibility for development and implementation of the global regulatory strategy for a product/group of products of increasing complexity.



Essential for the role

In combination with your regulatory expertise, successful candidates will demonstrate competencies of strategic thinking, strategic influencing, innovation, initiative, leadership and excellent oral and written communication skills. It is important that you embrace the concepts of novel regulatory tools and technology as well as a culture of sharing experiences with others so that the medicines that we develop will benefit from latest approaches in regulatory science. You are comfortable speaking the regulatory voice at all levels of the organization.

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Academic degree in a science related field or equivalent
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Extensive knowledge of regulatory affairs within one or more therapeutic areas in early and late development
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Proven track record of regulatory drug development including product approval/launch.
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Experience in leading Major Health Authority interactions
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Ability to think strategically and critically and evaluate risks to regulatory activities.
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Ability to work strategically within a complex, business critical and high-profile development program.



At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.



We are eager to know more about you. If you are interested to know more about us, apply now! We welcome your CV and cover letter no later than August 31, 2022.



Additional information

Curious about Regulatory at AstraZeneca?

More information about our sites:

* Cambridge, UK
* Gothenburg, Sweden
* Gaithersburg, US

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Senior Regulatory Affairs Director, Vaccines & Immune Therapies

Biolog
Läs mer Aug 9
Nytt
Are you a strategically focused Regulatory Affairs professional and would like to play an integral part in shaping drug development and gaining fast, efficient regulatory approvals? If so, read on...

At AstraZeneca, we work with diverse minds, all united by a shared passion to learn, grow and discover. The Vaccines and Immune Therapies (V&I) group at AstraZeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We are utilizing our expertise in virology, microbiology and vaccines to enable novel approaches to prevent and treat infectious disease. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules and novel biologics platforms. Within V&I Regulatory Science and Strategy, we take innovative regulatory approaches and work across our pipeline and the business to get medicines to patients as efficiently and effectively as possible.

The Senior Regulatory Affairs Director (SRAD) is accountable for the development and implementation of the global regulatory strategy for a product/group of products within the V&I portfolio. The SRAD must possess strategic leadership skills and have a deep understanding of global regulatory science and overall drug/biologic development processes and strategies for high profile, complex or novel development programs. You will provide team leadership and participate in coaching and mentorship to members of the Global Regulatory Strategy Team. You will be viewed as a senior leader within the regulatory community.





What you'll do…

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Accountable for the development and implementation of innovative global strategies of increasing complexity, and for ensuring that the strategy is designed to deliver a rapid approval with advantageous labelling in keeping with the properties of the product(s) and the needs identified by the business, and patients
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Accountable for product maintenance, supply and compliance activities associated with marketed brands
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Deliver all regulatory milestones, including the assessment of the probability of regulatory success, with risk analysis and mitigation
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Lead the objective assessment of emerging data against aspirations and update senior management on project risks/mitigation activities
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Lead the development of the global regulatory strategy document for assigned products/projects and the planning and construction of the global dossier and core prescribing information
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Provide regulatory leadership as needed in product license-in/due diligence review, product divestment and product withdrawal
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Participate in and promote novel regulatory initiatives internally and engage externally on corresponding topics as needed



Essential requirements

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Bachelor's degree in a life science or related discipline
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Substantial direct experience of working as the interface with regulatory authorities and leading delivery of regulatory projects through key milestones and investment decisions
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Broad background of experience working in several areas within regulatory affairs or therapy areas, including early and late-stage development
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Consistently demonstrating an ability to think strategically and critically evaluate risks to regulatory activities, taking account of external trends in both regulatory and business environment



Desirable requirements

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Previous experience in vaccines or immune therapies is strongly preferred
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Advanced degree in science related field and/or other appropriate knowledge/experience
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Previous experience with major regulatory authority meetings in multiple regions
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Previous experience working on due diligence activities and in a business alliance environment



Locations: Cambridge, United Kingdom; Gothenburg, Sweden, Södertälje, Sweden.



?Salary: Competitive + Excellent Benefits



So, what's next?

Are you already imagining joining our team of Global Clinical Heads? Good, because we can't wait to hear from you! Welcome with your application no later than August 31.



More information about our sites:

*

Cambridge UK
*

Gothenburg SE





Why AstraZeneca?

AstraZeneca is a global, innovation-driven biopharmaceutical company proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity. There's no better place to see what science can do.

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Associate Director, Project Information

IT-strateg
Läs mer Jul 15
At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and teamwork. Always committed to lifelong learning, growth and development!

The Associate Director, Project Information provides consultative advice to users of the system to ensure that the information required by the business (activities, cost, and value) is available for decision making at the project and portfolio level. This role is accountable of providing suave project management systems expertise in the drug development project planning process and the PLANIT tool set (Planisware and reporting). You will be responsible for coaching and training the Global Project Managers, Functional Project Managers and GPPM-led project teams in program and project management techniques available within the PLANIT tool set to facilitate the delivery of project objectives.

The working environment is fast paced and to be successful in the role you have previously worked on multi-functional teams and can easily adapt your way of communicating with different stakeholders to build relationships. You have a solid understanding of the Drug Development Process and its different stages and functions.

Major Duties and Responsibilities

* Identification of process/tool issues and recommended solutions
* Development and management of PLANIT Business Processes
* Monthly Reference Line Process
* Project Base-lining
* Portfolio and Business Update Review Process
* Business requirement collection of changes required to the system based on organizational or continuous improvement efforts, e.g.:
* Managing changes e.g. Organizational changes (RBS), PLANIT template changes, Algorithm changes, data quality, training users etc.
* Ad Hoc PLANIT consultancy when Global Project Managers and Functional Project Managers need advice on how to complete a task within the PLANIT system or through a PLANIT process related to their project

Requirements/Qualifications:

System software/Portfolio Management

* Knowledge of project management as a subject area including the ability to build, coordinate, and maintain an integrated product plan and to control or respond to changes in strategy and scope.
* Expertise in use of enterprise-wide pharmaceutical project management software solutions, including skills in critical path analysis. MS Project and/or Planisware experience is required in a Pharmaceutical/Biotech environment.
* General understanding of financial and resource planning systems and processes and ability to coordinate project-level budget/resource estimates and lead actuals vs. plan.
* Experience with reporting software such as PowerBI and Business Objects is a plus.
* A level of knowledge/awareness of the overall biologic/pharmaceutical product development process, including stages of development and role of different functional areas.
* Working in multi-functional teams

Other Experience/Abilities

* Must be professional, dedicated, and detail-orientated and have the flexibility to travel domestically and internationally.
* Excellent oral and written communication, interpersonal, analytical, and digital literacy.
* Demonstrated organizational skills required, including good time management skills and the willingness to work independently.

Leadership Capabilities Required

* Commitment to Customers & Integrity
* Focuses on what is important: balances and prioritizes across diverse and competing customers, needs and opportunities. Demonstrates the courage to make tough decisions about where to invest time and energy
* Acts Decisively
* Takes calculated risk: makes effective decisions despite uncertainty and/or incomplete information to drive business outcomes. Communicates clearly to ensure alignment and empowers others with decision-making authority as appropriately
* Works Collaboratively
* Encourages Diverse Thinking: creates an environment in which diverse viewpoints are sought and encouraged both within and beyond the team
* Drives Accountability
* Holds others accountable: Communicates clear expectations of behavior and outcomes as well as why these standards matter. Holds others accountable for delivering them

This is a phenomenal opportunity to contribute to advances within the area of Project Information and systems! Role can be adapted depending on seniority of applicant.

Welcome with your application, no later than August 21, 2022.



Additional information:

Our site in Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg.html

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Clinical Pharmacology Expert in CVRM

Forskare, farmakologi
Läs mer Jul 29
Do you have expertise and experience in clinical pharmacology, PK, PKPD, Model Informed Drug Development (MIDD) and its application in drug development? Would you like to apply your expertise in a company that is following the science and turn ideas into life changing medicines? If yes, we have the position for you at AstraZeneca!

We now have an exciting opportunity for an engaged and diligent individual to join our growing Clinical Pharmacology and Quantitative Pharmacology (CPQP) team at AstraZeneca at our vibrant Gothenburg site in Sweden, as a Senior Scientist, Associate Director or Director depending on your background, experience and skills.

This is a global role that will support large- and small molecule projects across all phases of clinical development within the therapy area of Cardiovascular, Renal and Metabolism.

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. Within the Clinical Pharmacology and Safety Sciences (CPSS) function at AstraZeneca, we have a state-of-the-art Clinical Pharmacology and Quantitative Pharmacology (CPQP) organization with a diverse and uniquely skilled team of clinical pharmacometricians, clinical pharmacology scientists and other experts. You will thrive in an energising environment where challenging work goes hand in hand with development. With opportunities, recognition and bright minds, there's no better place to unlock learning and build a long-term career. Gothenburg is a key research and development location for our Cardiovascular, Renal and Metabolism area.

What you will do

Working closely with clinical pharmacometricians, physicians and other scientists, you will apply your expertise and leadership skills to contribute to the strategy of the clinical development program and the design and interpretation of clinical studies. You will influence key decisions in early and late phases of clinical development.

In collaboration with clinical pharmacometricians, you will represent CPQP in cross-functional project teams, and be responsible for developing the clinical pharmacology strategy. The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. You will take part in finding opportunities to apply model informed drug development to accelerate and advise decision making. Based on your interest, skills and experience, you might also perform some pharmacokinetic and pharmacometrics modelling and simulation acting as a dual Clinical Pharmacometrician/Clinical Pharmacologist. You will communicate your findings within and outside of AstraZeneca and publish in peer reviewed journals.

Minimum requirements for the role

* PhD or equivalent (M.Sc/Pharm.D.) in clinical pharmacology or other relevant area
* Good knowledge of pharmacokinetics, PKPD and Clinical Pharmacology
* Biological understanding of disease and drug action
* Good oral and written communication skills

Desirable in the role

* 3+ years of industry experience or equivalent in pharmacokinetics and clinical pharmacology in drug development
* Track record in creating and delivering on clinical pharmacology strategies of both small and large molecules
* Early and late phase clinical development experience
* Good knowledge and experience in use of PK and PKPD modelling and its clinical application
* Recognized clinical pharmacology expertise as demonstrated by scientific publishing in the field of clinical pharmacology

We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your skills, abilities and contribution. You have a real passion for your subject, along with a collaborative nature and ability to work in multi-disciplinary global teams.

Why AstraZeneca?

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. Collaborate in an inclusive environment, a place full of bold new opportunities. Be empowered to be innovative and creative where difference is valued.


So, what's next! Does this sound like your next challenge? Apply today!

We look forward to find out more about you. Send in your application as soon as possible, we will review applications continuously.

For more information about the position please contact the hiring managers, Angelica Quartino (https://www.linkedin.com/in/angelica-quartino-352a7b2/) or Ann-Charlotte Egnell (https://www.linkedin.com/in/lotta-egnell-9595b0a/)

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg site: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Read more about BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

#DataAI

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Clinical Pharmacometrician in CVRM

Forskare, farmakologi
Läs mer Jul 29
Do you have expertise and experience in PK and PKPD, mathematical/statistical modelling and simulation, Model Informed Drug Development (MIDD) and its application in drug development? Would you like to apply your knowledge in a company that is following the science and turn ideas into life changing medicines? Then this might be your next challenge!

We now have an exciting opportunity for an engaged and diligent individual to join our growing Clinical Pharmacology and Quantitative Pharmacology (CPQP) team at AstraZeneca at our vibrant Gothenburg site in Sweden, as a Senior Scientist, Associate Director or Director depending on your background, experience and skills.

This is a global role that will support large- and small molecule projects across all phases of clinical development within the therapy area of Cardiovascular, Renal and Metabolism.

Within the Clinical Pharmacology and Safety Sciences (CPSS) function at AstraZeneca, we have a state-of-the-art Clinical Pharmacology and Quantitative Pharmacology (CPQP) organization with a diverse and uniquely skilled team of clinical pharmacometricians and clinical pharmacology scientists. You will thrive in an environment that inspires innovation, encourages multidisciplinary team-working and collaboration with academia, and rewards original scientific thinking.

What you will do
Working closely with clinical pharmacologists, physicians, statisticians and other scientists, you will apply model informed drug development (MIDD) to contribute to clinical programs, to support the design and interpretation of clinical studies and influence key decisions in early and late clinical development.

The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. Use of simulations and pharmacometric/statistical analyses to inform trial and program designs and decisions are important focus areas for us.

In collaboration with clinical pharmacologists, you will represent CPQP in cross-functional clinical project teams and be responsible for identifying and executing model informed drug development opportunities, to accelerate and inform decision making. Based on your interest, skills and experience, you might also take on strategic planning and delivery of the clinical pharmacology strategy acting as a dual Clinical Pharmacometrician/Clinical Pharmacologist. You will communicate your findings within and outside of AstraZeneca and publish in peer reviewed journals.

Minimum requirements for the role

* PhD or equivalent (M.Sc. or Pharm.D.) in pharmacometrics or mathematical/statistical modeling and simulation or other relevant area
* Strong technical knowledge and hands-on skills in modeling and simulation
* Biological understanding of disease and drug action
* Good oral and written communication skills

Desirable in the role

* 3+ years of industry experience or equivalent in quantitative modelling and its application in drug development
* Track record in creating and delivering on MIDD strategies in clinical drug development programs for both small and large molecules
* Early and late phase clinical development experience
* Understanding of clinical pharmacology aspects of drug development, preferably in both a small and large molecule setting
* Recognized scientific expertise demonstrated by scientific publishing in the field of clinical pharmacology

We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your skills, abilities and contribution. You have a real passion for your subject, along with a collaborative nature and ability to work in multi-disciplinary global teams.

Why AstraZeneca?

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. Collaborate in an inclusive environment, a place full of bold new opportunities. Be empowered to be innovative and creative where difference is valued.

So, what's next? If the sounds like the job and place for you - apply today!

We look forward to find out more about you. Send in your application as soon as possible, we will review applications continuously.


For more information about the position please contact the hiring managers, Angelica Quartino (https://www.linkedin.com/in/angelica-quartino-352a7b2/) or Ann-Charlotte Egnell (https://www.linkedin.com/in/lotta-egnell-9595b0a/)

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg site: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Read more about BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

#DataAI

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Sr. Research Scientist/Assoc. Principle Scientist

Organisk kemist
Läs mer Aug 4
Senior Research Scientist or Associate Principle Scientist- Isotope Chemistry



At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.



Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API).



We are now looking for a Senior Research Scientist or an Associate Principle Scientist to join our Isotope Chemistry Team, part of Early Chemical Development, in Gothenburg.



The Isotope Chemistry Team delivers high-quality tritium, C-14, and stable isotope labeled compounds through the use of novel chemistry, innovative routes, and creative solutions. The laboratory is a companywide asset for the non-GMP manufacture of radiolabeled and stable isotope labeled compounds. It supports projects from target identification to single compound selection to clinical phases and post marketing support for all therapy areas in the portfolio.



The isotope chemistry team supports the projects with the highest priority and urgent needs in the AZ portfolio and has access to top-quality labs and equipment.



The role

As a member of the team, you will work closely with scientists in drug projects to develop safe, efficient, and cost-effective synthesis routes to labeled drug candidates and tool compounds.



Key Deliverables:

* With strong emphasis on safety, health, and environmental aspects, explore and develop experimental strategies, troubleshoot problems, and synthesize labeled organic molecules.
* Plan, prioritise, and perform own work and actively collaborate with the drug project teams.
* Demonstrate expertise in synthetic and analytical chemistry, as well as, purification techniques.
* Provide stringent documentation of experimental results in an electronic lab journal.
* Publish novel work in peer reviewed journals.



Experience

* A Ph.D. degree or equivalent in Organic Chemistry
* Strong collaborative and communication skills.
* Previous work with radioactivity is not required.



Key qualities:

* Strong theoretical and practical knowledge of organic chemistry, with good awareness of current developments in the literature
* Ability to independently design, plan, and execute multistep syntheses
* Creativity in handling a wide range of synthetic challenges
* Ability to coach peers for improved individual and team performance and development
* A good communicator with experience in interacting effectively across disciplines
* Work collaboratively across boundaries
* Curious and innovative



Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.



Welcome with your application by the 25th of August.



Open date: 4/8/2022

Close date: 25/8/2022



Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

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Senior Scientist / Associate Principal Scientist

Kemist
Läs mer Jul 13
Do you have a passion for science with a background in LC-MS bioanalysis and would like to apply your knowledge in a company that turns ideas into life changing medicines? Then this role at AstraZeneca might be right for you!


We are now recruiting a Senior Scientist or Associate Principal Scientist in Bioanalysis to join the Drug Metabolism and Pharmacokinetics (DMPK) department within the Early Cardiovascular, Renal and Metabolism therapeutic area (CVRM). The role is located at AstraZeneca's vibrant R&D center in Gothenburg, Sweden.

The DMPK bioanalysis team delivers fundamental understanding of drug disposition, which includes bioanalysis of drug candidates in biological samples generated in non-clinical studies. The data generated provides insight to quantitative pharmacology as well as right tissue and right exposure aspects, including the fate of drug substances and metabolites. This role will continue to build our capability in bioanalysis with focus on oligonucleotides, peptides, PROTACs, and small molecules, among others.


Early CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate what science can do. DMPK interacts with many functions in supporting CVRM projects along the value chain, from target selection all the way to launch and life cycle management. We thrive in a place where the bright and curious minds seamlessly come together in our inclusive environment. Join us to be part of developing future treatments for Cardiovascular, Renal and Metabolic diseases.


What you'll do
With a passion for science, you will support our growing portfolio in the CVRM disease area. You will develop quantitative methods for novel drug candidates and provide pharmacokinetic data to projects from target identification to life-cycle management. This lab-based role can be at Senior Scientist or Associate Principal Scientist level depending on the experience of the successful candidate.

Typical accountabilities in your daily work will include:

* Quantify drug candidates and their metabolites in various in vitro and in vivo samples to support PKPD (Pharmacokinetics and Pharmacodynamics) work in projects from early stage of drug discovery & development to life cycle management
* Identify new workflows and technologies to improve our ways of working aligned with drug project needs
* Communicate data and guidance to project representatives, act as an example to/for other scientists, and contribute to the overall team delivery.
* Plan and report all work to appropriate standards (Good Laboratory Standard, GLS) and keep project teams appraised of findings
* Write manuscripts and publish research together with external/internal collaborators


Essential for the role
The successful candidate is expected to have hands-on experience with LC-MS and sample preparation (e.g. different enrichment workflows, protein precipitation, LLE (Liquid Liquid Extraction), SPE (Solid Phase Extraction), and immunoprecipitation)
* PhD in a relevant discipline or MSc with equivalent experience.
* Experience of development and application of quantitative bioanalytical methods
* Good knowledge of liquid chromatography and mass spectrometry (LC-MS)
* Ability to work in cross-functional teams as well as independently
* Excellent oral and written communication skills in English


Desirable for the role
* Previous experience of quantification of oligonucleotide drugs such as antisense oligonucleotides (ASO) or small interfering RNAs (siRNA)
* Experience of lab automation
* Experience of high-resolution mass spectrometry
* Experience with other analytical technologies such as PCR, and immunoassays
* Basic understanding of DMPK
* Understanding of the overall drug discovery and development process.
* Publications in a relevant field


So, what's next?
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!
For more information about the position please contact hiring manager Mikko Hölttä, Mikko.Holtta@astrazeneca.com. Welcome with your application no later than August 26, 2022.



Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

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Business Support Coordinator

Administrativ assistent
Läs mer Jul 29
Are you an admin professional that finds motivation in supporting others? Would you love a flexible work where you get the opportunity to play a meaningful role for our Senior Leaders every day? Then, join us at AstraZeneca and Development Operations.



Development Operations brings together all the skills groups to drive critical operational activities for early and late stage medicines development. We are nearly 2,500 people operating in more than 45 countries across the globe - partnering with the early and late Therapeutic areas to meet the demands of extensive clinical trial programmes involving many thousands of patients.



We are now looking for a new Business Support Coordinator to join the team, reporting to the Business Support Manager. The position can be based at either of our sites in Gothenburg or Warsaw.



The role as Business Support Coordinator is a phenomenal opportunity to take on a challenging and varied role within our admin team. Your focus will be on providing high quality professional administration support to senior leaders within Development Operations. You will be working proactively together with the other co-ordinators in the function and possibly also more broadly within BioPharmaceuticals R&D. To be successful in the role you have experienced from working in a global complex environment and customer service is something you like in your every day job. .



Your accountabilities:

* Provide support to senior leaders, coordinating complex meetings and off-site events, diary arrangements and travel in line with AZ policy
* Work collaboratively with Global Colleagues to deliver a lean, consistent and professional global support service, including knowledge sharing and training within the Business Support team
* Be an expert in using technology to efficiently complete tasks and propose technology based solutions
* Control projects under general guidance ensuring delivery of project outputs according to plan, reviewing and refining plans as necessary

* Independently and pro-actively resolve issues and challenges, ensuring delivery of day-to-day support activities and programs
* Prepare documents, materials and official information releases and distribute to the required stakeholders
* Plan, organize, and schedule own workload, so that all activities are completed accurately and on time while using and developing best practices



Essential requirement for the role:

* Significant administrative or related experience
* Good communication and coordination skills
* Experience with a variety of virtual meeting technologies, information management software, and Microsoft products
* Ability to manage multiple projects/tasks/assignments simultaneously and effectively
* Demonstrated skills and ability in PC applications
* Strong customer service skills
* Independent follow-up on action items from meetings
* A high degree of personal credibility when interfacing with organizations internal and external to AZ
* Experience working in a fast-paced global environment



Desirable experience for the role:

* Experience of working in a pharma or healthcare environment
* Experience managing SharePoint sites including creating and managing permission groups, creating new sites, and adding design elements



So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.



We welcome your application by August 19th at the latest.



Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

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Senior Scientist - High-content imaging and assay development

Forskare, farmakologi
Läs mer Aug 5
Are you an experienced scientist in the field of high-content imaging and advanced analysis? Would you like to combine your scientific skills & curiosity to establish robust assays with human stem cell-derived in vitro models of disease and elucidate novel disease mechanisms? This might be the next challenge for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in the Applied Stem Cell Sciences team in Translational Genomics, Discovery Sciences, Biopharmaceuticals R&D, as a bench-based Senior Research Scientist to be a key player in developing high-content imaging based assays using advanced cell models.

The role

Working alongside our stem cell scientists, disease area specialists, genome editing group, and computational biology experts you will have the opportunity to work on scaleable cellular models in multiple indications to design and execute complex cell-based assays for target validation and mid-throughput screens for target identification.

The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude.

Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.


Key Skills and Responsibilities:

* MSc/PhD degree with significant experience in Neuroscience or Cell Biology
* Minimum 3+ years experience in using automated (e.g. Yokogawa, Molecular Devices) and conventional fluorescent and confocal imaging systems (e.g. Zeiss, Nikon)
* Demonstrable skills across a broad range of image analysis and data analytics tools (Cell Profiler, ImageJ, Spotfire)
* Design and execute complex cell-based assays and mid-throughput screens using imaging-based readouts as well as other readouts as needed
* Troubleshoot batch effects, imaging protocol selection, cell- and compound-dispensing, data acquisition and instrument scheduling
* Collaborate effectively with Quantitative Biology and Machine Learning teams to optimize image analysis strategies, statistical analysis and model building

The following skills are highly desirable:

* Familiarity with human 2D and 3D cellular assays using primary or hiPSC-derived cells types.
* Experience with setting up cell-based pharmacological assays
* Familiarity with arrayed genetic screens including CRISPR-based approaches
* Experience with automated liquid handling systems (i.e., Bravo, Tecan, Hamilton or similar) and lab automation in context of cell-based screening

Why AstraZeneca?

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. With more than 2,800 employees from over than 60 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So what's next? If this sounds like the next job and place for you, apply today!

We look forward to get to know you better - please send your application to us as soon as possible, but no later than 28th August, 2022.

For more information about the position please contact Bilada Bilican at bilada.bilican(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

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Business Support Coordinator - GPPM

Chefssekreterare
Läs mer Jul 15
Are you an experienced and pro-active administrator who has worked in a large global organization looking to join a vibrant team in Global Portfolio and Project Management at AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and teamwork. Always committed to lifelong learning, growth and development! We will always make sure you're clear about how your role is connected to our wider mission to show what science can do!

Our vibrant campus in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we've built a series of environments where innovation can happen.

You will be a key member of the Global Portfolio and Project Management team (GPPM) using your excellent organizational and social skills to enable leaders in our Project and Portfolio Management fields to work optimally in a dynamic enterprise environment to ensure delivery of GPPM's short-term goals and longer-term strategic priorities.

Typical Duties & Responsibilities:

Coordination of the BioPharmaceuticals Therapeutic Area Leadership Teams (TALT)

* Includes setting annual TA meeting calendar and TA strategy, individual meeting arrangements, meeting preparation, ownership and maintenance of distribution lists, and information management (SharePoint Online, incl. MS Teams)
* End-to-end management of TALT meeting scheduling, set-up, execution and closure, including but not limited to:
* Issue and update of calendar invites
* Collation, distribution and storage of meeting materials such as pre-reads & final slide decks ensuring consistency in document format, file naming conventions and archives
* Arranging meetings globally and take care of all the logistics
* Support for communications and official information releases, plus distribution to required partners
* Active improvement and standardization of administrative processes

Personal Assistant Support

* Full and complex diary management for two Executive Directors, including scheduling global meetings, flagging conflicts and meeting prioritization
* Arranging business travel and visas as required
* Processing expense claims for senior leaders
* Responding on behalf of Executive Director group to different partners maintaining high professional standards whilst meeting conflicting needs
* Responding to more complex or escalated inquiries from other PA/secretarial staff

Skills & Experience:

Being a confident individual, you will enjoy working with partners across all levels of our organization, in different time zones and with people from many cultures. Having experience of coordinating cross-functional teams, you are used to working independently and enhancing administrative processes. You are a problem solver. The sophisticated diary arrangements will require you to have strong influencing skills with the ability to engage relevant people globally in developing solutions; your patience and flexibility will be highly advantageous. Confidentiality is paramount.

Essential

* Prior experience supporting senior managers in a fast-paced company setting
* Strong interpersonal skills
* Experience in establishing and maintaining collaboration across senior leaders' community
* Proficient in oral and written English and with excellent communication skills
* Proven track record to develop knowledge in relation to administrative/business support activities in the relevant area
* Experience with Microsoft Office software and centralized data systems/platforms e.g. for document storage, travel booking and expense management

Desirable

* Project or governance coordination/ administration experience. Understanding of the AstraZeneca project operating model.
* Experience of working with a project management or portfolio management team.
* Relevant vocational qualifications or equivalent experience
* Team leadership skills

What´s next?

Are you already imagining yourself joining our team? Good, because we are looking forward to seeing your application before the 21 Aug.

Additional information:

Our site in Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg.html

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Discovery Safety Scientist/Senior Scientist, In Vitro Biology

Molekylärbiolog
Läs mer Aug 4
Are you a motivated cell biologist with experience of in vitro work in molecular biology, omics, high content cell imaging? Do you also enjoy working hands-on in the lab with a great group of colleagues by your side? If yes, this might be the next position for you!

Right now, we are looking for 3 highly engaged and enthusiastic cell biologists to join as a Discovery Safety Scientist or Senior Scientist, depending on your background and experience, and complement us in our In Vitro Safety group, which is part of Respiratory & Immunology, NeuroScience, Vaccines & Immune (RINVI) Therapies Safety, at AstraZeneca in Gothenburg, Sweden.

By joining the in vitro safety team in the RINVI safety group at AstraZeneca you will be exposed to a highly dynamic and challenging work environment that will allow you to adapt and expand your in vitro experience to application of safety challenges within the drug discovery process. You will have access to advanced in vitro technologies and be encouraged to work in an independent, science-driven manner. You will also join a diverse team of engaged and friendly scientists from a broad variety of backgrounds.

What you'll do:
Working in an industry-leading safety organization you will design and complete experimental strategies to predict, assess and mitigate target- and drug-related safety risks in drug discovery and development programs and develop mechanistic understanding behind (potential) safety concerns. You will propose, develop and integrate novel in vitro safety assays and technologies to drive our predictive scientific capabilities for drug safety, with a focus on the Therapeutic Areas Respiratory & Immunology, NeuroScience and Vaccines & Immune Therapies.

You will use your experience as a cell biologist to work independently and as part of a team. You will champion in vitro based science and technology innovations to develop our strategic capabilities including collaborating with other engaged scientists across the organization and with leading academic institutes, publish in high quality journals and actively contribute to scientific field networks.

Who you are:

The ideal candidates will have a passion for in vitro lab based experimentation and analysis and value the utility of early drug safety investigations. We are looking for someone with strong communication and collaboration drive, who can adopt a brave and forward thinking approach to drive our predictive in vitro safety assay design to support drug discovery and development projects.

Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.


Essential for the role:

* PhD in biology, biotechnology, toxicology or pharmacology or a related field.
* Strong background in mammalian cell biology and in vitro work in molecular biology, omics, high content cell imaging and other technologies such as western blot, ELISA, FACS.
* Experience of complex in vitro cell models, MPS systems or Spatial transcriptomics would be desirable.
* Experience in the culture of primary neurons, astrocytes and microglia, and human iPSC neurons is essential for one of the positions.
* Track record of scientific delivery, evidenced by impactful publications, establishing collaborations, delivering successful funding proposals.
* Strong communication skills: including presenting, manuscript preparation, influencing and building partnerships with internal and external research groups.

Why AstraZeneca?
With more than 2,800 employees from over 60 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So, what's next?
If this sounds like the job and place for you - apply today!
We look forward to get to know you better. Send in your application as soon as possible, but no later than 5th September, 2022.
For more information please contact Paul Fitzpatrick, Associate Director - Respiratory & Immunology Safety Science, at paul.fitzpatrick2(at)astrazeneca.com.

Additional information
Our AstraZeneca Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Make a move to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

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Senior Medical Communication Manager

Forskare, farmakologi
Läs mer Jul 21
We are looking for strategically-minded innovative individuals with strong clinical, collaboration, and organizational skills to join our Global Medical Information team at the vibrant site in Gothenburg, Sweden.

Exciting opportunity to work in a team that has a broad scope of work in the medical information and medical communication space. We are always innovating and striving for excellence in medical communications to help improving patients' lives.

What you'll do

Medical information at AstraZeneca is responsible for the strategic planning, development and implementation of medical content and communication for health care professionals using various channels, including digital, to support patient care. A combination of global and US remits provides the opportunity to collaborate internationally and drive strategically-aligned and consistent medical communication.

The Senior Medical Information Manager is responsible for the proactive planning, development of scientific content to support Medical Affairs, providing scientific consult, review & approval of promotional materials, and answering medical inquiries from healthcare professionals to bring value to our customers and ultimately the patient. Additionally, this role empowers forward-thinking and digital innovation to help drive efficiencies and engaging scientific exchange.

Responsibilities

General

*

Strategic application of scientific and business expertise relevant to therapeutic areas, including products, disease state management, emerging therapies, and the competitive landscape
*

Collaborate with key collaborators to strategically plan and implement scientific information development and dissemination to meet customer needs
*

Supervise the medical environment and apply expertise, coordinated with regulatory/compliance landscape, and local markets' knowledge to impact Brand/Therapeutic Area strategy
*

Contribute to processes related to MI operations, drive operational excellence, and support digital innovation through forward and innovative thinking to meet business needs efficiently

Scientific Content/Brand Partnership

*

Strategically lead and/or provide oversight of others in the development, review and maintenance of communication materials for various channels (e.g., MI requests, digital, Field Medical) in collaboration with Medical Affairs for global and US market
*

Represents Medical Information within the promotional review cross functional team by:
*

Providing strategic scientific consults on brand messages
*

Reviewing promotional materials for content, accuracy, and final MI approval
*

Collaborating across the business to ensure promotional and non-promotional materials are strategically aligned
*

Provides guidance for the use of AZ products by reviewing resources developed by external compendia (e.g. evidence-based practice centres, treatment guidelines, Medical Letter)

Customer Engagement

*

Provides oversight of others and/or responds to medical information inquiries from Health Care Providers via multiple channels
*

Delivers accurate, focused, and scientifically balanced clinical and scientific information exchange with healthcare providers that support the appropriate use of AstraZeneca products.
*

Identify, analyse and report trends in medical and scientific insight (including medical inquiries) to Medical Affairs partners and assess the need to update or build scientific materials (standard responses, slide decks, and Q&As;).

Essential

*

Post graduate qualification in medical/scientific field (e.g., PharmD, MD, PhD, MPharm or equivalent)
*

Drug/medical information experience gained in pharmaceutical industry or comparable experience with the healthcare/clinical/hospital environment
*

Experience in scientific literature evaluation and analysis
*

Experience in medical writing
*

Strategic problem solver with eye for business (optimally influence and interact with cross-functional colleagues) and organizational skills

Desirable

*

Promotional medical review experience
*

Medical communications/content creation (e.g., slide decks) experience
*

Digital strategy oriented attitude and experience
*

Project management experienc
*

Experience in applying regulatory (e.g. FDA, EMA), legal, and compliance requirements to Medical Affairs activities and drug information delivery



Why AstraZeneca

At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what's next?

Welcome with your application no later than August 22nd.



Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

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Solution Architect - Late Science

IT-arkitekt/Lösningsarkitekt
Läs mer Jul 26
Solution Architect - Late Science

Do you have expertise in Solution Architecture and a passion for patient centric clinical trials, digital regulatory submission management, and innovations in digitizing business workflow? If so, this position may be just for you! We have an exciting opportunity for someone who wants to guide how technology can enable AstraZeneca to scale patient centric clinical trials, automate document generation and transform regulatory submission management. As a Solution Architect within the Clinical Development and Regulatory architecture group, you will be responsible for the direction, performance and ongoing health of the solution architecture within the Clinical Development and Regulatory Portfolio of Products and Business Processes.

About AstraZeneca

At AstraZeneca, we are united by a common purpose: to push the boundaries of science to deliver life-changing medicines. This purpose underpins everything we do. Our work helps to make hearts healthier, to help people breathe easier, and to help more people survive cancer. Every single day, we make a difference by delivering potentially life-changing medicines to millions of people worldwide and by leading breakthrough science that promises to transform the treatment of disease. Our IT delivery into the R&D functions is at the heart of making this possible.

About the role

As a Solution Architect, you will specialize in digital architecture development supporting business and IT strategic objectives across the of programs and products which includes clinical study team, clinical data analytic teams and external clinical personnel facing applications. In addition, we work closely to develop strategic digital transformations of the applications supporting our Regulatory and Submission teams to accelerate toward increased digital registrations, increase exploitation of data platforms and visualizations. You will ensure that architectures delivered, both logical and physical, are aligned with AstraZeneca architecture standards, blueprints and roadmaps. You will create and review architecture designs and build a balance between immediate business requirements and long term strategic plans. You will also be instrumental in the interpretation of current architecture and define and update future architectures applying AstraZeneca architecture guiding principles. The Solution Architect will be accountable for driving solution evaluation, selection decisions, buy vs build decisions and proof-of-concept projects and advise on business case development.

You will also:

* Partner with collaborators across Enterprise Architecture, IT Stakeholders and the Business
* Work with Business Analysis and Solution Engineering functions and supports functional & technical requirements management, including driving software selection processes
* The Solution Architect will partner with project managers, business analysts, and solution engineers to build solutions that are aligned to AstraZeneca architecture standards and principles, leverage common solutions and services, and meet the financial targets (cost and benefits).
* Provide technical & IT expertise support to project teams and conduct AZ architectural reviews throughout project lifecycle
* Ensures compliance with existing EA guidelines and standards (e.g. AZ Architecture Engagement Process (ISPMM) and EA Software Standards)
* Contribute to project and service teams in the development, implementation and maintenance of standard architectural components
* Work with third party suppliers as required and contribute to the creation of local or functional design documents

The role may require some travel, both domestic and international.

Key skills and experience

To succeed in this role you are a highly motivated self-starter and an independent problem solver who thrives in finding creative and innovative solutions. You have demonstrable experience and technical expertise in the creation and deployment of solutions involving multiple technology stacks/layers, software and system integrations and large data sets. This role also needs someone who has exceptional interpersonal and communication skills with ability to interpret and communicate highly technical concepts into business language.

We also see that you have:

* Degree or equivalent number of years of experience in Computer Science, Engineering, or Data Management related fields
* Knowledge of clinical research, clinical trial, healthcare delivery, GxP processes and other regulations within pharma industry
* Experience with one or more cloud platforms (AWS, Azure, Google)
* Experience in industry architectural patterns and frameworks
* Understands conventional and forward-thinking clinical data structures
* Experience in learning new business domains, processes and capabilities
* Agile solution design and agile project delivery

WHY JOIN IT?

R&D IT within AstraZeneca is a network of innovative, forward-thinking individuals who work to reimagine technology delivery within the framework of a science-driven company. Thought leadership and innovation are what drives us to explore and execute new ways of working and new ways of using technology to deliver life-enhancing, life-saving therapies to our patients world-wide.

SO, WHAT'S NEXT? Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours.

Open date: 26/7/2022

Close date: 20/8/2022

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Scientist, Patient Centered Science

Biomedicinare
Läs mer Aug 1
It's our patients that come first, every decision we make and action we take is centred around how we can better serve them. It's why we are shaping patient care for the future, working along the whole experience to give hope to billions of lives across the world. Do you want to join us on our journey?

Our vision in the Patient Centered Science (PCS) team at AstraZeneca is to s to positively impact lives by amplifying the patients' voice in healthcare decision-making.

We seek to identify, measure, understand and communicate patient experience of disease and treatment including symptoms, health status and health-related quality of life. Using qualitative and quantitative research as a foundation, PCS incorporates the patient journey into research to serve the needs of our patients.

We are now looking for a Scientist to join our PCS team at our vibrant R&D site in Gothenburg, Sweden

What we do

The PCS function is a global team of 20 people that share the passion for including the patient perspective in drug development. We are a diverse group that enjoys leading and developing the field of patient centered science and we love to work together and have fun at work.

Our team plays a pivotal role in challenging AstraZeneca's scientific capabilities to make a positive impact on changing patients' lives and include patient perspective into drug development.

What you'll do

As a PCS Scientist you will work closely with PCS Directors and study teams to implement Patient Reported Outcomes (PRO) and other Clinical Outcomes Assessments (COA) into clinical trials to ensure high quality evidence supporting products regulatory approval, reimbursement and commercialization. In the role you will be driving efficient implementation of PRO into studies, with the following activities:

* To translate the patient experience strategy into a fully implemented program
* Lead PCS function interactions with internal and external teams to apply strategy at the study level to oversee PRO implementation and under supervision, contribute to the development of patient centered measurement strategies that meet the needs of key stakeholders including the patient
* Drive the everyday work of COA implementation in studies and have responsibility for the scientific aspect of the electronic capture of COA (eCOA) implementation
* Support development of relevant PRO/COA training materials for patients, investigators and monitors
* Ensure appropriate standards are applied and participate in development of new standards and assist with review of results and the preparation of regulatory documents
* Draft Clinical Study Protocol (CSP) text based on the pre-defined patient experience strategy
* Draft PRO (Statistical Analysis Plan) SAP text

You will interact with internal AstraZeneca teams and externally with PCS strategic partners, linguistic validation and eCOA providers, with regulatory authorities and key external experts.

The role is dedicated to support our Cardiovascular, Renal and Metabolic (CVRM) therapeutic area and will require an in-depth understanding of patient-centered outcomes research within the context of pharmaceutical development.

Essential for the role

* University Degree in Life Sciences, clinical, Information Technology, social sciences or equivalent
* Familiarity with clinical research from industry or CRO work experience
* Experience with PRO development and usage in clinical studies is preferred but not required
* A PhD or relevant experience from research within the field of Life Science is preferred but not required
* Able to implement projects including interactions with stakeholders
* Good written and verbal communication skills
* Ability to define clear scope of projects and provide support
* Integrity and high ethical standards

We believe that you are a team player who believes in "we" being greater than "me". You share our curiosity to learn on the job and you are humble about the fact that we can't know it all.

So, what's next?

Join a talented and agile team that focus on what really matters. We're inspired by the direct link between what we do, how this helps to accelerate the business and, ultimately, how this benefits peoples' lives across the world.

Are you already imagining yourself joining us? Good, because we can't wait to hear from you.

Welcome with your application, no later than August 21, 2022.

Why AstraZeneca

At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality.

We know that our work impacts people with serious conditions, many of whom have no other alternatives. That's what drives us - the potential to impact over one billion patients worldwide.

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

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Senior Full Stack Engineer

Mjukvaruutvecklare
Läs mer Jul 22
AstraZeneca are looking for Senior Full Stack Engineers to help build and enhance our next generation Drug Discovery platform! We are investing heavily in our Augmented Drug Design-Make-Test and Analyse (DMTA) platforms as we seek to deliver better, differentiated Candidate Drugs into trials, faster, for greater patient benefit. We have made great strides in creating the AI and ML toolsets that will pave the way for this transformation and platforms supporting new therapeutic modalities. The next part of this journey will involve firming up our existing toolsets and building the applications that will enable us to maximise the value of our new technologies in bringing small molecule and other therapeutic modalities (e.g. peptides, oligonucleotides and conjugates) through the funnel.

In Early Science, we have highly skilled scientists generating ideas and performing experiments in the support of complex drug discovery projects. Our environment is driven by scientific and technical innovation with a high degree of diversity in workflows, data, vendor solutions and in-house builds.

About the role

Working alongside Software and Data Engineers, Architects and other IT and science partners, you will devise technical solutions, estimate and deliver high value returns in our DevOps teams to some of the most challenging issues slowing down innovation. You will utilize your technical acuity to troubleshoot and provide innovative solutions to ensure smooth experiences for our users, as well as make recommendations with peers on how we can move forward. Your work will have a direct impact on the science we do, and the opportunity to enable our scientists to undertake science not possible today.

We're an expanding global development team which is migrating as close to as we can to a true DevOps model. The Portfolio is a mixture of unique self-developed and Commercial Off the Shelf Software (COTS) solutions. It's a siloed environment and you have the challenge and opportunity to make the back end systems and front end user experience seamless in a realm of dynamic requirements and needs.

Responsibilities

The role is accountable for ensuring that best practices are followed in the constant software development struggle of juggling between legacy and pioneering, as well as offering forward thinking ideas and solutions to continually close that gap.

You will:

* Work with pods of engineers, distributed across multiple locations that consistently and iteratively delivers high-impact, high-quality solutions while maintaining high quality operations
* Work across legacy systems and brand new in all aspects such as the data layer, middleware, application, UI, and everything in between
* Work with project teams integrating new software with old, in house with COTS, and making the suggestions that have an impact on those ratios, and thus the platform itself
* Advocate and advance modern, agile software development practices and help develop and promote a vibrant software engineering culture
* Mentoring and providing feedback to more junior engineers

Requirements

* Deep expertise in languages like Java, with the willingness and ability to quickly ramp up on new ones as required
* Experience in at least one major development framework, from Spring to Lagom and beyond
* Strong front end skills using JavaScript and demonstrable experience in a front end framework like Vue.js, or React. Additional skills in CSS as well as some related CSS framework like Bootstrap, or TailwindCSS
* Solid experience in relational and/or No databases (bonus points for Oracle, Postgres, and/or Cassandra)
* Proficiency in *nix environments
* High proficiency in data structures and design patterns, as well as associated anti-patterns. Be able to defend, compare, and contrast these decisions
* Experience in cloud services and tools (e.g. AWS services such as S3, Redshift, lambda, DMS)
* Excellent unit testing practices using proper software architectures to make those tests possible
* CI/CD experience with some automation tooling like Jenkins, TravisCI, Bitbucket Pipelines, etc
* Experience of data analysis - profiling, investigating, interpreting and documenting data structures,
* Attention to detail and the ability to follow standards while contributing to the evolution of standards themselves
* Excellent teamworking skills
* Excellent verbal and written communication skills
* A critical thinking approach and the capacity to propose solutions, not just highlight problems
* The desire to engineer rather than just write code
* An always learning, never complacent demeanour when it comes to what you do best

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.



So, what's next? Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours. Hit Apply today!

Open date: 2022/07/22

Close date: 2022/08/15

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible.

Ansök nu

AI Engineer

Systemutvecklare/Programmerare
Läs mer Jul 15
AI Engineer

Do you have expertise in, and passion for AI? Would you like to apply your expertise to impact the Enterprise Reusable AI team in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!



Role:

We are seeking an AI Engineer to accelerate AstraZeneca's ambition of putting AI at the heart of 80% of our key business processes by 2025. The ideal candidate will have broad industry experience, having worked on a wide range of different ML disciplines, and be capable of applying sophisticated mathematical and quantitative expertise to a range of impactful data science and software solutions. The role will work to use foundational and pioneering techniques to manipulate complex data structures in combination with business domain knowledge, and develop advanced and impactful AI that unlocks significant business and scientific insights for the company.

Working as part of a distributed team of AI Engineers and technical specialists, you will have the opportunity to develop and deploy AI algorithms throughout the delivery lifecycle, from ideation, PoC, MVP to cloud production. This will involve rapidly prototyping ideas in response to complex problem statements, formulating and working on scalable ML pipelines, and partnering with other AI scaling engineers to build reusable AI assets and services that are shared throughout the Enterprise.

The ideal candidate will be strong at both machine learning and software development, able to apply and tune innovative algorithms in response to problem statements and write production and industry leading code in partnership with others. They will ideally have experience working as part of agile development teams and be entrepreneurial, spotting and acting on opportunities to innovate and unlock value.



Key Accountabilities:

* Guide in a broad range of AI/ML fields and be able to use software to respond to and solve complex business and research problems; research and develop advanced AI models.
* Translate and formulate unstructured business problems into the appropriate data problem, model and analytical solutions.
* Contribute towards and help maintain cloud ML pipelines across a portfolio of projects.
* Perform AI research, including establishment of hypotheses that can be approached using computational methods and tools. Present or publish findings for conferences and in peer reviewed journals where appropriate.
* Build effective relationships with established range of partners to ensure utilization and value of information resources and services. Clearly and objectively communicate results, as well as their associated uncertainties and limitations within agreed frameworks.
* Develop, maintain and apply ongoing knowledge and awareness in trends, standard methodology and new developments in analytics and data science.



Candidate Knowledge, Skills and Experiences:

* Bsc/MSc/PhD degree in Mathematics, Statistics, Computer Science or related quantitative field.
* Experience in the modelling of complex datasets in applied business and/or scientific application domains, resulting in the development of innovative AI algorithms and applications.
* Advanced software development skills in at least two standard data science languages (Python is essential) and familiarity with database systems (e.g. , No, graph)
* Understanding of algorithm design, optimization, scaling and applications.
* Hands-on experience in the Python ecosystem for data science, machine learning and AI (Scikit-learn, Pytorch, Tensorflow, Numpy, Pandas).
* Experience developing, deploying and maintaining APIs.
* Thorough understanding of classical mathematical and statistical concepts such as regression, inference, sampling, Bayesian methods, and optimization.
* Working knowledge of cloud environments and experience writing AI software as part of agile delivery teams.
* Proven expertise in software development standard methodologies and principles (software architecting, linting, CI/DI, unit tests, OOP, Git).
* Excellent written and verbal communication, business analysis, and consultancy skills.
* Strong bias for action and results.



WHY JOIN IT?

We're a network of entrepreneurial self-starters who contribute to something far bigger. There's a diversity of expertise in our Technology group that's unique to AstraZeneca - it allows us to dive deep into exploring new groundbreaking technology. We enable AstraZeneca to perform at its peak by delivering world-class technology and data solutions. Our work unlocks the potential of science.

Technology at AstraZeneca is a home for purposeful disruptors!



SO, WHAT'S NEXT?

Are you already imagining yourself joining our team? Good, because we'd love to hear from you! Click the link to apply and we'll be in touch as soon as we can.

Competitive salary & benefits on offer.



Open Date: 15/7/2022

Close Date: 14/8/2022



NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Principal AI Platform Engineer

Mjukvaruutvecklare
Läs mer Jul 18
Principal AI Platform Engineer



Do you want to use your expertise to make an impact on advancing the standard of healthcare, and improve lives across the globe? Then this role might be for you!



About the role

We are looking for a Principal AI Platform Engineer to join our Enterprise AI Platforms and Operations Team. The Enterprise AI Platforms and Operations Team are responsible for building and running the platforms, tooling and infrastructure that powers AstraZeneca's ambition to use AI in every step of the value chain, from discovering new compounds to patient safety systems.

We achieve this through a combination of technical leadership and agile focused development, continuously evaluating the fast-moving advancements in Machine Learning tooling for challenges across AstraZeneca's R&D, Commercial and Operations domains. We deliver these tools through easy to access development environments that allow AstraZeneca's Data Scientists and Machine Learning Engineers to focus on building groundbreaking solutions for patients at scale.



You will be part of a collaborative team of multidisciplinary engineers and together have the chance to create tools that will advance the standard of healthcare, improving the lives of millions of patients across the globe. Our data science platforms will support major AI initiatives such as clinical trial data analysis, knowledge graph analytics, patient safety systems, deep learning led drug discovery, software as a medical device system.

As a Principal AI Platform Engineer with an interest in building complex systems, you will be responsible for inventing how we use technology, machine learning, and data to enable the productivity of AstraZeneca. You will help build, deploy and develop our next generation of platforms and tools at scale.





Key Accountabilities

* Collaborate with Data Scientists and Machine Learning Engineers from across the company to understand their challenges and work with them to build the platform that underpins their research.
* Be a part of a hard-working agile team, continuously improving AstraZeneca's Machine Learning development environments, platforms and tooling
* Work closely and collaboratively with internal governance and compliance functions such as Cyber Security and Data Privacy to secure our estate without obstructing end-user productivity.
* Adapt standard machine learning methods to best exploit modern parallel environments (e.g. distributed clusters, multicore SMP, and GPU).
* Champion a "production first mindset" to ensure the necessary infrastructure and platforms are available to scale exploratory research to production.



Candidate Knowledge, Skills & Experience

* BSc/MSc/PhD degree in Computer Science or related quantitative or analytical field
* Solid experience working with AWS or equivalent cloud
* Experience working with Kubernetes and container-based applications
* Experience in administering a production cluster, with an understanding of operators, storage classes and service meshes
* Experience building and delivering software using the Python programming language, exceptional ability in other programming languages will be considered
* Demonstrable experience deploying the underlying infrastructure and tooling for running Machine Learning or Data Science at Scale using Infrastructure of Code
* Experience working in an Agile team
* Experience working with internal security standards and frameworks
* Experience working with GxP compliant life science systems will be looked upon favourably
* Experience leveraging DevOps to enable automation strategies
* Creative, collaborative and resilient.



Why join us

Join us at a crucial stage of our journey in becoming a digital and data-led enterprise. Make the impossible possible by building partnerships and ecosystems, creating new ways of working and driving scale and speed to deliver exponential growth. Focused and committed, and backed with the investment to succeed, we're driving cross-company change to disrupt the entire industry.



SO, WHAT NEXT?

Are you up for an exciting challenge and ready for making a difference? If so, hit Apply today - we can't wait to hear from you!



Competitive salary & benefits on offer.

Open Date: 22 / 07 / 2022

Close Date: 15 / 08 / 2022



NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Associate Director - Pharmacovigilance Auditor - Audit QAL

Kemist
Läs mer Jul 14
Do you have expertise as a Pharmacovigilance Auditor? Do you have a passion for promoting and optimising quality and efficiencies? Do you enjoy providing data-driven insights? Would you like to apply your expertise to ensure that quality is a key factor in AstraZeneca's sustainable business success? Then this role might be the one for you!

About AstraZeneca
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.

Locations
Gothenburg,Sweden, Warsaw, Poland, Cambridge, United Kingdom.

Business area
As the independent second line assurance function for R&D, our mission in Quality Assurance is to achieve enduring excellence in auditing, quality management, quality risk assessment and enhance the R&D quality approach for the benefit of our patients.

R&D QA commits to provide our partners with an experience that is driven by patient protection and data integrity, represents regulators current and future views, optimises quality thinking and promotes a 'right from me' approach, focuses on issues that matter, minimises risks and drives inquisitive outcomes and provides simple, structured and efficient systems, with up-to-date quality information.

Come and join our AZ team where you will play a pivotal role in this exciting period of development!


What you'll do

*

Lead, guide and support the execution of Pharmacovigilance quality assurance audits.
*

Evaluate risk and standards and quality principles including coordinating and facilitating inspections globally.
*

Orchestrate and facilitate critical audits for core GxP areas, including Good Clinical practice, Good Pharmacovigilance Practice and Good Regulator Practice, investigator audits, system or process audits, and vendor audits to support inspection readiness and success.
*

Assess the need for corrective and preventative action. Facilitate the development of Corrective and Protective Action ("CAPA") plans deemed necessary by Quality Assurance lead team members.
*

Assist in leading the development and revision of Quality Assurance processes and procedures.
*

Assess and communicate relevant industry information and changes regarding compliance to colleagues and clients.
*

Work collaboratively with Quality Assurance team members, as well as external consultants, running regulatory inspections, conducting outsourced audits, and providing internal training as needed.


Required Experience, Skills, and Qualifications

*

Bachelor's degree or foreign equivalent in one of the medical sciences (Medicine, Pharmacy, Biology, Chemistry), plus five (5) years of experience designing, conducting, leading and participating in regional and global Pharmacovigilance ("PV") Audits. Alternatively, a Master's degree or foreign equivalent in a related field of study, plus two (2) years of experience as a PV Auditor.
*

25% national and international travel is required to various company and client sites.
*

Monitoring adherence and resolving non-compliance with company policies and applicable regulations including ICH, GCP, and 21 CFR.
*

Performing ad-hoc for cause audits to identify or confirm suspected non-compliance and assist with root cause identification.
*

Managing tools to track, trend, and report GVP audit data.
*

Excellent analytical, written and oral communications skills.
*

High ethical standards, honest, operating with absolute discretion.
*

Strong collaborative, influencing and interpersonal skills - curious to understand business environment.


Desired requirements

*

Experience in leading regulatory health authority GxP Inspections
*

Project management experience
*

Skilled at managing & using various types of technology
*

Ability to maintain and create professional networks with collaborators


Why AstraZeneca
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.

So, what's next:
Are you already envisioning yourself joining our team? Good, because we can't wait to hear from you. NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible.

Closing date: 14th August, 2022.

Ansök nu

Postdoc Fellow: Disease Modelling in NAFLD/NASH

Driftledare, IT
Läs mer Aug 3
AstraZeneca is a global, science-led, patient-centred biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we 're dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There's no better place to make a difference to medicine, patients, and society.

Postdoc Fellow: Disease Modelling in NAFLD/NASH

Location: Gothenburg, Sweden



Are you curious to find out more about how mathematical modelling can help shape drug development? Would you like to explore how disease modelling in non-alcoholic steatohepatitis (NASH) will improve the design and development of future clinical trials? Then don't miss out on this postdoc opportunity at AstraZeneca.



About AstraZeneca:



AstraZeneca is a global, science-led, patient-centred biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we 're dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There's no better place to make a difference to medicine, patients, and society.



About the Postdoc Programme:



Bring your expertise, apply your knowledge, follow the science, and make a difference.



AstraZeneca's Postdoc Programme is looking for self-motivated individuals eager to tackle exciting, high impact projects in a collaborative, engaging and innovative environment. As a Postdoc Fellow at AstraZeneca, you will be part of a group of passionate researchers who are dedicated to innovation and the advancement of science. You'll work with peers and professionals from a diverse group of backgrounds, and a world class academic mentor specifically aligned to your project. You will be empowered to share your findings at research conferences and in publications, and establish valuable networks which support your research and future career development!



Our Postdoc Programme will also support you to further develop your skills as a scientist.



About the Team:



In this postdoc position you'll join our clinical pharmacology and quantitative pharmacology cardiovascular, renal and metabolism (CPQP CVRM) team. In CPQP our focus is on determining the optimal dose of medicine our patients should receive, based on efficacious disease treatment and patient safety. Using modelling tools, we integrate available clinical and non-clinical data to quantitatively support decision making during drug development.



CPQP is part of the larger clinical pharmacology and safety sciences (CPSS) organisation at AstraZeneca. CPSS is a collaborative, global R&D department with colleagues based in the UK, US & Sweden who bring together capabilities and expertise in Drug Safety, Regulatory Safety, Pathology, Clinical Pharmacology, Quantitative Systems Pharmacology and Animal Sciences. CPSS supports all AstraZeneca therapy areas from early stage to late stage drug discovery.



About the Opportunity:



In this exciting Postdoc position you'll improve the design and evaluation of future clinical NAFLD/NASH trials by developing a framework to predict NAFLD/NASH disease progression using external clinical cohorts, pharmacometric methodology and fit-for-purpose machine learning techniques.



You'll join a wide network of experts in the fields of NASH, mathematical modelling and clinical development. You'll benefit from a unique selection of clinical longitudinal non-alcoholic fatty liver disease (NAFLD) cohorts and build upon mathematical models already developed in house.



This is a novel and innovative research project supported by two partnering functions within AstraZeneca R&D, and also guided by renowned academic experts in the field of NAFLD/NASH. The nature of this project also means that you can expect broad exposure to other functions involved in the drug development process. This unique opportunity will therefore provide you with an overview of how strategic directions are set and how decisions are made and influenced by clinical pharmacology and quantitative pharmacology during drug development.



The network of internal and external experts will help you to publish high impact publications and develop your research reputation. You may also get the opportunity to mentor more junior researchers.



Qualification, Skills & Experience



Required:

* PhD in Applied Mathematics, Statistics, Pharmacometrics or a related field
* Programming experience within R/Matlab
* Experience with applied statistical modelling
* Excellent communication and collaboration skills
* Curious and passionate about using quantitative methods to advance medicine



Desirable:

* Hands-on experience of working with biological or clinical data
* Experience in longitudinal, mixed effects and/or Markov modelling
* Scientific excellence as shown by previous work, publication list or references from scientific mentors
* Prior understanding of the drug-development process



Apply today!



Advert Opens: 4th August, 2022

Advert Closes: 11th September, 2022

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Senior Data Scientist in Image Analysis

Systemutvecklare/Programmerare
Läs mer Jul 12
Are you motivated by using your image analysis skills to drive scientific R&D in drug discovery and are seeking a role where your expertise can make an extraordinary impact? This is an opportunity to join a dynamic and enthusiastic environment, whilst delivering critical support to drug discovery projects.

Artificial Intelligence (AI) and data science methods are transforming all sectors and industries. In the Data Sciences and Quantitative Biology department, within Discovery Sciences, we are combining these methods with domain knowledge and biological expertise to make life-changing medicines and change patients' lives. Join a place built on innovation and creativity!

We are looking for a Senior Data Scientist in Image Analysis to join our team at our vibrant AstraZeneca R&D site in Gothenburg, Sweden. This position is located within the Data Sciences & Quantitative Biology department - a global, diverse and delivery focused department where we collaborate to support drug projects striving to impact patients' lives.

As a Senior Data Scientist in Image Analysis, you will be focusing at the early stages of drug discovery, working with imaging assays (2D, 3D, complex models, kinetics, etc) and analysing cellular images captured with microscopes (fluorescently stained or bright field samples). You will develop and apply image and data analysis methods to answer biological questions, from tailored to high throughput experiments. You are able to seek opportunities and influence at all levels, from lab biologists to business leaders, and engage externally via publications and conference presentations. We expect you to be equipped with modern image processing methods in image segmentation, pattern recognition and other machine learning and AI methods.

What you will do

You will be working closely with experimental and biological colleagues, in the design, application and interpretation of image processing algorithms and downstream data processing projects. You will be primarily working with cellular images captured under wide-field and confocal microscopes (fluorescent stained or bright field); nonetheless, you may also support image processing tasks from other image modalities when opportunities arise. Typical tasks include image segmentation, quantification, enhancement, reconstruction, clustering and classifications. In addition, you will be working closely with biologists, chemists and scientists from other disciplines, and you will need to communicate quantitative concepts and data to non-experts in a clear and concise way to enable and influence decision-making. Given the interdisciplinary nature of this role, you are also expected to have some understanding of, or the interests to learn about, cell biology and cellular screening workflows.

Responsibilities:

* Use image and data analytical methods, to work with drug discovery projects and therapeutic areas to identify and deliver solutions for addressing key biological questions
* Build and internalise algorithms and techniques to define and answer questions using suitable software packages from in house developed tools, open source packages and/or commercial vendor software
* Ensure that results are scientifically robust
* Communicate your work to non-experts and business leaders to move projects forward and influence decision-making
* Discover and define gaps in data and knowledge for ongoing projects, extract internal/external data and methods, and work with discipline specialists to fill the gaps
* Contribute to and lead local and global projects
* Promote AstraZeneca's image and data analysis capabilities and reputation through external publications and presentations

Essential for the role

* B.Sc., Masters or PhD or equivalent in a relevant field (computer science, electronics, electrical engineering, physics, mathematics or equivalent) with relevant experience
* Image processing knowledge and experiences in such as image segmentation, classification, clustering, enhancement and reconstruction
* Mathematics and data science knowledge and experience of using and applying either machine learning (deep learning), statistical modelling or multivariate profiling methods to analyse image data
* Interest in or basic understanding of cell biology
* Skilled in Python (TensorFlow/Keras, PyTorch), R, MATLAB or other relevant programming languages

Desirable for the role

* Experience in working with large quantities of image data
* Experience in combining image data with other data modalities
* Experience in working with 3D,temporal image and/or other complex image data.
* Hands on experience with microscopic software and hardware such as CellProfiler, ImageJ/FIJI, PerkinElmer's Columbus, Yokogawa's CV7000/CV8000
* Working with biologists in an experimental and cellular-screening environment
* Interests and experiences in assay development and experimental design using statistical tools and methods

Why AstraZeneca Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centres. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work.

So, what's next?
Send in your application as soon as possible, but no later than the 9th of August 2022. We will review applications continuously.

#DS&QuBi;

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Clinical Regulatory Writers

Biolog
Läs mer Jun 22
Are you a passionate Medical Writer with Clinical and Regulatory authoring experience? Can you envision using your expertise to impact patients' lives? Join our Clinical regulatory Writing department to make a purposeful difference!

At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

We have a range of Clinical Regulatory Writing opportunities available across the early and late portfolio - including Director, Associate Director and Manager roles - and we want you to join us!

As a team, we author clinical and regulatory documents that align with project strategies, regulatory requirements and communications best-practices. We support AstraZeneca's core therapeutic areas in all phases of clinical development, playing a key part in delivering medicines to patients most in need as swiftly as we can.

Whichever role you're successful in, you'll be joining an extraordinary team with an outstanding record of achieving successful submissions and approvals.



Essential for the role

We believe that you hold a Bachelor's degree in life sciences at a minimum, and if you have a MSc or PhD, this will be an advantage. Your education is further complemented by regulatory writing experience from the pharmaceutical industry. Collaboration is key and you have a track record of running fruitful and effective partnerships, both internally and externally. We also believe that you share our passion for applying medical writing expertise to reach our goal to change lives.

*

Solid understanding of the clinical drug development process with experience in integrating information from all phases of clinical development into clinical and regulatory documents and submissions
*

Extensive knowledge of current regulatory guidelines relating to regulatory communications
*

Consistent display of ability in project management, thinking (conceptual, analytical and integrative), influencing and team working
*

Flexibility in adapting to changing circumstances or new information



The recruitment process will follow the below steps:

*

Application and CV review 30 minute screening call with a senior member of the team
*

Completion of a medical writing exercise
*

Final interview



Why AstraZeneca?

Work with curious minds in an inclusive culture. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

We strongly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your skills, abilities and contribution.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.



So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.

This application period is open until August 31st, 2022 and we will be reviewing and interviewing continuously. Please include both CV and motivation letter in your application



Where can I find out more?

?Global Gothenburg: https://www.youtube.com/watch?v=JcPhZ6DobFA

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

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Senior Regulatory Affairs Director - V&I

Biolog
Läs mer Jun 22
Are you a strategically focused Regulatory Affairs professional and would like to play an integral part in shaping drug development and gaining fast, efficient regulatory approvals? If so, read on...

At AstraZeneca, we work with diverse minds, all united by a shared passion to learn, grow and discover. The Vaccines and Immune Therapies (V&I) group at AstraZeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We are utilizing our expertise in virology, microbiology and vaccines to enable novel approaches to prevent and treat infectious disease. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules and novel biologics platforms. Within V&I Regulatory Science and Strategy, we take innovative regulatory approaches and work across our pipeline and the business to get medicines to patients as efficiently and effectively as possible.

The Senior Regulatory Affairs Director (SRAD) is accountable for the development and implementation of the global regulatory strategy for a product/group of products within the V&I portfolio. The SRAD must possess strategic leadership skills and have a deep understanding of global regulatory science and overall drug/biologic development processes and strategies for high profile, complex or novel development programs. You will provide team leadership and participate in coaching and mentorship to members of the Global Regulatory Strategy Team. You will be viewed as a senior leader within the regulatory community.



What you'll do…

*

Accountable for the development and implementation of innovative global strategies of increasing complexity, and for ensuring that the strategy is designed to deliver a rapid approval with advantageous labelling in keeping with the properties of the product(s) and the needs identified by the business, and patients
*

Accountable for product maintenance, supply and compliance activities associated with marketed brands
*

Deliver all regulatory milestones, including the assessment of the probability of regulatory success, with risk analysis and mitigation
*

Lead the objective assessment of emerging data against aspirations and update senior management on project risks/mitigation activities
*

Lead the development of the global regulatory strategy document for assigned products/projects and the planning and construction of the global dossier and core prescribing information
*

Provide regulatory leadership as needed in product license-in/due diligence review, product divestment and product withdrawal
*

Participate in and promote novel regulatory initiatives internally and engage externally on corresponding topics as needed



Essential requirements

*

Bachelor's degree in a life science or related discipline
*

Substantial direct experience of working as the interface with regulatory authorities and leading delivery of regulatory projects through key milestones and investment decisions
*

Broad background of experience working in several areas within regulatory affairs or therapy areas, including early and late-stage development
*

Consistently demonstrating an ability to think strategically and critically evaluate risks to regulatory activities, taking account of external trends in both regulatory and business environment



Desirable requirements

*

Previous experience in vaccines or immune therapies is strongly preferred
*

Advanced degree in science related field and/or other appropriate knowledge/experience
*

Previous experience with major regulatory authority meetings in multiple regions
*

Previous experience working on due diligence activities and in a business alliance environment



Locations: Cambridge, United Kingdom; Gothenburg, Sweden

?Salary: Competitive + Excellent Benefits



So, what's next?

Are you already imagining joining our team of Global Clinical Heads? Good, because we can't wait to hear from you! Welcome with your application no later than August 31



More information about our sites:

*

Cambridge UK
*

Gothenburg SE



Why AstraZeneca?

AstraZeneca is a global, innovation-driven biopharmaceutical company proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity. There's no better place to see what science can do.

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Cheminformatics specialist

Kemist
Läs mer Jul 5
Are you a Cheminformatics specialist with an interest in working closely with chemists and biologists in a hit identification environment? Would you like to make use of your informatics skills to provide expert advice and push the boundaries of science to make a change? If so, join our journey to develop and deliver novel medicines!

As our new Cheminformatics specialist you will be a part of the Hit Discovery department in Discovery Sciences. The role has a special focus on new technology development and application in the area of hit identification and automated chemistry and you will be based at AstraZeneca's R&D site either in Gothenburg, Sweden or Cambridge, UK.

Discovery Sciences is part of the global BioPharmaceuticals organisation and provides scientific support to early drug discovery across the global discovery portfolio. The Hit Discovery department is responsible for the discovery of novel chemical hits in four principal areas: High-throughput screening, Fragment-Based Lead Generation, DNA-encoded libraries, and Virtual Screening, augmented by automated chemistry and AI/machine learning.

What you'll do:
Key elements in the role as Cheminformatics specialist include the exploitation and adaptation of cheminformatics technology to support the work and the data handling of chemists and biologist in hit discovery and automated chemistry.

You will apply and adapt cheminformatics software and science in the fields of Automated Chemistry, HTS, DNA-encoded libraries and Virtual Screening to support compound and data handling, reaction informatics, analysis and learning from data. As well as devise, champion and develop the scientific area of Cheminformatics that aligns with the Automated Chemistry group and Hit Discovery department missions. You will provide expert advice and interpretation of complex data.

Essentials in the role:

* PhD in the area of Cheminformatics or Computational Chemistry with several years of experience combined with profound technical skills like computer programming and systems design, or a degree in Computer Sciences with demonstrated additional knowledge and experiences in a relevant area of science, as chemistry, physics, or biology.
* Demonstrated experience with a variety of software tools and technologies (e.g., Java, C++, Python/Ruby/Perl, , or AWS).
* Experience within a research-based scientific computing environment.
* Experience of developing and maintaining relationships with 3rd party collaborators and software providers.
* Excellent knowledge of modern computational chemistry/computer science methods and algorithms and its use in drug hunting projects.

We also believe that our new colleague are a team player with the ability and enjoys to work in a multidisciplinary research matrix environment, providing scientific leadership and insights to the team.

Desirable in the role:

* Good understanding of how the drug discovery process functions within discovery and how computational methods contribute to and influence projects.
* Ability to identify new opportunities to impact and influence also outside own project responsibilities.

Why AstraZeneca?
Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area.

So, what's next? If this sounds like the job and place for you to make a change - apply today!

We look forward to get to know you better. Please send your application to us no later than 16th August.

For more information about the position please contact hiring manager Jens Sadowski at +46 31 7762850.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Our Cambridge site: https://www.astrazeneca.com/our-company/our-locations/cambridge.html
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

NOTE - Due to our summer vacation period during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Computational Chemist/Computer Scientist

Kemist
Läs mer Jul 5
Are you a Computational Chemist/Computer Scientist with an interest in the exploitation of virtual screening technology? Would you like to make use of your computational skills to provide expert advice and push the boundaries of science to make a change? If so, welcome to join our AstraZeneca journey!

We are looking for a Computational Chemist/Computer Scientist to join us and be a part of the Hit Discovery department in Discovery Sciences. In this role you will get the opportunity to put a special focus on new technology development and application in the area of virtual chemistry and virtual screening. The role will either be based at AstraZeneca's R&D site in Gothenburg, Sweden or in Cambridge, UK.

The Hit Discovery department is responsible for the discovery of novel chemical hits in four principal areas: High-throughput screening, DNA-encoded libraries, and Virtual Screening, augmented with automated chemistry and AI/machine learning. As part of the broader Discovery Sciences function you'll also play a part in the global BioPharmaceuticals organisation that provides scientific support to early drug discovery across the global discovery portfolio.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you'll do:
In the role as Computational Chemist/Computer Scientist you will focus on the development and exploitation of novel computational and cheminformatics technology for use by medicinal and computational chemists across Discovery. You will also develop, apply and lead technology development and science in the field of Virtual Screening and Molecular Modelling with a proven impact on projects through the development of tools that improve the hit identification and hit creation capabilities of computational and medicinal chemists.

To devise, champion and develop the scientific areas of computational chemistry that aligns with the Hit Discovery department mission is also included as responsibilities. The role holder will be a leader in the discipline and make significant contributions to the practical delivery of project goals and we expect you to be able to provide expert advice and interpretation of complex data.

Essentials in the role:

* PhD in the area of Computational Chemistry with several years of experience combined with profound technical skills like computer programming and systems design, or a degree in Computer Sciences with demonstrated additional knowledge and experiences in a relevant area of science, as chemistry, physics, or biology.
* Demonstrated development experience with a variety of programming languages, tools, and technologies (e.g., Java, C++, Python/Ruby/Perl, , or AWS).
* Experience within a research-based scientific computing environment.
* Experience of developing and maintaining relationships with 3rd party collaborators and software providers.
* Excellent knowledge of modern computational chemistry/computer science methods and algorithms and its use in drug hunting projects.

It's also preferred to have the ability to identify new opportunities to impact and influence also outside own project responsibilities. You should also be able to work and collaborate in a multidisciplinary research matrix environment, providing scientific leadership and insights. And a good understanding of how the drug discovery process functions within discovery and how computational methods contribute to and influence projects is a plus.

Why AstraZeneca?
Join the team that follows the science unlike anywhere else. This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs. Always advancing our scientific knowledge and helping to shape the future of healthcare for the greatest and swiftest impact on disease.

So, what's next? If this sounds like your next challenge - apply today!

We look forward to get to know you better. Please send your application to us no later than 16th August.

For more information about the position please contact hiring manager Jens Sadowski at +46 31 7762850.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Our Cambridge site: https://www.astrazeneca.com/our-company/our-locations/cambridge.html
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

NOTE - Due to our summer vacation period during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Senior Scientist/Principal Scientist - Integrated Bioanalysis

Analytisk kemist
Läs mer Jul 5
Are you an experienced scientist with a background in analytical biochemistry that holds expertise of developing mass spectrometric methods for the quantitative measurement of biotherapeutics? Do you also want to work in an excellent team with a common goal to push the boundaries of science? If yes, welcome to join our exciting journey at AstraZeneca!

Right now, we are seeking a passionate Senior Scientist/Principal Scientist to join our Integrated Bioanalysis function at our vibrant R&D site in Gothenburg, Sweden. The person taking on this position will take a lead role in the lab designing bioanalysis method strategies and interpreting data generated in support of new modality projects that will advance our drug pipeline.

You are working in the Discovery Bioanalysis Europe team which is part of the Clinical Pharmacology and Safety Sciences (CPSS) organisation and is responsible for the analysis of nucleotide, protein, monoclonal antibody and gene and cell therapeutics and non-clinical safety biomarkers in biological and invitro samples generated in support of non GLP pharmacokinetic, pharmacodynamic and investigational safety studies. We have a diverse array of scientists working across many technologies to ensure delivery of critical assays and data analysis that drive go/no go decisions and ensure the right combination of medicines get to the right patient, in the right dose, at the right time

What you'll do:
In this scientifically focused role you will lead large, nucleotide and small molecule mass spectrometry pharmacokinetics and biomarker activities in the laboratory to better understand drug actions and their association with pharmacodynamics and safety.

Your principle responsibility will be in the lab, designing, developing, and interpreting assays to support drug program transition through lead candidate selection. Representing the department on multidiscipline drug development teams, thus ability to support other technologies in the lab, especially ligand binding assays, will be a benefit. You will report into a head of Discovery Bioanalysis EU and be encouraged to take a lead role in pushing the boundaries of what is possible for mass spectrometry based bioanalyses in determining lead drug candidates.

Essential in the role:

* A strong background in analytical biochemistry / chemistry with extensive experience of developing mass spectrometric methods for the quantitative measurement of biotherapeutics such as antibody drug conjugates, peptides, proteins, nucleotides and small molecules.
* Experience with chromatographic separation of various analytes by liquid chromatography.
* Great knowledge with the development, troubleshooting and qualification of quantitative pharmacokinetic assays for drug measurement in various biological matrices (e.g. plasma, urine, tissue homogenate).
* Proficiency with mass spectrometry and proteomic software.
* A high level of independence and with an ability to develop hypotheses and complete analysis plans for pharmacokinetics, pharmacodynamics and proteomics biomarker data.

To be successful in the role we also believe that you enjoy collaborating across a multidiscipline drug discovery organisation with ability to communicate in a good way as well as think and act creatively and independently. Being attentive and outstanding record keeping skills are also essential for success.

Desirable in the role:

* Experience with advanced data analysis tools for analyzing and visualizing pharmacokinetic and biomarker data.
* Operational experience with broader measurement technologies such as ligand binding and PCR for measurement of proteins and nucleotides.
* A proven track record of publication in large molecule bioanalysis field.

Why AstraZeneca?
Join the team that follows the science unlike anywhere else. This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs. Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.

So, what's next? If this sounds like the job and place for you - welcome to apply today! We look forward to your application, but no later than 14th August, 2022.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38

NOTE - Due to our Summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Integrated Bioanalysis - Senior Scientist

Biolog
Läs mer Jul 5
Are you a passionate scientist who enjoys working in the lab and have experience of technologies such as PCR, ligand binding, branched-DNA and hybridisation ELISA? If yes, this position might be the next challenge for you!

Welcome to join us in the Integrated Bioanalysis function at AstraZeneca in Gothenburg, Sweden as a Senior Scientist with Integrated Bioanalysis expertise. You will be working in a multidiscipline drug discovery team and will be designing bioanalysis method strategies and interpreting data generated in support of new modality projects that will advance our drug pipeline.

The role sits in our Discovery Bioanalysis Europe team which is part of the Clinical Pharmacology and Safety Sciences (CPSS) organisation. We are responsible for the analysis of nucleotide, protein, monoclonal antibody and gene and cell therapeutics and non-clinical safety biomarkers in biological and in-vitro samples generated in support of non-GLP pharmacokinetic, pharmacodynamic and investigational safety studies. We have a diverse array of scientists working across many technologies to ensure delivery of critical assays and data analysis that drive go/no go decisions and ensure the right combination of medicines get to the right patient, in the right dose, at the right time.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you'll do:
Using a range of innovative analytical methodologies, this position will work to develop novel quantitative bioanalysis methods for the pharmacokinetic measurement of therapeutic gene editing, protein, monoclonal antibody and nucleotide therapeutics. Your focus and principle responsibility will be in the lab, designing, developing, and deploying assays and then interpreting the data generated to support drug discovery program transition through to lead candidate selection.

In the role you will also represent the department on multidiscipline drug discovery teams spanning a number of different therapeutic modalities, thus ability to utilise a range of technologies in the lab will be essential such as PCR, ligand binding, branched-DNA and hybridisation ELISA.

Essential in the role:

* A strong background in a biological or chemical related discipline with extensive experience of developing methods for the quantitative measurement of biotherapeutics such as therapeutic gene editing, monoclonal antibody, nucleotides and proteins.
* Experience with the development, troubleshooting and qualification of quantitative pharmacokinetic assays for drug measurement in various biological matrices (e.g. plasma, urine, tissue homogenate).
* A high level of independence and with an ability to develop hypotheses and execute analysis plans for pharmacokinetics, pharmacodynamics and biomarker data.

We also believe that you are a team player that communicate and collaborate in a natural way. Ability to think and act creatively and independently and outstanding record keeping skills are essential - and with your attention to details you will manage the role with success.

Desirable in the role:

* Experience with advanced data analysis tools for analyzing and visualizing pharmacokinetic and biomarker data.
* Operational experience with HPLC-MS/MS for measurement of proteins and nucleotides.
* A proven track record of publication in gene editing, nucleotide and / or large molecule bioanalysis field. Innovative and influential leader, capable of developing strategic approaches to analytical challenges.

Why AstraZeneca?
Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area. Here all doors are open, and every voice is heard. From working side-by-side with academia to innovating with biotech - we are forever expanding our horizons.

So, what's next? If this sounds like the job and place for you - welcome to apply today! We look forward to your application, but no later than 14th August, 2022.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Senior Scientist / Associate Principal Scientist

Kemist
Läs mer Jul 4
AstraZeneca R&D, Gothenburg, Sweden seek to recruit a Senior Scientist or Associate Principal Scientist responsible for Peptide and Conjugation Chemistry within the Medicinal Chemistry department of the therapeutic area Respiratory and Immunology (R&I).

AstraZeneca is one of the world's most exciting biopharmaceutical companies. From scientists to sales, lab techs to legal, we're on a mission to turn science into life-changing medicines that improve patients' lives and benefit society. AstraZeneca is committed to the development of the next generation innovative medicines.


The Department of Medicinal Chemistry in the therapeutic area of Respiratory & Immunology is focused on the delivery of Small Molecule (SM) and New Modalities (NM) clinical candidates. In this context, we are focused on increasing our capabilities around novel peptide and oligonucleotide-based molecules / conjugates for the treatment of respiratory and immunological diseases.


What you'll do
You will be part of a team of scientists dedicated to discovering drugs based on peptide and oligonucleotide chemistry. For this permanent position, you should have a strong background in the design, synthesis, bioconjugation, purification and characterization of novel peptide-based molecules. Your level of professional experience will be relevant for your initial career level (Senior Scientist/Associate Principal Scientist).

Major Duties and Responsibilities:

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Peptide design, synthesis and optimization
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Design and execution of various (bio)conjugation techniques to prepare novel peptide-oligonucleotide conjugates
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Contribution to identify novel delivery technology applicable to peptide and/or oligonucleotide therapeutics
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Effective collaboration with project team members and colleagues in other departments
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Driving internal / external scientific visibility through publications and scientific presentations


Essential for the role

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PhD in Bio-/Organic Chemistry
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Expertise in peptide and/or conjugation chemistry
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Knowledge of recent developments in peptide and (bio-)conjugation chemistry
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Strong scientific curiosity in novel technology and methods
*

Excellent communication and collaboration skills


Desirable for the role

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Knowledge of tissue specific delivery of peptides and/or oligonucleotides is a bonus
*

Experience in pharmaceutical drug discovery of peptide drug candidates is a plus


Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.
With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.


What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! For more information about the position please contact Wu Su, Team Leader, New Modalities Medicinal Chemistry, by email: Wu.Su@astrazeneca.com or via LinkedIn. We welcome your application until August 14, 2022.
NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Ansök nu

Postdoc Fellow - Development of DNA repair inhibitors

Molekylärbiolog
Läs mer Jul 4
Imagine… one day we live in a world, where a diagnosis of a severe genetic disease does not sound terrifying, because almost all genetic diseases have effective medicines to cure them. Here at AstraZeneca, we are developing state-of-the-art tools and models to advance gene and cell therapy approaches. Do you want to be part of this effort?

We're currently looking for a motivated scientist to join our innovative PostDoc Programme. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, where you will be in a global pharmaceutical environment, contributing to live projects right from the beginning.

About the Postdoc Programme:
You'll take part in a training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in groundbreaking laboratories. It's a newly expanding programme spanning a range of therapeutic areas across a wide range of fields.

What's more, you'll have the support of leading academic advisors, who'll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn't been explored to its full potential, making this a chance to create a real difference to the future of medical science.

About the PostDoc role:
As a postdoctoral scientist in the Genome engineering department, you will join an innovative group of robust individuals who are dedicated to science. We focus on pre-clinical research - understanding fundamental biological processes to eventually craft novel therapeutical approaches and strategies of critical value in various disease areas.

You will own an independent project focused on testing and developing novel DNA repair inhibitors to promote genome engineering of Hematopoietic Stem cells. The project will take advantage of modern equipment and proprietary technologies. You will be encouraged to collaborate with top academic laboratories. We will make sure that you have all the resources required to optimally finalized your project and publish your results. Our work led by former postdoctoral scientists was published in leading journals and is highly cited.

Essential in the role:

* PhD degree in molecular/cell biology/genetics.
* Broad multidisciplinary experience and meticulous scientific knowledge (including strong molecular biology skills and advanced understanding of genetic engineering and hands on working on CRISPR-Cas9).
* Strong understanding of Double Strand Break repair pathways and drug modulation of DSB repair.
* Outstanding work ethic (patience, discipline, the desire to work hard, perseverance and the ability to develop and follow a plan).
* A history of previous competitive success.


We also believe that our successful candidate is a creative, innovative, pro-active, forward-thinking, focused, goal-oriented person. As well as a team player who demonstrates a passion for science with an adventurous, growth mentality.

Desirable in the role:

* Proven experience in HSC gene manipulation.
* Expertise with NGS analysis and phenotyping tools (i.e. FACS) to validate genetic perturbations.

Why AstraZeneca?
AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

So, what's next? If you're curious to know more then please reach out to Marcello Maresca marcello.maresca@astrazeneca.com.

We welcome your application no later than 31 August, 2022.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Postdoc Fellow - Development of advanced genome editing methods

Molekylärbiolog
Läs mer Jul 4
Gene Editing by CRISPR-Cas9 has revolutionized biology research and genetic disease treatment. At AstraZeneca and Promega, we are developing state-of-the-art genome editing tools applied to drug discovery. We are now joining forces to further develop our recent described PEn/PRINS technology and apply the learning from this collaboration to model development and disease treatment. Do you want to be part of this unique effort?

We are currently looking for enthusiastic and self-driven scientist to participate in a joint venture between AstraZeneca and Promega as a Postdoc Fellow. This is a 3-year program where you will spend the majority of the time at the AstraZeneca R&D site in Gothenburg, Sweden, and the additional time at the Promega headquarters in Madison (WI), USA.

This is an exciting opportunity to fully experience a global research environment. You will contribute to active projects under the mentorship of leading genome experts.

What you will do:
As a Postdoc Fellow in the AstraZeneca/Promega joint venture, you will be part of a group of passionate researchers who are dedicated to innovation and the advancement of science. Our focus lies primarily in the creation and application of enabling technologies that advance our understanding of fundamental biological processes and aid in the development of novel therapeutical approaches.

You will lead an independent project in a supportive and team-oriented environment, and you will be able to take advantage of facilities equipped with state of the art instrumentation.

Essential in the role:

* PhD degree in molecular/cell biology/genetics.
* Broad multidisciplinary experience and meticulous scientific knowledge (including strong cell and molecular biology skills with an advanced understanding of genetic engineering and CRISPR-Cas9).
* Outstanding work ethic (patience, discipline, the desire to work hard, perseverance and the ability to develop and follow a plan).

To be successful in the role you are a true team player who demonstrates a passion for science with an urge for personal and professional growth, as well as have an adventurous attitude. We also believe that you're a creative, innovative and forward-thinking individual with a focused and goal-oriented mindset.
Desirable in the role:

* Understanding of directed evolution and/or targeted mutagenesis systems
* Expertise with NGS analysis, hands on experience with ddPCR and FACS

Why AstraZeneca in Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centres. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

So, what's next? If this sounds the next challenge for you - apply today!

We look forward to finding out more about you. Welcome to send in your application as soon as possible but no later than 31st August, 2022.

For additional questions, please reach out to Marcello Maresca at marcello.maresca@astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Senior Scientist Chemistry, Compound Management

Kemist
Läs mer Jul 4
Are you a passionate and experienced scientist, eager to join a company in the forefront of sample management technologies? Would you like to contribute to the continuous improvement of life changing projects? Perfect, we have a new challenge for you!

We are looking for a motivated and engaged team member to work as a Senior Scientist in our Compound Management team at our vibrant R&D site at AstraZeneca in Gothenburg, Sweden.

As a Senior Scientist in the Compound Management department you will be responsible for the storage and timely supply of chemical compounds to AstraZeneca's drug discovery projects. Highly automated liquid handling systems will be employed to supply molecules to AstraZeneca scientists and partner organisations. You will be a part of the Discovery Sciences organisation, operating within a first-class scientific environment to support drug discovery across each of AstraZeneca's Therapeutic Areas.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
In this position, you will get the opportunity to work in a dynamic and enthusiastic environment, whilst delivering critical support to drug discovery projects. You are focused on supporting projects by providing compounds in the requested format - assay ready plates, serially diluted mother plates, formulations and solids. You will be involved in all phases of the projects and support a broad range of chemical modalities. Bringing in new capabilities and build new processes are also core activities, performed in collaboration with cross functional drug discovery projects.

You are expected to act upon day-to-day issues that occur whilst processing samples and ensure business continuity and you will run Compound Management development projects to ensure continuous improvement within the local team and the global department. Furthermore, you will work with the following typical tasks:

* Designing, performing and interpreting experiments independently to investigate process improvements and evaluate new technologies.
* Rapidly addressing customer queries with regards to Compound Management orders, software, processes and capabilities.
* Achieving personal scientific visibility through project contributions, internal presentations and publications.

We work collaboratively within our Compound Management team, to provide support within agreed service levels and with a strong quality and customer focus. We strive hard to understand what fits customer needs and how to add value through our experience and capabilities. To maintain this position, we actively seek ways to improve our process and exploit new technologies.

Essential in the role:
Compound Management is a highly collaborative group, working to tight delivery schedules - so the ability to be comfortable working at a fast, goal-oriented pace, with a team focused attitude is essential to be successful in the role. We also believe you have:

* A BSc/MSc in a scientific discipline (life sciences, biotechnology/Chemistry), with some relevant experience.
* Expertise with analytical balances and automated liquid handlers.
* Excellent problem-solving skills and ability to identify and implement improvement activities (experience in workflow automation and /Java coding is beneficial).
* A track record in the performance of a range of practical skills, including non-routine complex tasks, to a high level.

We also believe that our new colleague share our passion for science, technology and innovation. Is a strong team player with a high work ethic that enjoys working in a collaborative setting. You have good social and communication skills with a proactive delivery- and costumer focused approach. Previous experience of working in a compound management role and operating integrated automation equipment and scheduling software is highly beneficial.

Why AstraZeneca?
Here we are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

So, what's next? If you're passionate about the possibilities of science to make a difference, welcome to join us!

We look forward to get to know you and invite you to submit your application as soon as possible, but no later than the 12th of August, 2022.

For more information about the position please contact Karin Kaspersson, Director - Compound Synthesis and Management, at Karin.Kaspersson@astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Senior Director Level Opportunities within Precision Medicine!

Biokemist
Läs mer Jul 1
Are you excited about Precision Medicine? Would you like have an impact on patients' lives and contribute to eliminate cancer as a cause of death? If so then join us!

We're investing like never before in our people, in growth, and in new diagnostic techniques and technologies. There are opportunities at every turn, with a variety and breadth that is uncommon to find and an industry-leading pipeline in oncology. Scientists at AstraZeneca are working every day to turn science fiction into science fact. Our ambition - to develop innovative, targeted medicines for every patient that needs them - and to match those treatments to patients most likely to benefit from them - is now a reality. This approach, known as Precision Medicine, is based on those individual characteristics that make some patients respond to treatment better than others.

The AstraZeneca Companion Diagnostics Unit within the Precision Medicine and Biosamples function drives scientific leadership through the delivery of innovative companion diagnostics enabling our oncology ambition to transform the lives of patients living with cancer, and ultimately eliminate cancer as a cause of death.

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Leading the development of diagnostics across AstraZeneca's early and late stage oncology portfolios through close collaborations with our external diagnostic partners.
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Leading the development and implementation of patient selection strategies to deliver companion diagnostics programs in support of our business priorities.
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Leading companion diagnostic regulatory interactions to secure companion diagnostic approvals in major markets
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Collaborate across AstraZeneca with colleagues in multiple Clinical functions plus commercial to help drive market uptake.
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Developing strategies for early cancer detection, near patient testing and implementing testing options for minimal residual disease and early treatment interventions.
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Utilising artificial intelligence diagnostic solutions and seeing software as a medical device.
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Developing specific disease area strategies (e.g. lung cancer, breast cancer or hematological malignancies) and new diagnostic modalities.
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Collaborating closely with fellow pharma companies on joint assets.

Join this fantastic, collaborative team and be part of our success; we have already delivered over 50 innovative/impactful companion/complementary oncology diagnostic approvals across the major markets of the US, EU, Japan and China since 2014 and we need you to help us take the next steps in patient-centric diagnostic development.

What you'll do
As a Senior Director you'll be a member of the Oncology Companion Diagnostic Unit (CDU). Working collaboratively your objective will be to ensure that innovative diagnostic tests or equivalent segmentation tools are delivered to drug products within your therapeutic area of expertise.

You will achieve this by leading a Global Product Diagnostic sub team made up of functional experts and be empowered to deliver all scientific, technical, clinical, financial, regulatory, intellectual property, commercial and partnering aspects needed to implement the diagnostic strategy. You will be accountable for ensuring that the roles and responsibilities of the team are delivered demonstrating behaviours and values aligned to AstraZeneca Code of Conduct and supporting policies, standards and procedures; including accountability for compliant management of Budget, Safety, Health and Environment.

As a key member of the CDU, one that is aligned to a relevant therapeutic area; you will also be expected to support other therapeutic areas as required. You will be accountable for delivery to several Global Product teams and to act as the single point of contact for all Precision Medicine activities to those product team(s). Being accountable to the Leaders of the relevant product teams you will ensure that the associated diagnostic development reflects world-class practice in the field and contributes to an increased probability of successful drug launch, reimbursement and return on investment.

Your role will also involve contributing to the personal development of project team members. Providing expert advice on strategic and innovative Precision Medicine approaches and companion diagnostic developments to development teams, you'll be instrumental in ensuring that we adopt world-class practice in the field.

Essential

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PhD or equivalent experience in a relevant subject
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Experience in diagnostic tests or segmentation tools in clinical development, within a diagnostic or pharmaceutical setting
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Significant experience of Precision Medicine approaches and diagnostic development within the relevant therapeutic area
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Evidence of excellent skills in communication, stakeholder influencing, programme management, and regulatory interactions
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Effective leadership, performance management and talent management
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Comprehensive understanding of the functions involved in companion diagnostic development and how they contribute to achieving the objectives of the business.

Desirable

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Significant previous experience in similar role in different companies
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Delivery of diagnostics, regulatory interactions and commercialisation
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High quality scientific expertise in the Precision Medicine field and relevant therapeutic area as evidenced by publications and external reputation

If this sounds like the type of organisation where you would like to grow your career and make a real difference to patients then we would like to hear from you.

Ansök nu

Associate Director, Precision Medicine

Forskare, farmakologi
Läs mer Jul 1
Are you excited about Precision Medicine? Would you like have an impact on patients' lives and contribute to eliminate cancer as a cause of death? If so then join us!

We're investing like never before in our people, in growth, and in new diagnostic techniques and technologies. There are opportunities at every turn, with a variety and breadth that is uncommon to find and an industry-leading pipeline in oncology. Scientists at AstraZeneca are working every day to turn science fiction into science fact. Our ambition - to develop innovative, targeted medicines for every patient that needs them - and to match those treatments to patients most likely to benefit from them - is now a reality. This approach, known as Precision Medicine, is based on those individual characteristics that make some patients respond to treatment better than others. We use this knowledge to develop diagnostic tests that doctors can use to help prescribe the best treatment for each patient. Indeed, it's now become common practice for patients with cancer to be offered such diagnostic tests before their treatment plan is agreed.

The AstraZeneca Companion Diagnostics Unit within the Precision Medicine and Biosamples function drives scientific leadership through the delivery of innovative companion diagnostics enabling our oncology ambition to transform the lives of patients living with cancer, and ultimately eliminate cancer as a cause of death.

*

Leading the development of diagnostics across AstraZeneca's early and late stage oncology portfolios through close collaborations with our external diagnostic partners.
*

Leading the development and implementation of patient selection strategies to deliver companion diagnostics programs in support of our business priorities.
*

Leading companion diagnostic regulatory interactions to secure companion diagnostic approvals in major markets
*

Collaborate across AstraZeneca with colleagues in multiple Clinical functions plus commercial to help drive market uptake.
*

Developing strategies for early cancer detection, near patient testing and implementing testing options for minimal residual disease and early treatment interventions.
*

Utilising artificial intelligence diagnostic solutions and seeing software as a medical device.
*

Developing specific disease area strategies (e.g. lung cancer, breast cancer or hematological malignancies) and new diagnostic modalities.
*

Collaborating closely with fellow pharma companies on joint assets.

Join this fantastic, collaborative team and be part of our success; we have already delivered over 50 innovative/impactful companion/complementary oncology diagnostic approvals across the major markets of the US, EU, Japan and China since 2014 and we need you to help us take the next steps in patient-centric diagnostic development.

What you'll do
As an Associate Director you'll be a member of the Oncology Companion Diagnostic Unit (CDU). Your objective will be to ensure that innovative companion diagnostic tests are delivered to our oncology drug projects. This will entail developing and implementing the diagnostic strategy agreed by the respective development teams, and planning and leading Precision Medicine activities from a technical, financial, risk, regulatory, IP and partnering perspective. You will work collaboratively with colleagues at all levels in the Precision Medicine

function to deliver this expertise to drug project teams. Your role will also involve contributing to the personal development of project team members. Providing expert advice on strategic and innovative Precision Medicine approaches and companion diagnostic developments to development teams, you'll be instrumental in ensuring that we adopt world-class practice in the field.

Essential for the role:

*

PhD or equivalent experience in a relevant subject.

*

Experience in companion diagnostic tests or segmentation tools in clinical development OR experience of Precision Medicine approaches and diagnostic development.
*

Effective communication, stakeholder, influencing skills and programme management.
*

Understanding of the functions involved in companion diagnostic development and how they contribute.

Desirable

*

Previous experience in similar role in different companies
*

Delivery of clinical testing, diagnostic, regulatory preparation.
*

Scientific expertise in the Precision Medicine field or relevant therapeutic area as evidenced by publications

Locations: Sweden - Gothenburg; Poland - Warsaw

If this sounds like the type of organisation where you would like to grow your career and make a real difference to patients then we would like to hear from you; apply today!

Ansök nu

Roles within Regulatory Affairs

Biolog
Läs mer Jul 1
Do you have in depth knowledge within Regulatory Affairs and want to develop your skills within project management?

At AstraZeneca, we offer you a unique experience to work in cross functional teams with all phases of drug development, from clinical trials to marketing authorization applications worldwide. You will lead the end-to-end planning, coordination and execution of our submissions and contribute to regulatory submission strategy. Does this match your skills and ambitions for the future? Then join us to develop future treatments of Cardiovascular, Renal and Metabolic (CVRM) diseases!

AstraZeneca's pipeline of innovative medicines is consistently growing within CVRM. Within CVRM Regulatory Affairs we take innovative regulatory approaches to bring these CVRM life-changing treatments to those who need it - working across our early and late-stage development pipeline and the business as efficiently and effectively as possible. As an industry leading CVRM Regulatory function, we're focused and committed to the development of our products as well as to our people - providing an open and supportive space to explore, learn and develop across all regulatory roles and levels.

At AstraZeneca, we are more than 65.000 people in over 100 countries. Our aim is simply to positively impact patients' lives together, as our pipeline of innovative medicines consistently grows. As an industry leading Regulatory function, we're focused and committed to the development of our products as well as to our people. We provide an open and supportive space to explore, learn and develop across all regulatory roles and levels, with the aspiration to make AstraZeneca the place to build your career in Regulatory. Moreover, by introducing a Regulatory academy and laying out a development path, we want to accelerate your professional and personal growth.



The role

We are now seeking new members to join our Regulatory Affairs Management team within the CVRM therapeutic areas, in the roles as Regulatory Affairs Managers (RAM) / Associate Regulatory Affairs Directors (ARAD). These roles can be based in Gothenburg or in Södertälje, Sweden. With employees from more than 50 countries, our sites are a truly inspiring place to work.



What you'll do

Working in the roles as Regulatory Affairs Managers (RAM) / Associate Regulatory Affairs Directors (ARAD), you will have a unique opportunity to work in cross functional teams, with all phases of drug development across geographic regions. With your knowledge, you will contribute to regulatory submission strategy, identify submission risks and opportunities, while leading simple through more complex regulatory applications and managing procedures through approval.



Your main accountabilities/responsibilities:

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Lead and/or contribute to the planning, preparation, and delivery of submissions of varying complexity throughout the product's life cycle from either a global and/or regional perspective.
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Provide regulatory input/ expertise on procedural and documentation requirements as defined by Health Authorities for assigned deliverable(s) including submission delivery strategy of all dossiers and all application types per market and/or region and review of documents, e.g., response documents, study protocols, periodic safety reports
*

Lead multi-disciplinary project teams
*

Support operational and compliance activities for assigned regulatory tasks
*

Provide coaching, mentoring and knowledge sharing within the regulatory skill group
*

Contribute to and lead process improvement
*

Identify regulatory risks and propose mitigations to appropriate member of cross functional teams



Do you have the essential qualifications for these roles?

To be successful in these roles, we believe that you have a University degree in science or a related field. A minimum of 2 years regulatory experience within the biopharmaceutical industry or at a health authority is needed to apply for the role as Regulatory Affairs Manager. To be considered for the more senior role as Associated Regulatory Affairs Director, 4 years' experience of Regulatory Affairs for Medicinal Products in EU, US or other regions is needed as well as proven leadership and project management skills. Both roles require drug development knowledge.

We believe that you possess good project management skills as well as leaderships skills and that you have excellent written and verbal communication skills. If you have previous experience in leading multi-disciplinary project teams, this will be an advantage.

If you are ready to invest in yourself and your regulatory career, then this is the right challenge for you.



So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!

Welcome with your application (CV and cover letter) no later than 7 august, 2022.

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work. Interviews will be held mid-August.

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Patient Safety Program Manager - Gothenburg/Gaithersburg

IT-strateg
Läs mer Jul 12
R&D-IT - Patient Safety Program Manager - Gothenburg/Gaithersburg



About the R&D IT team

Our R&D IT vision is to deliver the best science IT capabilities in biopharma, which we define as agile, responsive and fit-for-future. Our goal is to engage with our stakeholders as a strategic partner in delivering life-changing medicines to our patients. The desired effect of your role is to take accountability as a leader for delivering a 'Best in Class' IT experience within the early and late science units.

This is what you'll do

As the Patient Safety Program Manager, you will lead business and transformation projects/programs, ensure that they align to the vision and business strategy, and that true business value is delivered to the customer as a result. Having a strong partnership with the business customer driving the demand for the solution is critical to achieve success. As such, you will not only meet demand, but also challenge and renegotiate demand as needed based on strategic technical drivers and corporate ambitions. The Program Manager is genuinely dedicated to deliver, with a strong customer experience focus. You will use process as guidance for achieving delivery, and constantly look for innovative means to deliver quicker and more seamlessly within the process guideposts. You will be accountable for ensuring solutions solve key business needs in a coordinated and simple manner, exploiting existing assets where feasible, and minimizing the long term total cost of ownership. The role will ensure that delivery occurs by prioritizing and keeping speediness of response, and can be completed within the approved program budget and schedule commitments, whilst continuously assessing risk and balancing the need for flexibility and agility with conformance to standard methods and tools. In this role your focus areas will include stakeholder management across Business, IT, and vendor partners, risk management and delivery of business benefit. This role will also collaborate with others in Program and Project Management, and drive development of the project / program management capability across IT in a tangible and measurable way.

What you'll need

You are experienced and skilled in delivering, running and controlling large projects /programs, within a multinational and matrixed organization. You are an excellent communicator with good facilitation skills, and enjoy collaborating with others to achieve goals. You are comfortable working across cultural boundaries and interacting with Senior Leadership Teams, as well as negotiating across complex groups.

You will also need:

* Technical, Science or Business degree, alternatively equivalent years of experience
* Project Management experience, ideally in a Pharmaceutical IT environment
* Experience of working with onshore and offshore suppliers, and also internal delivery teams
* Understanding of quality and compliance
* Experience shaping innovative solutions
* The ability to travel both domestically and internationally
* High levels of drive, energy, resilience
* Confident in taking ownership and enterprise leadership to deliver high quality solutions that resolve business problems



Why join us

Join us at a crucial stage of our journey in becoming a digital and data-led enterprise. Make the impossible possible by building partnerships and ecosystems, creating new ways of working and driving scale and speed to deliver exponential growth. Focused and committed, and backed with the investment to succeed, we're driving cross-company change to disrupt the entire industry.



About AstraZeneca

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.



SO, WHAT NEXT?

Are you up for an exciting challenge and ready to make a difference? If so, hit Apply today - we can't wait to hear from you!



Open Date: 12/ 07/ 2022
Close Date: 26 / 07/ 2022

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Director, Precision Medicine

Biokemist
Läs mer Jul 1
Are you excited about Precision Medicine? Would you like have an impact on patients' lives and contribute to eliminate cancer as a cause of death? If so then join us!

We're investing like never before in our people, in growth, and in new diagnostic techniques and technologies. There are opportunities at every turn, with a variety and breadth that is uncommon to find and an industry-leading pipeline in oncology. Scientists at AstraZeneca are working every day to turn science fiction into science fact. Our ambition - to develop innovative, targeted medicines for every patient that needs them - and to match those treatments to patients most likely to benefit from them - is now a reality. This approach, known as Precision Medicine, is based on those individual characteristics that make some patients respond to treatment better than others. We use this knowledge to develop diagnostic tests that doctors can use to help prescribe the best treatment for each patient. Indeed, it's now become common practice for patients with cancer to be offered such diagnostic tests before their treatment plan is agreed.

The AstraZeneca Companion Diagnostics Unit within the Precision Medicine and Biosamples function drives scientific leadership through the delivery of innovative companion diagnostics enabling our oncology ambition to transform the lives of patients living with cancer, and ultimately eliminate cancer as a cause of death.

We do this by:

*

Leading the development of diagnostics across AstraZeneca's early and late stage oncology portfolios through close collaborations with our external diagnostic partners.
*

Leading the development and implementation of patient selection strategies to deliver companion diagnostics programs in support of our business priorities.
*

Leading companion diagnostic regulatory interactions to secure companion diagnostic approvals in major markets
*

Collaborate across AstraZeneca with colleagues in multiple Clinical functions plus commercial to help drive market uptake.
*

Developing strategies for early cancer detection, near patient testing and implementing testing options for minimal residual disease and early treatment interventions.
*

Utilising artificial intelligence diagnostic solutions and seeing software as a medical device.
*

Developing specific disease area strategies (e.g. lung cancer, breast cancer or hematological malignancies) and new diagnostic modalities.
*

Collaborating closely with fellow pharma companies on joint assets.

Join this fantastic, collaborative team and be part of our success; we have already delivered over 50 innovative/impactful companion/complementary oncology diagnostic approvals across the major markets of the US, EU, Japan and China since 2014 and we need you to help us take the next steps in patient-centric diagnostic development.

If this sounds like the type of organisation where you would like to grow your career and make a real difference to patients then we would like to hear from you.

We are currently looking for a Director.

What you will be doing
As a Director, you'll be a member of the Oncology Companion Diagnostic Unit (CDU). Your objective will be to ensure that innovative companion diagnostic tests or equivalent segmentation tools are delivered to our oncology drug projects. Drawing on world-class expertise and personal experience in companion diagnostic development you will ensure the adoption of Precision Medicine approaches within the AstraZeneca business. You will also provide leadership and support to a pool of fellow diagnostic experts to ensure delivery of a diagnostic strategy.

This will entail developing and implementing the diagnostic strategy agreed by the respective development teams, and planning and leading Precision Medicine activities from a technical, financial, risk, regulatory, IP and partnering perspective. You will work collaboratively with colleagues at all levels in the Precision Medicine function to deliver this expertise to drug project teams.

Your role will also involve contributing to the personal development of project team members. Providing expert advice on strategic and innovative Precision Medicine approaches and companion diagnostic developments to development teams, you'll be instrumental in ensuring that we adopt world-class practice in the field.

Essential:

*

PhD or equivalent experience in a relevant subject.
*

Experience of companion diagnostic tests or patient biomarker/segmentation tools in clinical development.
*

Experience of Precision Medicine approaches and diagnostic development within the relevant therapeutic area.
*

Effective communication, stakeholder, influencing skills and programme management.

*

Significant understanding of the functions involved in companion diagnostic development and how they contribute to achieving successful diagnostic submissions and approvals

Desirable :

*

Significant previous experience in a similar role in different companies.
*

Delivery of companion diagnostics, regulatory interactions and commercialisation.
*

High quality scientific expertise in the field of Precision Medicine or relevant therapeutic area as evidenced by publications.

If this sounds like the type of organisation where you would like to grow your career and make a real difference to patients then we would like to hear from you; apply today!

Ansök nu

Senior Research Scientist - DNA encoded library synthesis

Organisk kemist
Läs mer Jun 30
Do you have hands-on experience and great knowledge with the synthesis of DNA encoded libraries? Are you interested in establishing and developing our new DEL synthesis lab at a company where we are committed to lifelong learning, growth and development? If yes, this might be the role for you!

We are looking for a specialized Synthetic Chemist that will play an important part in our iLAB team, focusing on the synthesis of novel DNA encoded libraries (DEL). You will have the opportunity to drive and influence the DEL synthesis capabilities in our newly created lab at AstraZeneca in Gothenburg, Sweden and contribute to the production of a proprietary compound collection based on DEL.

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. With our ground-breaking pipeline comes a bright future - a secure job, exciting opportunities and varied work. You will be valued. Not only for your unique contribution, skills and background, but because we recognize people are our greatest asset. Here we are dedicated to being a Great Place to Work.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
This is an exciting role where you will contribute from an early stage to the development of the newly created DEL synthesis lab capabilities at AstraZeneca Gothenburg. You will design and synthesize DNA encoded libraries - and use and develop currently available chemistry automation for DEL synthesis. You will also contribute to the continuous improvement of the DEL synthesis platform by developing and applying new, groundbreaking synthetic approaches for on-DNA chemistry and by evaluating new technologies.

In your daily work you will troubleshoot laboratory-based problems and make a significant contribution to the delivery of the team. As a DEL Chemist, you will maintain access to the best internal and external science and enhance business reputation internally and externally through peer-reviewed publications and oral/poster presentations.

Essential in the role:
You're a chemist with a track record of applying innovative chemistry solutions, with resulting impact in project delivery. You also have:

* Ph.D. in a relevant chemistry field, or a Master degree in chemistry with minimum 5 years' experience in synthetic organic chemistry.
* Hands-on experience with on-DNA synthesis and/or synthesis of DNA encoded libraries.
* Expertise in theoretical and practical organic synthesis, retrosynthesis, compound route design, purification and analytical sciences.
* Expertise in parallel chemistry.
* Knowledge of basic molecular biology techniques e.g gel electrophoresis, DNA ligation, PCR.
* Advanced knowledge of modern chemical literature, chemical technologies and applying new ideas to project delivery.
* A track record of driving innovation in chemistry related sciences.

The successful candidate should be motivated to work effectively in hardworking teams and demonstrate ability to work across scientific fields to get results. We also believe that our candidate have effective levels of communication, a scientific drive and a high interest in working with organic chemistry and molecular biology techniques.

Desirable in the role:

* Experience in the development of on-DNA chemistry.
* Experience in methods development.
* Experience with chemistry automation.
* Knowledge in designing high-throughput chemistry and/or library synthesis experiments using bespoke design software.
* Knowledge of medicinal chemistry.

We also believe that the successful candidate have a detailed understanding of the chemical sciences and how they contribute and influence drug discovery together with knowledge of the drug discovery process.

Why AstraZeneca Gothenburg?
With more than 2,400 employees from over 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So, what's next? If this sounds like your next challenge - apply today!

Welcome with your application, but send it to us no later than 15th August, 2022.

For more information about the position please contact Nidhal Selmi, Director of Chemistry - DNA-Encoded & Compound Collection Libraries - iLAB, at nidhal.selmi(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About iLAB - Innovation Lab: https://www.astrazeneca.com/r-d/our-technologies/ilab.html

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

Ansök nu

Associate Principal Scientist / Principal Scientist - DMPK

Kemist
Läs mer Jun 16
Are you an experienced DMPK scientist with expertise in drug discovery? Would you like to apply your expertise in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for! Join us as a Preclinical DMPK Project Lead!


We are now looking for an experienced and motivated individual to join our team as an Associate Principal Scientist or Principal Scientist, depending on your level of professional experience. You will be part of the DMPK Department within Early Respiratory & Immunology (R&I) and this position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden, one of AstraZeneca's three strategic science centers.



At AstraZeneca Respiratory & Immunology (R&I), we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.



What you'll do
In the role you would work collaboratively with discovery project representatives from other fields including medicinal chemistry, biology, safety and pharmaceutical sciences. You will influence drug design and optimization of ADMET (absorption, distribution, metabolism, excretion, toxicity) properties. Hence, it is your responsibility to ensure delivery of all DMPK related activities, including in vitro ADME, biotransformation, bioanalysis, preclinical PK and PD. Using your knowledge and experience to translate and incorporate all of this information into a framework underpinning human dose prediction on discovery projects from target selection to candidate drug selection.



We believe that you have a solid understanding of DMPK and chemistry and that you will be able to provide expert advice and interpretation of complex drug discovery data.

Main Duties and Responsibilities
* Responsible for leading all DMPK related activities, including coordinating and engaging with internal and external DMPK colleagues and collaborators, on project related activities
* Deliver DMPK input and data to projects within agreed timelines and to the right quality to ensure that DMPK challenges are thoroughly assessed and resolved
* Contribute to the design of preclinical in vivo PD studies to answer crucial project questions
* Accountable, together with other functions such as Medicinal Chemistry, Bioscience and Safety, for compound design and effective cross-discipline optimization
* Apply an understanding of DMPK and PKPD to support/influence project progression and strategy as well as providing the framework for human dose predictions
* Prepare clear presentations related to the above for internal governance interactions



Essential for the role
* PhD in chemistry, biopharmaceutics, pharmacokinetics or equivalent experience in a relevant field
* Formal training or proven experience of working with pharmacokinetics and drug metabolism and a good understanding of pharmacodynamics
* Understanding of physicochemical properties and their influence on ADME properties and the ability to apply this understanding to design of new molecules
* Have (at least) basic PK modelling skills, experience of human PK and dose prediction, as well as an understanding of disease biology and PKPD
* Extensive experience (5+ years) of working in preclinical DMPK
* Experience from drug discovery, cross-functional working and molecule/project progression
* Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery
* Strong communication skills



What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until August 12, 2022.
NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.



Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

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IT Quality Manager

Helpdesktekniker/Supporttekniker
Läs mer Jun 30
Experienced in IT Regulatory Support with a progressive approach? Would you like to be part of a globally located team with various backgrounds and experiences? Then this might be your next opportunity!

In this role your mission will be to contribute to protecting AstraZeneca's license to operate through industry leading delivery and maintenance of excellent compliant innovation, projects and services. This function will also coach and educate the business and broader workforce on optimally integrating Compliance Requirements into all IT Lifecycle activities. You will work on a truly global scale, with collaborators across Asia, EU, North America and South America - together supporting a broad stakeholder community. The role works closely with representatives across business and IT functions, acting upon risks and issues to pro-actively strive to increase the levels of quality and compliance across IT.

You will use your pharmaceutical regulatory compliance experience and intelligence to support and deliver an integrated IT QM strategy. The role is responsible for understanding and applying regulatory compliance policies and standards. Using a risk-based approach, proactively engage with and drive IT inspection readiness activities for sites within your scope as well as contribute to the creation of a global plan. In addition, the role will support the delivery of compliant projects and programmes.

With your initiative and dedication to identify and deliver continuous improvement opportunities, you will be expected to:

* Utilise the quality management planning approach and processes ensuring that organisational, inspection and supplier compliance risks are identified, assessed, and mitigated in support of the license to operate
* Influence compliance activities over project delivery methodologies (e.g. Agile, Waterfall), processes and underpinning tools to build value and simplification
* Actively contribute towards the overall planning, governance and Tier reporting of key metrics and measures
* Utilise Quality insights to improve performance, productivity and alignment to our processes, and to drive value for peers and stakeholders
* Support the development and delivery of integrated strategies for Lean, Tools, Automation, Digital and AI

Requirements
This role needs you who is a progressive IT Quality Management professional that understands the evolving external regulatory landscape and is an expert at integrating business appropriate risk management techniques. Experienced in contributing to implementation of a Quality and/or Compliance strategy with the ability to prioritise and understand the impact of the decisions made You are comfortable with operating across business functions and geographies in large, intricate and evolving IT environments and possess strong change leadership and team working skills. As the role includes collaboration with a non-technical business audience it is also important that you are capable of discussing technical IT-terms in an inclusive manner. You are energetic and high-reaching, and are able to hold self and others accountable for actions.

We also see that you have:

* BA, BSc in Computer or Life Sciences or equivalent, with solid experience in the pharmaceutical industry regulatory requirements
* Knowledge and experience of working with/providing IT regulatory support to Site Quality groups
* Expertise in working with and providing regulatory support, including computerised system validation/assurance activities.
* Knowledge of industry good practice and standards such as ISO 9000, ISO 27002, CMMI, GAMP, GxP, ITIL, S404 Sarbanes-Oxley
* Knowledge of emerging regulatory/digital trends and risks affecting the pharmaceutical industry
* Ability to make pragmatic decisions by analysing complex/time-critical situations, assessing risks and identifying mitigating compliance/quality requirements
* Concern for impact, analytically minded and able to prioritise and plan using initiative
* Fluent in Swedish and English

About AstraZeneca
At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

SO, WHAT NEXT?
Are you up for an exciting challenge and ready for making a difference? If so, hit Apply today - but no later than 28th of July 2022.

Ansök nu

Safety Physician - Patient Safety Vaccines & Immune Therapies

Specialistläkare
Läs mer Jun 29
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Patient Safety at AstraZeneca is now looking for a Safety Physicians to join our Patient Safety Vaccines & Immune Therapies team. The positions will be based in Gothenburg, Sweden. We are offering opportunities at different levels (e.g. Safety Physician, Senior Safety Physician or Principal Safety Physician) depending on your expertise and previous experience.

The current positions are within the therapy areas of Vaccines & Immune Therapies. The core purpose of AstraZeneca Patient Safety is to add value to AstraZeneca products, provide clear science-based guidance for investigators and prescribers to safeguard patients as well as the success of our business. Patient Safety covers the entire clinical life cycle of a drug from first time into man to withdrawal of a product from the market.


What you'll do
You will get the opportunity to engage with key internal and external stakeholders to provide scientific leadership and channeling our scientific capabilities to make a positive impact on changing patients' lives. You will get a broad global exposure to other functions involved in the R&D process within AstraZeneca, as well as an overview of how strategic direction is set within the Clinical function and how decisions are made during drug development. Your work will be integrated with cross-functional teams in Clinical Development using your expertise to put a wide variety of issues into a clinical context to make informed decisions.

You will be responsible for providing medical expertise regarding the safety profile of the product(s) and the disease area while representing the patient and Health Authority perspective. This involves working closely together with global colleagues both from within the Patient Safety Department as well as other groups in AstraZeneca. Your key tasks will include using medical judgment to understand case histories, reviewing safety data in various formats to determine any findings of potential importance, helping identify, communicate and manage safety risks and providing a Patient Safety position in meetings and documents.


Essential for the role
You who will accept the challenge have a Medical Degree, experience from clinical practice and preferably also working experience from drug development in the pharmaceutical industry. PhD degree is meriting. You have a broad understanding about Health Authority regulations and Good Clinical Practice Standards and if you have experience from working with safety evaluation and risk management - that's great! At AstraZeneca you will fit right in if you are fluent in written and spoken English, thrive on team work, networking, communication and the ability to influence both people and science.

This is an exciting opportunity for professional growth in areas of drug development, science, and leadership. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

Why AstraZeneca?
Our purpose is ambitious and so is our approach. Becoming a more agile and innovative company means building a dynamic, inspiring culture where we celebrate forward thinking and act with a sense of urgency. We are ambitious, take informed risks and learn from both success and failure. We are curious, creative and open to new ideas and ways of working. Above all, we are passionate about science and driven to always put patients first. Are you ready to move forward in your career?

So, what's next!
We would like to know more about you. If you are interested, apply now!

Due to summer vacations the screening period will be longer than usual but we will try to get back to you as soon as we can.

Welcome with your application no later than 27 July, 2022.



Location: Gothenburg, Sweden

Find out more:
The Gothenburg site:
https://www.astrazeneca.com/our-science/gothenburg.html
Culture and atmosphere of the site:
https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/
Life in Gothenburg and Sweden:
https://www.movetogothenburg.com/

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Senior Scientist - Formulation Engineer

Forskare, farmakologi
Läs mer Jul 12
Do you have an interest in the area of pharmaceutical technology and want to drive drug development projects forward? Would you like to apply your expertise to make an impact in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

AstraZeneca is a global, innovation-driven BioPharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious disease. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit.

Pharmaceutical Technology and Development (PT&D) apply science and technology that turns concepts into actual medicines which help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines - from supplies for use in toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

We are now looking to hire a Formulation Engineer (Senior Scientist), to strengthen our team in Gothenburg, Sweden. This is an outstanding opportunity for an enthusiastic, innovative and motivated Formulation Engineer who aims to be part of an efficient Oral Product Development (OPD) team!

In OPD, a division of Pharmaceutical Technology & Development , we focus on the design and development of commercial products and processes and contribute to new product introductions and continuous improvement of launched products. Products in scope are e.g. immediate and controlled release solid oral dosage forms of small molecules for diverse therapeutic areas. To meet the future needs of our portfolio the introduction of new technology and science is an important factor, and the use of modelling and simulation tools is a part of our daily work.


What you'll do

We are looking for a lab based senior scientist that can balance formulation development and process engineering with a passion for application of digital tools. In this role you will work closely with a team of colleagues in a multi-skilled environment to design, develop and deliver high quality clinical and commercial formulations and processes. You can expect to contribute to programs of laboratory and pilot scale experiments and technical knowledge transfer to commercial manufacture through a combination of hands-on experimental work and using modelling and simulation approaches.

* Work hands-on to generate data as well as work collaboratively with other experimentalists with different backgrounds to identify/use/drive digital applications to strategically direct experimentation.
* Be part of cross-functional teams delivering drug projects, including contributions to regulatory documentation and submissions, applying your understanding of drug development and relevant requirements from medical authorities.
* Take part in tech transfer of manufacturing methods to other sites (within and/or outside AZ) and give consultation to internal and external parties
* Be a key player to drive and further develop the digital transformation within OPD.
* Establish strong working relationships with the Modelling & Simulation team members and with other colleagues in Product Development to enable an impact-driven application of modelling and simulation tools.
* Manage your own work to achieve drug development and improvement project targets, in a timely fashion and to agreed quality standards, by applying technical knowledge and expertise as well as interpreting results and adapting investigations as appropriate.
* Participate in scientific and/or technology networks to increase base-line knowledge and create awareness of new developments in relevant areas

Essential for the role

* Highly likely to be a PhD or an experienced MSc in chemical engineering, pharmacy or similar discipline
* A rational approach to problem solving, and an ability to make judgements based on sound reasoning.
* Ability to proactively apply modelling and simulation to deliver value in development and manufacturing of pharmaceutical drug products.
* Strong collaborative and communication skills
* Excellent English, both written and spoken.
* Operates confidently and collaboratively within a global organisation, with an integrating mind-set

Desirable for the role

* Experience of pharmaceutical products and process equipment and technology, including product design and methods for experimental characterization and a track record of using multi-variate analysis and chemometrics.
* Having a knowledge of operational requirements including GMP, Process Safety, Data integrity and Change Control.
* Experience of continuous processing in a pharmaceutical environment.
* Experience of applying modelling and simulation tools

Why AstraZeneca?

There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what's next?
We welcome your application, including CV and cover letter, no later than August 14th, 2022.

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Director for Mechanistic Biology and Profiling Team in Sweden

Forskningschef
Läs mer Jul 4
Do you possess leading expertise within pharmacology and have a passion for drug discovery? Are you a dedicated and experienced enzymologist/in vitro pharmacologist? Would you like a role where your expertise, as well as your leadership skills, will be highly appreciated? Welcome to join us at AstraZeneca!

We are currently recruiting a Director in the Mechanistic and Structural Biology (MSB) department in Gothenburg, Sweden to lead a Mechanistic Biology and Profiling (MBP) team. In this role, you will pursue world-class medicines in new ways working with exceptionally skilled people from all over the global AstraZeneca R&D organisation.

MSB is a global multidisciplinary function that includes expertise in pharmacology, biochemistry, enzymology, cell biology, structural biology and a broad range of biophysical methods to support the progression of compounds from hit to candidate.

Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

What you will do:
As Director within MSB you will lead a high-performing team to provide early, impactful mechanistic insight to projects across CVRM, R&I and NS therapeutic areas, through a combination of in vitro enzymology, pharmacology, and quantitative cell biology. You will be accountable for establishing and driving capabilities to support the AZ Oligonucleotide Discovery platform and act as point-of-contact for oligonucleotide based projects' lead generation planning. You and your team will generate pre-clinical pharmacology data to profile proprietary compounds and underpin SAR development as well as investigate compounds' detailed mechanism of action to predict and understand efficacy and novel therapeutic modalities.

You will represent the department across a broad range of drug discovery projects and global initiatives as well as externally. You will drive scientific and technical innovation, including through external collaborations and partnerships. You will participate in setting and maintaining the strategic direction, scientific quality and efficiency of the global MSB department, and contribute to the development and execution of DS and AZ's global research strategies.

Essentials in the role:

* PhD/Post-doc or equivalent in the fields of Pharmacology / Cell Biology / Biochemistry or related disciplines with 8+ years' experience ideally gained in a drug discovery environment.
* Comprehensive understanding of the quantitative biology-based disciplines (enzymology, pharmacology).
* Extensive experience and expertise in screening, assay design and technology, mechanism of action studies, statistical tools and advanced data analysis ideally gained in a drug discovery setting.
* Proven expertise in oligonucleotide research and in vitro pharmacology.
* Experience in managing teams of highly qualified personnel working in related scientific disciplines.
* Proven track record of career progression, and external scientific reputation gained through professional recognition, conference presentations and publications.
* Experience in establishing and leading external collaborations and technology change projects to advance or establish new capabilities.
* Track record of delivering results across a diverse project portfolio by driving strategic, scientific, financial and people performance.

We also see you as a passionate and energetic leader with ability to articulate and communicate a vision, set direction and inspire commitment towards your team to together create drug discovery projects' success.

Desirable in the role:

* Generates exceptional results by influencing, driving performance and collaborating across project and country boundaries.
* Demonstrated ability to initiate and successfully deliver value from external collaborations.
* Knowledge of the competitive landscape in the fields of Oligonucletide Therapeutics, Pharmacology, Cell Biology, Biochemistry and Enzymology and related cutting-edge technologies applied to drug discovery.
* Good working knowledge of all the disciplines and areas of responsibility of MBP Sweden.

Why AstraZeneca?
Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area. Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.

Does this sound like your next challenge and place to work? Apply today!

We look forward to your application, but no later than 25th July, 2022. For more information about the position please contact Maria Flocco - VP Mechanistic & Structural Biology at maria.flocco(at)astrazeneca.com.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

NOTE - Due to our summer vacation period in Sweden during July-August, the screening process may take a bit longer than usual. Thanks for your understanding and we will get back to you as soon as possible when we are back at work.

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Senior Bioinformatician for Therapeutic Gene Editing

Systemutvecklare/Programmerare
Läs mer Jun 23
At AstraZeneca we harness digital, data science & AI to fast-forward our research. Making sure work born in a lab can make a real difference. Working here means thinking big and working together to deliver impact from our contributions that make the impossible a reality.

We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas. Through our integration with Alexion, this now includes expanding the limits of scientific research to better understand rare diseases and to discover new life-changing treatments for them.

Discovery Sciences work across all therapy areas at AstraZeneca to deliver candidate drugs into late-stage clinical development. The Data Sciences and Quantitative Biology team within Discovery Sciences is a multi-disciplinary team of data scientists with the purpose of providing quantitative insights to biology. In partnership with our experimentalist colleagues, we provide computational analysis and solutions to enable and drive our drug discovery efforts forward.

We have an exciting opportunity to join our team as a Senior Bioinformatician for Therapeutic Gene Editing. This position will be based at our vibrant R&D site in Gothenburg, Sweden.

What you'll do
In this role you'll be using bioinformatics and machine learning to identify and deliver gene editing designs e.g. CRISPR guide RNAs. You will be responsible for developing and internalising appropriate algorithms, techniques and datasets to advance our ability to rapidly discover gene editing candidate drugs.

You will also enhance our data analysis capabilities on complex, high-dimensional omics data to identify biologically induced effects of CRISPR based drugs. Further you will be contributing to and leading local and global projects for NGS applied in gene editing projects and ensuring that results are scientifically robust and documented.

Essential for the role
We expect you to demonstrate a passion for driving scientific questions and being capable of receiving and analysing input from multiple fields and deciding on focused course of action. You have a consistent track record of delivering analytical solutions for business or academic needs. You are able to work independently and have a positive, result-oriented and problem-solving attitude. We also believe that you enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.

* PhD, or equivalent, in bioinformatics, mathematics, computer science, statistics, engineering or the life sciences
* Expertise in one or more of the core competency areas: CRISPR, DNA/RNA sequence analysis, next generation sequencing analysis, multivariate and/or high dimensional data analysis (omics), ontologies, data management, machine learning, statistical modelling.
* Experience with relevant software tools such as R and/or Python
* Proficiency in working in a Linux environment, experience with shell scripting and standard command line tools
* Understanding of molecular biology, cell biology, and human physiology
* Familiarity with tools for reproducible research such as git, conda, Snakemake or Nextflow
* Excellent English, spoken and in writing

Desirable for the role
Experience from industry gene editing bioinformatics is a great plus but with strong bioinformatics skills we expect that you will quickly develop specific knowledge about gene editing drug discovery.

Why AstraZeneca Gothenburg?
With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So, what's next!
Does this sound like your next position? Apply now!

We look forward to find out more about you. Send in your application as soon as possible, but no later than August 5th, 2022.

For more information about the position please contact hiring manager Fredrik Karlsson (https://www.linkedin.com/in/fredrik-karlsson-140a7782/).

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

#DS&QuBi;

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Global Clinical Operations Program Director

Biomedicinare
Läs mer Jun 8
Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!


We have an exciting opportunity to join our team as a Global Clinical Operations Program Director within the Clinical Operations function of Late Stage development in Respiratory and Immunology (R&I) Therapeutic Area. This is an office based position that can be situated at our sites in Gothenburg(SE), Gaithersburg/Durham (US), Warsaw (Poland) or Cambridge (UK).


What you'll do
As a Global Clinical Operations Program Director you will work in a global role within the Clinical Operations function of Late Stage R&D (Biopharmaceuticals). The span of responsibilities is broad and may support one or several products depending on their size and complexity. The products supported may include studies in all phases of drug development.


The Global Clinical Operations Program Director is responsible for oversight of a program of global studies, covering all clinical development deliverables (including aspects of quality, budget, time, resource and risk). The role also involves integrating design, feasibility and operational planning to ensure clinical drug development programs are aligned with priorities and strategy. The role will provide input & support to the Senior Global Clinical Operations Program Director in preparation for new business case opportunities for review by governance interactions and may act as the lead for cross-functional teams in delivery of various clinical activities and manage improvement or change projects within clinical operations or spanning multiple business areas.

Typical Accountabilities:
* Lead cross functional teams of experts in the planning and delivery of a defined clinical program of studies and/or clinical activities to scope, quality, budget, time, planning the resource and managing risk.
* Work closely with global study leaders to provide appropriate strategic oversight of a program of studies on behalf of Sr Global Clinical Operations Program Director and Clinical Program Team (CPT)
* Responsible for providing clinical operations expertise into the development of new business case opportunities for review by governance
* Lead cross functional Clinical Submission Teams in planning and execution of clinical contribution to Marketing Applications, maintenance support for regulatory interactions and reports and inspection readiness.
* Lead large or complex deliverables and the process to identify and solve or escalate operational issues. Drive delivery to plan through internal or external partners (alliance partners, Clinical Research Organizations (CROs), vendors and Academic Research Organizations (AROs)).

Essential for the role
* University degree (or equivalent), preferably in medical or biological sciences or discipline associated with clinical research.
* At least 10 years' experience from within the pharmaceutical industry or similar large multinational organization and proven experience of clinical development / drug development process in various phases of development and therapy areas.
* Experience from leading clinical projects and deliverables or similar expertise from other areas of drug development (such as pharmaceutical development) and proven knowledge of project management tools and processes
* Proven leadership promoting motivation and empowerment of others in order to accomplish individual, team and organizational objectives. Ability to mentor, develop and educate staff
* Excellent written and verbal communication skills, negotiation, collaboration and interpersonal skills with ability to work effectively with others at all levels of the organization


Desirable for the role
* Project management certification
* Knowledge of process improvement methodology such as Lean Sigma/Change Management
* Regulatory submission experience
* Proven knowledge of clinical operations
* Experience with development and implementation of digital health initiatives in Clinical Studies


This is an exciting opportunity for professional growth in areas of drug development, science, and leadership. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us!


Why AstraZeneca?
AstraZeneca is a global, innovation-driven BioPharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious disease. But we're more than one of the world's leading pharmaceutical companies.


What's next!
We welcome your application; CV and cover letter, no later than August 14, 2022.


Where can I find out more?
Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en


Opportunity: Global Clinical Operations Program Director

Locations: Gothenburg, (Sweden), Cambridge (UK), Gaithersburg (US), Durham (US), Warsaw (Poland)

Salary: Competitive salary and benefits package on offer

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Clinical Pharmacology Expert in CVRM

Forskare, farmakologi
Läs mer Jun 21
Do you have expertise and experience in clinical pharmacology, PK, PKPD, Model Informed Drug Development (MIDD) and its application in drug development? Would you like to apply your expertise in a company that is following the science and turn ideas into life changing medicines? If yes, we have the position for you at AstraZeneca!

We now have an exciting opportunity for an engaged and diligent individual to join our growing Clinical Pharmacology and Quantitative Pharmacology (CPQP) team at AstraZeneca at our vibrant Gothenburg site in Sweden, as a Senior Scientist, Associate Director or Director depending on your background, experience and skills.

This is a global role that will support large- and small molecule projects across all phases of clinical development within the therapy area of Cardiovascular, Renal and Metabolism.

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. Within the Clinical Pharmacology and Safety Sciences (CPSS) function at AstraZeneca, we have a state-of-the-art Clinical Pharmacology and Quantitative Pharmacology (CPQP) organization with a diverse and uniquely skilled team of clinical pharmacometricians, clinical pharmacology scientists and other experts. You will thrive in an energising environment where challenging work goes hand in hand with development. With opportunities, recognition and bright minds, there's no better place to unlock learning and build a long-term career. Gothenburg is a key research and development location for our Cardiovascular, Renal and Metabolism area.

What you will do

Working closely with clinical pharmacometricians, physicians and other scientists, you will apply your expertise and leadership skills to contribute to the strategy of the clinical development program and the design and interpretation of clinical studies. You will influence key decisions in early and late phases of clinical development.

In collaboration with clinical pharmacometricians, you will represent CPQP in cross-functional project teams, and be responsible for developing the clinical pharmacology strategy. The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. You will take part in finding opportunities to apply model informed drug development to accelerate and advise decision making. Based on your interest, skills and experience, you might also perform some pharmacokinetic and pharmacometrics modelling and simulation acting as a dual Clinical Pharmacometrician/Clinical Pharmacologist. You will communicate your findings within and outside of AstraZeneca and publish in peer reviewed journals.

Minimum requirements for the role

* PhD or equivalent (M.Sc/Pharm.D.) in clinical pharmacology or other relevant area
* Good knowledge of pharmacokinetics, PKPD and Clinical Pharmacology
* Biological understanding of disease and drug action
* Good oral and written communication skills

Desirable in the role

* 3+ years of industry experience or equivalent in pharmacokinetics and clinical pharmacology in drug development
* Track record in creating and delivering on clinical pharmacology strategies of both small and large molecules
* Early and late phase clinical development experience
* Good knowledge and experience in use of PK and PKPD modelling and its clinical application
* Recognized clinical pharmacology expertise as demonstrated by scientific publishing in the field of clinical pharmacology

We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your skills, abilities and contribution. You have a real passion for your subject, along with a collaborative nature and ability to work in multi-disciplinary global teams.

Why AstraZeneca?

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. Collaborate in an inclusive environment, a place full of bold new opportunities. Be empowered to be innovative and creative where difference is valued.


So, what's next! Does this sound like your next challenge? Apply today!
We look forward to find out more about you. Send in your application as soon as possible, we will review applications continuously.

For more information about the position please contact the hiring managers, Angelica Quartino (https://www.linkedin.com/in/angelica-quartino-352a7b2/) or Ann-Charlotte Egnell (https://www.linkedin.com/in/lotta-egnell-9595b0a/)

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg site: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Read more about BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html
Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/

#DataAI

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Statistician to Data Sciences & Quantitative Biology

Matematiker
Läs mer Jun 1
Are you a curious and enthusiastic Statistician or Data Scientist? Would you like to join us on our journey where your contributions will have a profound impact on R&D using the latest statistical and machine learning methods? If yes, we have the position for you!

We see you as our new Statistician in our Data Sciences & Quantitative Biology department based at our vibrant AstraZeneca R&D site in Gothenburg, Sweden. The team you will join is built up of statisticians, bioinformaticians, machine learning specialists and image analysts. In this position you will be a part of our Discovery Sciences function that applies deep technical expertise in specialist technologies to support the delivery of targets and molecules to the early AstraZeneca pipeline.

As a dedicated BioPharmaceuticals R&D organisation, we accelerate promising early-stage assets and lifecycle management programmes. From discovery to late-stage development, we always follow and push the boundaries of science. At AstraZeneca, we're also committed to being a Great Place to Work and there is no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

What you will do
You will get the opportunity to apply your statistical knowledge to collaborate with researchers in a variety of project teams.

We will rely on you to:

* Identify and deliver solutions for addressing key biological questions by using statistics
* Build and internalize appropriate algorithms and techniques
* Develop and implement statistical learning models
* Expand knowledge of quantitative biology capabilities across R&D
* Contribute to and lead local and global projects
* Engage with external collaborators via publications and presentations

Essential for the role
We believe that your focus is set on solving challenging problems through partnerships. You are a specialist in your field and you know that the best results are achieved by utilizing the strengths of every individual. You have the ability to operate effectively in a multi-disciplinary research environment. You enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.

* Excellent interpersonal skills, especially when communicating statistical concepts to non-statisticians
* Experience in data analysis and knowledge of at least some of the following areas: experimental design, linear/nonlinear models, Bayesian methods, statistical learning/artificial intelligence and modelling
* Programming experience with tools such as R, Shiny, Julia, Stan or similar
* PhD or equivalent in statistics, mathematics, data science or similar

The seniority of the role can be adjusted depending on your previous experience and skills.

Why AstraZeneca Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centres. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

So, what's next!
If this sound like the position and place for you - apply today!

We look forward to learn more about you. Send in your application as soon as possible. We will review applications continuously.

For more information about the position please contact the hiring manager Peter Konings, https://www.linkedin.com/in/peter-konings/.


Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
AstraZeneca R&D: https://www.astrazeneca.com/r-d.html



#DS&QuBi;

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Clinical Pharmacometrician in CVRM

Forskare, farmakologi
Läs mer Jun 21
Do you have expertise and experience in PK and PKPD, mathematical/statistical modelling and simulation, Model Informed Drug Development (MIDD) and its application in drug development? Would you like to apply your knowledge in a company that is following the science and turn ideas into life changing medicines? Then this might be your next challenge!

We now have an exciting opportunity for an engaged and diligent individual to join our growing Clinical Pharmacology and Quantitative Pharmacology (CPQP) team at AstraZeneca at our vibrant Gothenburg site in Sweden, as a Senior Scientist, Associate Director or Director depending on your background, experience and skills.

This is a global role that will support large- and small molecule projects across all phases of clinical development within the therapy area of Cardiovascular, Renal and Metabolism.

Within the Clinical Pharmacology and Safety Sciences (CPSS) function at AstraZeneca, we have a state-of-the-art Clinical Pharmacology and Quantitative Pharmacology (CPQP) organization with a diverse and uniquely skilled team of clinical pharmacometricians and clinical pharmacology scientists. You will thrive in an environment that inspires innovation, encourages multidisciplinary team-working and collaboration with academia, and rewards original scientific thinking.

What you will do
Working closely with clinical pharmacologists, physicians, statisticians and other scientists, you will apply model informed drug development (MIDD) to contribute to clinical programs, to support the design and interpretation of clinical studies and influence key decisions in early and late clinical development.

The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. Use of simulations and pharmacometric/statistical analyses to inform trial and program designs and decisions are important focus areas for us.

In collaboration with clinical pharmacologists, you will represent CPQP in cross-functional clinical project teams and be responsible for identifying and executing model informed drug development opportunities, to accelerate and inform decision making. Based on your interest, skills and experience, you might also take on strategic planning and delivery of the clinical pharmacology strategy acting as a dual Clinical Pharmacometrician/Clinical Pharmacologist. You will communicate your findings within and outside of AstraZeneca and publish in peer reviewed journals.

Minimum requirements for the role

* PhD or equivalent (M.Sc. or Pharm.D.) in pharmacometrics or mathematical/statistical modeling and simulation or other relevant area
* Strong technical knowledge and hands-on skills in modeling and simulation
* Biological understanding of disease and drug action
* Good oral and written communication skills

Desirable in the role

* 3+ years of industry experience or equivalent in quantitative modelling and its application in drug development
* Track record in creating and delivering on MIDD strategies in clinical drug development programs for both small and large molecules
* Early and late phase clinical development experience
* Understanding of clinical pharmacology aspects of drug development, preferably in both a small and large molecule setting
* Recognized scientific expertise demonstrated by scientific publishing in the field of clinical pharmacology

We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your skills, abilities and contribution. You have a real passion for your subject, along with a collaborative nature and ability to work in multi-disciplinary global teams.

Why AstraZeneca?
We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. Collaborate in an inclusive environment, a place full of bold new opportunities. Be empowered to be innovative and creative where difference is valued.

So, what's next? If the sounds like the job and place for you - apply today!
We look forward to find out more about you. Send in your application as soon as possible, we will review applications continuously.

For more information about the position please contact the hiring managers, Angelica Quartino (https://www.linkedin.com/in/angelica-quartino-352a7b2/) or Ann-Charlotte Egnell (https://www.linkedin.com/in/lotta-egnell-9595b0a/)

Where can I find out more?

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg site: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Read more about BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html
Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/

#DataAI

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Business Support Coordinator

Chefssekreterare
Läs mer Jul 4
Are you an admin professional that find motivation is supporting others? Would you love a flexible work where you get the opportunity to play a meaningful role for our Senior Leaders every day? Then, join us at AstraZeneca and Development Operations.

Development Operations brings together all the skills groups to drive critical operational activities for early and late stage medicines development. We are nearly 2,500 people operating in more than 45 countries across the globe - partnering with the early and late Therapeutic areas to meet the demands of extensive clinical trial programmes involving many thousands of patients.

We are now looking for a new Business Support Coordinator to join the team, reporting to the Business Support Manager. The position can be based at either of our sites in Gothenburg or Warsaw.

The role as Business Support Coordinator is a phenomenal opportunity to take on a challenging and varied role within our admin team. Your focus will be on providing high quality professional administration support to senior leaders within Development Operations. You will be working proactively together with the other co-ordinators in the function and possibly also more broadly within BioPharmaceuticals R&D. To be successful in the role you have experienced from working in a global complex environment and customer service is something you like in your every day job. .



Your accountabilities:

* Provide support to senior leaders, coordinating complex meetings and off-site events, diary arrangements and travel in line with AZ policy
* Work collaboratively with Global Colleagues to deliver a lean, consistent and professional global support service, including knowledge sharing and training within the Business Support team
* Be an expert in using technology to efficiently complete tasks and propose technology based solutions
* Control projects under general guidance ensuring delivery of project outputs according to plan, reviewing and refining plans as necessary

* Independently and pro-actively resolve issues and challenges, ensuring delivery of day-to-day support activities and programs
* Prepare documents, materials and official information releases and distribute to the required stakeholders
* Plan, organize, and schedule own workload, so that all activities are completed accurately and on time while using and developing best practices



Essential requirement for the role:

* Significant administrative or related experience
* Good communication and coordination skills
* Experience with a variety of virtual meeting technologies, information management software, and Microsoft products
* Ability to manage multiple projects/tasks/assignments simultaneously and effectively
* Demonstrated skills and ability in PC applications
* Strong customer service skills
* Independent follow-up on action items from meetings
* A high degree of personal credibility when interfacing with organizations internal and external to AZ
* Experience working in a fast-paced global environment

Desirable experience for the role:

* Experience of working in a pharma or healthcare environment
* Experience managing SharePoint sites including creating and managing permission groups, creating new sites, and adding design elements



So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

We welcome your application by July 13th at the latest.



Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

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Passionate Team Lead striving to make a greater impact

Laboratoriechef
Läs mer Jun 15
Are you a curious scientific leader seeking a role where your expertise can make an outstanding impact? Join a place built on innovation and creativity. Where different views and perspectives are encouraged and valued. An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.

We are looking for a Associate Director - Team Lead to join our Compound Management group - a delivery focused team where we collaborate to support projects aiming to impact patients' lives. We are responsible for the quality assurance, processing and timely provision of chemical compounds to AstraZeneca's drug discovery projects. The position will be placed at our vibrant AstraZeneca R&D site in Gothenburg, Sweden.

We belong to Discovery Sciences - our wider function that applies deep technical expertise in specialist technologies to support the delivery of targets and molecules to the early AstraZeneca pipeline.

What you'll do:
This position will give you the opportunity to lead a team of enthusiastic scientists, delivering critical support to projects using automated and digital technologies. Continuous improvement permeates everything we do and you will have opportunities to develop and implement innovative technologies and processes.

Designing, performing and interpreting experiments to investigate process improvements and evaluate new technologies is included in the role. We also rely on you to establish successful and productive relationships with local, global and external scientific colleagues and support services to ensure reliable delivery to projects.

Other responsibilities as Associate Director - Team Lead in Compound Management:

* Lead a team of lab-based scientists to support projects according to agreed needs and priorities.
* Develop and coach staff to deliver against departmental objectives and build a successful team.
* Apply your strengths to make impactful personal contributions to the delivery and productivity of the team.
* Develop the strategic direction of the department, and lead initiatives to deliver the strategic plan, achieve scientific excellence and develop the external reputation of Compound Management.

We strongly believe that everyone contributes with a unique set of competence. Your passion for the personal development of yourself and members of your team, combined with support from colleagues, mentors and managers, will ensure you are set up for success in this role.

Essential for the role:
Compound Management is a highly collaborative group, working to tight delivery schedules, so the ability to be comfortable working at a fast, goal-oriented pace, with a team focused approach is crucial to be successful in the role. Furthermore, you have excellent communication skills and a proactive and delivery focused approach. You are passionate about both your own personal development and the development of your team. We also believe you have:

* A MSc/PhD in a scientific subject area, or equivalent experience.
* Leadership and communication skills and a sincere passion for science, technology and innovation.
* Management of risk using evaluative judgments in complicated or novel situations.
* An understanding of drug discovery.
* A strong customer and delivery focus with ability to build trusted relationships with internal and external scientific colleagues.

Desirable for the role:

* Knowledge and experience of working in a sample management role.
* Experience of complex robotic and automated systems, advanced liquid handling instrumentation and laboratory operating systems.

Why AstraZeneca?
Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.

So, what's next! If this sounds like the place and job for you - apply today!

We look forward to find out more about you - make sure you apply no later than the 1st August, 2022.

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38

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