Astrazeneca AB jobb i Göteborg

Are you passionate about Machine Learning and AI? Do you have the expertise to lead and inspire a high-performing enterprise AI team?

The role
As an AI Team Lead, you will be responsible for leading and inspiring a team of AI Engineers in Gothenburg, developing state-of-the-art reusable AI services and assets. You will join the Enterprise Reusable AI Services leadership team, providing deep technological leadership to engineers and stakeholders alike. This role will involve a high degree of collaboration to ensure that ML/AI products and pipelines can be leveraged by other engineering teams and problems tackled collectively across the group.



Reusable AI Services focuses on solving optimisation, language, timeseries and multi-modal problems at scale, engineering solutions that promote reuse and respond to high-impact business challenges. You will be responsible for realising delivery excellence best practices across Reusable AI Services and influencing internal and external stakeholders with the goal of delivering state-of-the-art and adopted AI services in partnership with your peers.



Key Accountabilities:

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Lead and inspire a team of AI Engineers based out of Gothenburg, developing state of the art reusable AI services and assets, working in partnership with other AI leads spanning the domains of natural language processing, mathematical optimisation, time-series, multi-modality and new AI innovations.

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Lead best practices around agile AI product development and contribute towards the structuring and planning of key AI deliverables across the Reusable AI Services portfolio.

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Work with other AI teams to develop reusable delivery patterns and partner with our AI platforms teams to ensure that engineers have access to relevant infrastructure and support

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Contribute towards the delivery of cross-functional AI products, working to translate business gaps and requirements into hardened and estimated technical briefs that deliver value to AstraZeneca.

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Lead and contribute towards reusable software products deployed in impactful business processes with realised annualised $ value and time savings.

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Develop effective relationships with senior stakeholders to ensure effective utilization of resources and services in multiple projects.

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Foster AI and software engineering excellence in the engineers that you work with, from support on model research, system design, leading technical workshops and contributing to the research and development of state-of-the-art AI models.

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Become a visible AI leader with AstraZeneca, collaborating across the community to develop best practices and cross functional opportunities that drive value.

Essential Skills/Experience:
The ideal candidate will have a background as a senior AI engineer or data scientist and have significant experience in structuring and leading agile AI products and services. We see that you have experience leading the planning and execution of complex AI products within high performing engineering teams. This experience will be called on to coach other AI teams on product lifecycle development and used to streamline delivery patterns and ways of working on a portfolio of complex AI deliverables. The candidate will be expected to identify and translate customer demand into detailed and actionable software briefs and help to articulate customer benefits when securing their sponsorship and support. Experience developing AI in a regulatory or compliance setting is desirable with an appreciation for the documentation and diligence required to deliver ethical AI responsibly. Experience of developing and running machine learning models using cloud platforms, building APIs and familiarity with the challenges of deploying web services for different audiences will also be key.

We also see that you have:

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Bsc/MSc/Ph.D degree in Computer Science or related quantitative field

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Experience leading and managing junior and mid-level colleagues, delivering technical workshops and providing advanced technical mentorship.

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Experience modelling complex datasets in applied business and/or scientific application domains, resulting in the development of state-of-the-art AI algorithms and applications

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Advanced software development skills in Python as well as, ideally, other languages, and familiarity with database systems (e.g. , No, graph)

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Proven expertise and leadership in software development best practices and principles (software architecting, linting, CI/DI, unit tests, OOP, Git)

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Understanding of algorithm design, development, optimisation, scaling and applications.

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Experience building, managing and delivering against a cross-functional portfolio of customer demands and requirements

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Excellent written and verbal communication, business analysis, and consultancy skills

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Ability to work with various senior business and technical stakeholders, forging buy-in and sponsorship towards team initiatives and innovations

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Passion for advising on best-in-class delivery patterns that enable AI developers to do their best work

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Strong bias for action and results


Ready to make a difference? Apply now but no later than October 14th and join us in our journey to discover the next life-changing medicine!

Are you a highly motivated scientist who would like to dedicate your passion for science and your capabilities to discovering novel therapies for patients? We have an opening to join us as a Research Scientist in the Assays, Profiling & Cell Sciences department within the Discovery Sciences organization in Gothenburg, Sweden. You will have the opportunity to apply proven molecular biology and cell biology expertise to contribute to the discovery and development of therapeutic oligonucleotides, such as antisense oligonucleotides (ASOs) and small interfering RNA (siRNA), and their Targeted Delivery to relevant tissue, in a highly collaborative environment.

The successful candidate demonstrates a passion for delivery to team objectives, combined with strong team working ethics, and thrives from working in drug discovery projects. You will join a team whose remit is to support our drug discovery projects globally with early DMPK assessment, SAR profiling and in-depth mechanism of action data. We offer a highly rewarding scientific environment with ample learning opportunities.

You will be strongly encouraged and supported to think creatively in our dynamic environment. Here, we are free from fear of failure, free to ask the right questions and make bold decisions.


What you will do:
This is a lab-based role focused on generating in vitro data on therapeutic oligonucleotides in support of drug discovery projects. The work includes independent troubleshooting and timely reporting of data according to agreed timelines. All work is conducted in dialog with project teams, where you are expected to present and contribute in advancing the project science, specifically in support of the Cardiovascular, Renal and Metabolism as well as Respiratory & Immunology disease area organizations.

For this role, we seek a candidate with experience in the development and/or application of assays for quantitative measurements of RNA transcripts. The candidate will reinforce our team for discovery and development of therapeutic oligonucleotides (naked and conjugated oligos).


Essential for the role:

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MSc or PhD degree in Biology or related Science.

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1 to 3 years of additional experience in Biotech/Pharma.

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Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment.

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Knowledge of oligonucleotide modalities.

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Experience in the development and/or application of assays for quantitative measurements of RNA transcripts.

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Independent analysis and evaluation of complex data and delivery of data to agreed timelines.





Desirable for the role:

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Previous experience working with siRNA or ASO.

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Experience with imaging assays to localise and quantify protein levels.

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Good understanding of precision delivery of active compound to relevant tissue.

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Previous experience working with various cell types including primary cells and iPSCs.





Why AstraZeneca in Gothenburg?
You can ask anybody who has ever set foot here - our Gothenburg site has a vibrant culture that pulls you in! It is a mix of both local and international talent. We welcome the contribution of people from all backgrounds, beliefs and walks of life.

So, what's next? If this sounds like your next challenge - please apply today!

We look forward to your application, but please send it to us no later than October 9, 2024.

For more information about the positions please contact hiring manager David Gilot at +46 72 206 97 40 or david.gilot@astrazeneca.com.

Are you a dedicated Scientist who is passionate about experimental work, scientific excellence, and innovation? Do you want to be part of a team committed to providing quality data to drive chemistry optimization in drug discovery projects? Then this might be your next challenge!


We are looking for a passionate Research Scientist to join us in the Assays, Profiling & Cell Sciences department within the Discovery Sciences organization in Gothenburg, Sweden. Our focus is to provide quality data to drive chemistry optimization in drug discovery projects. Leading from the bench, you will combine good communication and team-working skills with a passion for experimental work, scientific excellence, delivery and innovation.

You will be encouraged and supported to think creatively in our dynamic environment. Here, we are free from fear of failure, free to ask the right questions and make bold decisions.

What you will do:
This is a lab-based role focused on supporting our drug discovery projects with quantitative measurements of intracellular protein levels and their turnover using high resolution mass spectrometry to understand response to treatment. The work includes independent troubleshooting and timely reporting of data according to agreed timelines. All work is conducted in close dialog with project teams, specifically in support of the Cardiovascular, Renal and Metabolism as well as Respiratory and Immunology disease area organizations locally in Gothenburg.

Essential Requirements:

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MSc or PhD within a relevant scientific discipline or demonstrated relevant experience in the Life Science industry
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Hands-on experience of working with and trouble-shooting high-resolution protein mass spectrometry equipment
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Practical knowledge of targeted or global proteomics analysis
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Excellent communication skills and an ability to operate effectively in multi-disciplinary research environment
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Independent analysis and evaluation of complex data and delivery of data to agreed timelines
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First-rate decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity



Desirable for the role:

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Experience in protein sample preparation from cell lysates and tissues and a thorough understanding of available approaches for enrichment
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Experience with proteomics data analysis approaches
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Experience in protein turnover measurements using the SILAC approach
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Practical knowledge of design, development and validation of cellular assays for compound profiling
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Experience in the area of cell biology, in vitro pharmacology and protein homeostasis



Why AstraZeneca?
At AstraZeneca, we follow the science to explore and innovate. We are committed to treating, preventing, modifying and even curing some of the world's most complex diseases. Our team is driven by our desire to understand and reveal new insights. We are always learning from those living with diseases and harnessing digital, data science & AI to fast-forward our research. Join us as we push the boundaries of science to deliver life-changing medicines.



So, what's next? If this sounds like your next challenge - please apply today!

We look forward to your application, but no later than October 15, 2024.

For more information about the position please contact hiring manager Linda Sundström at linda.sundstrom@astrazeneca.com.


Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

AstraZeneca is committed to the development of the next generation of innovative medicines. The New Modalities Medicinal Chemistry team is part of the department of Medicinal Chemistry, Respiratory & Immunology (R&I) at AstraZeneca R&D, Gothenburg, Sweden.



The New Modalities team works on peptides, oligonucleotides and conjugates in close collaboration with Computational Chemists, Analytical Chemists, Biologists, DMPK, Safety and Pharmaceutical scientists - all joined up by the goal to discover synthetic therapeutics of the future.

We seek to recruit a Director, New Modalities Medicinal Chemistry, in the therapeutic area of Respiratory & Immunology. This is a very exciting opportunity as it combines Medicinal Chemistry of peptides and oligonucleotides, the development of cell- and tissue targeting moieties and the development of diverse types of conjugates. This position will be on-site in Gothenburg, Sweden and will not have the ability to be located remotely.



What you'll do?
The Director, New Modalities Medicinal Chemistry leads a team of 10 PhDs who share a strong experience in peptides, oligonucleotides, targeting ligands and conjugation. As an experienced expert in the field of peptide and/or oligonucleotide drug discovery the successful candidate is expected to make significant contributions to early target validation, the design, optimization and delivery of peptide and oligo drug molecules for AZ´s new modality portfolio and new science around synthetic New Modalities.

The Director, New Modalities Medicinal Chemistry will have a significant impact on portfolio projects across the R&I peptide and oligonucleotide portfolio. As part of the role he/she will lead a multidisciplinary, highly collaborative and international team and represent the department in global scientific initiatives defining strategic direction and implementing new technologies in New Modalities. The successful candidate will host MSc/PhD students and postdocs, work with multiple academic and industrial partners and publish/patent and regularly present at internal and external conferences.



Major Duties and Responsibilities include:
* Impact on R&I´s project portfolio of synthetic New Modalities (peptides, oligonucleotides & conjugates)
* Co-lead drug discovery projects and collaborate in crossfunctional teams
* Generation/support of new target/project proposals
* Advise project teams and senior leaders around peptides, oligonucleotides and conjugates
* Lead, develop and mentor a team of 10 New Modalities PhDs
* Initiate and lead collaborations with external and internal partners
* Publish and present internally and externally
* Manage performance and career development of direct reports

Essential requirements:
* PhD in Organic Chemistry, Medicinal Chemistry, Biochemistry or Chemical Biology
* Demonstrated expertise in design, synthesis and characterization of peptides and/or oligonucleotides - the team searches an expert in either peptides, oligonucleotides or both
* Expertise in pharmaceutical drug discovery and development of new modalities drug candidates
* Extensive interdisciplinary knowledge of drug discovery
* Experience in modern analytical, biophysical, structural chemistry and computational techniques
* Excellent leadership and interpersonal skills
* Excellent written and verbal communication skills



Why AstraZeneca?
As we know employees are critical to our current and future success, we are dedicated to being a great place to work and we offer competitive benefits and services. You are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There is no better place to make a difference to medicine, patients and society. AstraZeneca has an inclusive culture that champions diversity and collaboration - always committed to lifelong learning, growth and development.

What's next?

This is an exciting opportunity to join a strong, dynamic team and support the portfolio of a major pharmaceutical company that has science at its heart whilst being based in the beautiful city of Gothenburg, Sweden.



If you are ready to make a difference - apply today, and we'll make it happen together! We would be delighted to receive your application until October 6, 2024.
For more information about the position please contact: Dr. Werngard Czechtizky, Head of Medicinal Chemistry, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg at Werngard.Czechtizky@astrazeneca.com.



Where can you find out more?
https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/

Do you have a statistical expertise and in-depth knowledge within pharma or healthcare? Would you like to combine your leadership skills with your understanding of the technical and regulatory requirements of drug development in a global company that follows the science and turns ideas into life changing medicines? Join us then at AstraZeneca to develop the future treatments of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

We now offer an exciting opportunity for a Biometric Team Lead with passion, expertise, and experience in developing, coaching, and mentoring a team of fantastic statisticians.

The role will be based in Gothenburg SE.

What you'll do

The Biometrics Team Lead is responsible for the biometrics contribution in one or more drug projects across all phases of development and is line managing a group of statisticians. You will have 6 -10 statisticians directly reporting to you.



Major Responsibilities

In the role, you will:

* Lead the strategic and operational planning of the CVRM Biometrics contributions, to the Development Plans, Regulatory Strategy and Submissions, Health Technology Assessment and Commercial support of AZ products
* Provide leadership for Biometrics staff world-wide so that all work is carried out with regards to AstraZeneca standards and external regulations
* Performance management of your direct reports
* Coach your direct reports to rapid professional development
* Provide leadership and direction to improvement projects/activities/initiatives and drive the implementation of best practice across the department
* Together with your team lead colleagues secure biometrics contribution to the whole CRVM development portfolio
* Represent AstraZeneca to Health Authorities and Reimbursement/Payer organizations
* Investigate and implement statistical approaches, for relevant statistical issues and/or regulatory guidance and/or value demonstration
* Develop contacts with international opinion leaders, consultants and collaborative groups Organizations



Essential for the role

* MSc/PhD in Statistics or Mathematics -containing a substantial statistical component
* Experience in line management and/or project management
* In depth knowledge of the technical and regulatory requirements related to the role of statistician in drug development
* Extensive experience of drug development, program design, data analysis and interpretation
* Experience of regulatory interactions and/or submissions
* In order to be successful in the role as Biometric Team Lead in our organization, we believe that you are a skilled communicator and that you have an excellent ability to build strong relationships. You are also a talented collaborator in order to work across global & functional boundaries, both internally and externally.



So, what's next?

Are you already imagining yourself joining us? Good, because we can't wait to hear from you! Welcome with your application (CV and cover letter) no later than September 30, 2024.

We will review the applications continuously so please apply as soon as possible.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity, no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

About our Postdoc Programme

Bring your expertise, apply your knowledge, follow the science, and make a difference. AstraZeneca's Postdoc Programme is for self-motivated individuals looking to deliver exciting projects in an encouraging, engaging, and innovative environment. You'll work with multidisciplinary scientific teams from a diverse set of backgrounds and a world-class academic mentor specifically aligned to your project. Our postdocs are respected as specialists, encouraged to speak up, and supported to share their research at conferences, publish papers, achieve their goals.

Make a more meaningful impact in your career, with greater ownership and accountability to contribute whilst making a difference to the lives of our patients!

This is a 3-year programme, with an initial 2-year period and a 1-year merit-based extension.



About the Opportunity

The primary objective of this position is to offer an emerging researcher an exceptional opportunity for advancing the expertise and proficiencies where biocatalysis is used to modify small molecule drug properties. Postdoctoral fellows assume a pivotal role in propelling scientific understanding and catalysing innovation within the pharmaceutical and biotechnology sectors.

The candidate selected for the postdoc role will become an integral part of AZ's Compound Synthesis and Management Department, within Discovery Sciences (DS), which collaborates closely with the Pharmaceutical Sciences and the CVRM and RIA Therapy areas, all part of BioPharma R&D. You will work together with experts in small molecule organic synthesis, automation, analytical chemistry and protein engineering and take part in a fantastic collaborative research environment which accommodates graduates, PhD candidates, visiting scholars, fellow Postdocs, and staff scientists.



Project Focus

This project will conduct pioneering research in the discovery of biologically active small molecule hits and lead compounds using biocatalysis with methyltransferases and related enzymes. We aim to develop robust routes so the small-scale synthesis of alkylated compounds for probing both SAR and drug-like properties.

Our Postdoctoral fellow will form a collaborative nexus with accomplished interdisciplinary scientists from AstraZeneca, led by Prof. Martin Hayes (Discovery Sciences) an expert in biocatalysis, Dr Giulia Bergonzini (Director, Synthetic Chemistry). In addition, you will receive academic mentorship from Bernhard Hauer (Professor, University of Mainz) and Uwe Bornscheuer (Professor, University of Greifswald).



What You'll Do

As a postdoctoral fellow you will pioneer and lead research aimed at advancing ground-breaking biocatalytic chemistry using methyl(alkyl) transferases for the late stage modification of early stage hit/ lead small molecules.

You will take part in collaborative efforts with other departments in AstraZeneca and with external technology providers to prosecute the development of these biocatalysts as credible catalysts for use in industry.



Key Duties & Responsibilities:

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Devise strategies for the implementation of innovative reactions with C- and N-methyltransferases for the selective modification of C-H bonds in small molecule libraries
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Use automation, miniaturisation and data analytics to build workflows and understanding for how enzyme library vs substrate library screening will be efficiently performed
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Plan, draft and publish impactful paper in high impact scientific journals and skilfully present research findings internally and at external conferences
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Opportunities to mentor PhD students, graduate scientists, and master thesis students



Qualification, Skills & Experience

The AZ Postdoc programme is aimed at individuals who are either:

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Not more than 5-years after completing their doctoral degree (PhD, DVM, or MD) - PhD already awarded, or
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Postgradute Students, about to obtain doctoral degrees (the PhD must be awarded within 6 months of joining AstraZeneca)



Essential Requirements

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A PhD, or equivalent in biocatalysis, enzyme engineering, organic chemistry or a related field
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Passionate about science - Your ability to conduct independent and innovative research is vital
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Established track record of research productivity, substantiated by proven publication record and/or presentations
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Experience in designing and executing experiments, as well as strong analytical and problem-solving skills
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Excellent written and verbal communication skills
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Exceptional collaborator - Working effectively in a team, exchanging ideas, and contributing to joint research efforts



Desirable Requirements

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Proficiency in synthetic organic chemistry and protein engineering
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Experience with analytical tools esp. HT-LCMS, NMR
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Interest in data and workflows, and application of ML to biocatalysis
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Experience of modelling, docking, MD tools as applied to biocatalysis



If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be.

The advert will be open from September 10, 2024 and, we welcome your application as soon as possible, but ahead of the scheduled closing date of October 1, 2024. In the event, that we identify suitable candidates ahead of the scheduled closing date, we reserve the right to withdraw the vacancy earlier than published.

Postdoctoral Fellow: Molecular Modelling & Machine Learning

Location: Gothenburg, Sweden

Competitive Salary, Bonus & Benefits Package



Do you have expertise in, and passion for Machine Learning, Computational Chemistry, Chemo-informatics or Immuno-informatics? Would you like to apply your expertise to impact computational immunology assessment in a company that follows the science and turns ideas into life-changing medicines? Then AstraZeneca might be the one for you!


About the Opportunity

In this exciting Postdoctoral Fellow position, you will research and develop computational tools for the prediction of immunogenicity risk for peptides and proteins incorporating non-natural amino acids.

This project is supported by the Computational Chemistry team within the Early Respiratory & Immunology function, which is centered on delivering life-changing products that improve health and fight and cure diseases. This team sits within the Medicinal Chemistry Department and supports all the pipeline development projects within the therapeutic area for small molecules and new modalities (peptides and oligonucleotides). The team also collocates in the Gothenburg in-silico Center of Excellence with dozens of other experts in the use of computational methods for drug-development.

This project is also supported by the Clinical Pharmacology & Safety Sciences (CPSS) group that works across all of AstraZeneca's therapy areas from early-stage drug discovery to late-stage clinical development.

The project will be in collaboration with an academic institution specializing in computational immunogenicity tools.
This is a 3-year program.



What you will do

Our Postdoctoral Fellow will conduct ground-breaking research using structure-based modelling and machine learning methods for prediction of immunogenicity. You will develop computational tools for immunogenicity assessment suitable for peptides and proteins incorporating non-natural amino acids. This will involve structural modelling of peptide-protein interactions, advanced computational methods to calculate binding affinities (e.g. Free Energy Perturbation) and utilizing state-of-the art machine learning techniques (e.g. transfer learning neutral networks).


Key Duties & Responsibilities:

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Research, design and implement innovative computational tools for immunogenicity assessment of peptides and proteins incorporating non-natural amino acids.
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Lead and drive the project under the supervision of cross-functional AstraZeneca team and in collaboration with the academic expert.
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Plan, write, publish, and present high-quality scientific papers.
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Participate in function and department activities in AstraZeneca, learn about drug discovery and development processes and get exposure to new scientific advances.


Essential Requirements

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PhD degree, or equivalent in computational biology / chemistry, or cheminformatics (with a significant data science component), or mathematics / machine learning.
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Experience with structure-based molecular modelling.
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Good knowledge of machine learning methods and data science concepts.
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Proficiency in programming (preferably Python).


Our Postdoc programme is aimed at individuals with a strong publication record who are either:

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Within 5-years of obtaining their doctoral degree (PhD, DVM, or MD) - PhD already awarded, or
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Students, soon to obtain doctoral degrees (the PhD must be awarded within 6 months of joining AstraZeneca).


Desirable Requirements

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Proven knowledge of one or more of the following areas: Immuno-informatics, Computational biology, Cheminformatics or Computational chemistry
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Excellent written and oral communication skills
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Strong planning, organizational and time management skills
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Ability to work effectively in a multidisciplinary research environment.


Reasons to Apply

You will work with the innovative technology in a highly collaborative environment to apply novel ideas to answer important questions addressing the safety of biological medicines. Immunogenicity represents a potential undesired safety risk for new biological therapeutic modalities. New modalities such as peptide-based therapeutics and antibody-drug conjugates frequently include non-natural amino acids. It is currently not possible to assess the immunogenicity risks resulting from such modifications computationally. By developing in silico tools to assess this risk you will help to deliver efficacious and safe medicines for our patients.

You will have several opportunities to work in collaboration with supportive cross-functional internal and external academic partners and engage with the external community, through publications in high-quality journals and presentations at conferences.

As a respected specialist, we will empower you to take appropriate risks, lead the project and "run with it", along with providing you will all the support you need.




On-Site Working

The position is located at our research site in Gothenburg, Sweden.

As a key member of a research group and taking a leading role on a Postdoctoral project, we expect regular attendance - a minimum of 3 days per week on the AstraZeneca campus. For laboratory-based scientists, this may be higher.


Next Steps

This advert will be running from August 26, 2024 and we welcome your application as soon as possible, but ahead of the scheduled closing date of September 15, 2024. In the event, that we identify suitable candidates ahead of the scheduled closing date, we reserve the right to withdraw the vacancy earlier than published.

Are you a passionate scientist with expertise in mathematical modelling and pharmacokinetics-pharmacodynamics (PK/PD)? Do you want to contribute to the development of future treatments for cardiovascular, renal, and metabolic diseases? If so, we invite you to join our Modelling & Simulation team within the Early Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca. This position is based at our dynamic R&D site in Gothenburg, Sweden.



Accountabilities:

As a Modelling and Simulation PK/PD Scientist, your role involves supporting drug project teams in selecting the appropriate target, molecule, dose, patient population, and development strategy. You will design studies in preclinical disease models and apply suitable mathematical modelling approaches to provide quantitative PK/PD insights. Working closely with your cross-functional team, you will integrate relevant data to predict human pharmacokinetics, efficacious drug exposure, dosing regimen and longitudinal response, and present results to internal governance bodies. In addition to these responsibilities, your role entails driving our strategic DMPK innovation projects and communicating scientific progress both internally and externally.



Essential Skills/Experience:

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PhD in pharmacokinetics, pharmacology, mathematics, or related field, with a focus on model-based PK/PD approaches, preferably in a preclinical/translational setting
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Industry or academic experience in exposure-response modelling (PK/PD, NLME, PBPK and/or QSP) including hands-on experience with scriptable modelling softwares (e.g., Phoenix, R, Matlab, Python, Monolix, NONMEM)
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Demonstrated scientific leadership through a publication track record in relevant area
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Excellent interpersonal skills and the ability to work in cross-functional teams
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Excellent communication skills in English, both verbal and written



Desirable Skills/Experience:

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Experience in pharmaceutical research and development
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Experience in PBPK modelling (e.g. Simcyp or PK-Sim)
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Experience in defining quantitative modelling strategies across various therapeutic modalities (e.g., small molecules, oligonucleotides, peptides, proteins, antibodies or cell/gene therapy)



At AstraZeneca, we are driven by results and use our unique blend of science and commercial knowledge to spot opportunities and drive outcomes. We are part of an expansive healthcare ecosystem that connects key players across the entire patient journey. Our patient-first approach informs every decision we make. We are committed to your development and believe that your best is better here. Join us and be part of a global team filled with the smartest minds.



Ready to make your mark? Apply now and be a part of our journey to redefine the future of healthcare! Welcome with your application no later than September 15th, 2024.



For more information about the position, please contact hiring manager, Pär Nordell, at par.nordell@astrazeneca.com

Are you an experienced scientist ready to apply your skills in a diverse and dynamic company? If you can envision providing scientific expertise in a role that can impact patients' lives - join us now!

Our team is growing and we are now looking to recruit a Senior Scientist experienced in histology with a background in image analysis and ideally experience with pathological assessment of immune-mediated diseases. If you have a drive for innovation and idea generation as well as excellent laboratory skills, this is a great opportunity to join the Bioscience In Vivo Department within Early Respiratory and Immunology. The role is located at our vibrant R&D site in Gothenburg, Sweden.

Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases such as asthma, COPD, IPF, IBD, RA and SLE.

The successful candidate will join a highly motivated team that works closely together with other departments focusing on Target Translational Science, Bioscience In vitro assays and Drug Metabolism/Pharmacokinetics to support discovery projects and to drive new exciting research. Are you ready to join us?

What you'll do?
As a Senior Scientist you will be a vital member of the department and in various working teams to progress our respiratory and immunological drug discovery projects. You will actively take part in scientific discussions, gain input from others and be involved in multiple project meetings to present and discuss experimental plans and data.

This is a partly lab-based role where you will be actively involved in experimental phase of histological analyses, with responsibility to coordinate, perform and evaluate experiments as well as drive the establishment of new techniques. Characterization and validation of target expression and subsequent evaluation of engagement of the target by drug treatment in both patient and in vivo tissue samples will be key areas of your daily work. You will independently assess and report data with a clear understanding of its reliability, interpretation of findings and draw appropriate conclusions with input from others.

We are looking for a great teammate with strong background in histology and related image analysis techniques with a specific focus on autoimmune and autoinflammatory diseases, ideally complemented by some experience in pathology and pre-clinical drug discovery processes.

Essential for the role

*

PhD in a relevant field (area of Bioscience/Immunology) ideally complemented with experience of working in a drug discovery environment
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Strong experimental histology skills in performing immunohistochemistry, istochemistry, in situ hybridization (including RNAscope) with automated machines (e.g. Ventana Discovery Ultra and Leica Bond)
*

Experience with immune cell identification and characterization (cluster of differentiation antigens, transcription factors, cytokines, etc)"
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Knowledge in histology scoring and histomorphometry
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Proven knowledge and experience in image analysis platforms (e.g. Visiopharm and Halo)
*

Understanding of statistical methods, quality control and data reporting/archiving
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Be respectful, communicate openly and show effective collaborative behavior to obtain high quality study results
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Excellent written and oral communication skills, including presentation skills. You are organized and incorporate the views of others in your communication and collaboration



Desirable for the role

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Knowledge of immune-mediated diseases, with a specific focus on gut, skin, joint, liver and/or kidney immunity including target and mechanism knowledge and basic understanding of pharmacokinetics
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Some experience in pathology
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Good understanding of pharmacology, physiology and immunology
*

Familiarity with deep learning image analysis methods, e.g. image segmentation and classification
*

Practical experience with a scripting language (Phyton, R) modelling tools
*

Knowledge in advanced histological techniques such as spatial transcriptomics, hyperplex staining and tissue optical clearing



Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

What's next?
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until September 9, 2024.

Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Are you ready to make a meaningful impact on people's lives with life-changing medicines? We are seeking a Manager, Clinical Regulatory Writing (CReW) to join our Biopharmaceuticals R&D team. This role offers the opportunity to provide expert communications leadership to drug projects and author strategically important clinical-regulatory documents. You will be instrumental in supporting the Company's CVRM therapeutic areas in all phases of clinical development. Our vision is to be an industry leading organization driving strategic communication excellence to achieve successful submissions and approvals.



What you'll do

As a Manager, Clinical Regulatory Writing, you will lead authorship and ensure the timely delivery of high-quality clinical-regulatory documents. It is your task to ensure that relevant regulatory, technical, and quality standards are achieved, and that relevant processes and best practice are applied. It is important to have the ability to balance multiple tasks in parallel, potentially across several drug projects, and deliver on priorities.



You are expected to drive the clinical interpretation of data and information and condense it into clear, concise and accurate messages that address customer information requirements. As well as provide critical review of documents for correctness, clarity, completeness and compliance.



It will require you to proactively collaborate with other functions during document development, including, as needed, with external service providers/contractors. As part of a clinical delivery team, you will provide communications support to projects, establish communication standards and best practice, and continuously advocate for quality and efficiency.



Essential for the role

- Life sciences degree in an appropriate subject area.

- Experience in the medical/regulatory writing field gained in a pharmaceutical/biotech industry or CRO environment.

- Understand drug development and communication process from development, launch, and life cycle management.

- Knowledge of the technical and regulatory requirements related to the role.

- Excellent verbal and written communication skills in English.

- Flexibility in adapting to changing circumstances or new information.

- Ability to work independently with support of more senior members and/or as part of a team.



When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.



At AstraZeneca, we believe in turning our drug development strategies into reality. We work at all stages of development to translate our life-changing science into medicines to get the best results for AstraZeneca, patients in need and healthcare professionals. We are a diverse and open-minded team harnessing our different skills and experiences. Our differences enable us to explore new ideas and ways of doing things. It keeps us on our toes and excited for what's next. We are part of the solution, involved in key discussions, in our role we act as both a drug developer and Regulator. We think broadly about patients and what it takes to prevent and treat diseases to develop progressive solutions.



Are you ready to join a team with deep specialist knowledge and Regulatory expertise? We welcome your application no later than 31t August, 2024!

Join our R&D IT team as a Product Researcher / User Experience Designer, where you will be at the forefront of creating intuitive, user-friendly products that meet the needs of our end users. This role is pivotal in identifying business transformation opportunities through research, driving optimization, and unlocking new sources of value creation. With a focus on hypothesis-led, evidence-driven approach to value creation, you will work closely with cross-functional teams to drive user-centered design and research practices throughout the organization.

What you'll do:
As a Product Researcher and Designer, you will contribute to the development and execution of a comprehensive user research framework aligned with product and business goals. You will identify key research questions, methodologies, and timelines for research initiatives. Your role will involve conducting qualitative and quantitative user research studies, translating research findings into actionable insights, and designing wireframes, prototypes, and user interfaces. You will also advocate for user needs throughout the product development lifecycle and stay updated on industry trends related to user experience design and research.

Essential Skills/Experience:

*

Bachelor's or master's degree in Human-Computer Interaction, User Experience Design, Psychology, or a related field.
*

Proven experience (7+ years) in user experience design and research, preferably in an R&D and/or Pharma setting.
*

Deep understanding of user-centered design principles and best practices.
*

Proficiency in conducting user research studies.
*

Experience of UX tools and methods across the full user-centered design process.
*

Specialist technical skills in creating information architectures, flows and wireframes, interactive prototypes, moderating usability lab testing and other research methodologies.
*

Finely honed visual/ graphic design skills (color, typography, layout, illustration).
*

An excellent listener and presenter.

We believe the following experience is desirable:

*

Strong analytical and problem-solving skills.
*

Proficiency in design and prototyping tools such as Figma.
*

Experience with data analysis tools and techniques.
*

Excellent communication and presentation skills.
*

Ability to collaborate effectively with cross-functional teams and partners.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we are committed to making a meaningful impact. Our work has a direct impact on patients, transforming our ability to develop life-changing medicines. We empower the business to perform at its peak and lead a new way of working, combining cutting-edge science with leading digital technology platforms and data.

Join us at a crucial stage of our journey in becoming a digital and data-led enterprise. Make the impossible possible by building partnerships and ecosystems, creating new ways of working and driving scale and speed to deliver exponential growth.

AstraZeneca offers competitive salaries and excellent benefits, such as extra paid Holiday, Private Medical Benefit, on-site Work Out and much, much more.

Ready to make a difference? Apply now to join our team as a Product Researcher and Designer! We welcome your application no later than September 2nd.

Are you ready to be part of the future of healthcare? Can you think big, be bold, and harness the power of digital and AI to tackle longstanding life sciences challenges? Then Evinova, a new health tech business part of the AstraZeneca Group might be for you!

Transform billions of patients' lives through technology, data, and cutting-edge ways of working. You're disruptive, decisive, and transformative. Someone excited to use technology to improve patients' health. We're building a new Health-tech business - Evinova, a fully-owned subsidiary of AstraZeneca Group. Evinova delivers market-leading digital health solutions that are science-based, evidence-led, and human experience-driven. Thoughtful risks and quick decisions come together to accelerate innovation across the life sciences sector. Be part of a diverse team that pushes the boundaries of science by digitally empowering a deeper understanding of the patients we're helping. Launch pioneering digital solutions that improve the patients' experience and deliver better health outcomes. Together, we have the opportunity to combine deep scientific expertise with digital and artificial intelligence to serve the wider healthcare community and create new standards across the sector.

The Product Engineering organization consists of several self-organized/managed cross-functional teams with the people and skills needed to deliver our innovative digital products and solutions to patients and healthcare providers participating in clinical trials around the world. We are working with agile methodology delivering a new release of the software product with program increments every quarter.

We are proud to have one of the best software development teams you can find with deep technical and business skills to shape the product from early ideas and requirements through full implementation and support. This is a place where you can grow and learn together with other people delivering software with a great purpose.

About the Role
We are seeking a squad lead with strong leadership skills, technical expertise, and the ability to work closely with other squads and tribes within the organization. You will be responsible for leading a team of talented developers working on web and mobile frontend applications and backend-for-frontend-services. The team is part of a larger programme containing a web portal, mobile apps, medical devices integrations, content management system, app configurations and many more integrations. You will play a critical role in ensuring the successful delivery of high-quality software products while fostering a collaborative and innovative team environment.

Key responsibilities include:

* Lead and mentor a team of software engineers, testers, design and business analyst
* Ensure collaboration and effective communication within the squad and across other squads and tribes
* Provide technical guidance and support to the squad
* Collaborate with architect and senior engineers to design and implement scalable and maintainable solutions
* Work closely with product owner to define and prioritize the squad's backlog and ensure they are met with the software solution
* Prepare and lead planning and other scrum activities, progress tracking and risk assessment
* Leading the delivery of software solutions aligned to regulatory requirements, product roadmaps and goals on time
* Participate in cross-tribe initiatives and contribute to the overall success of the engineering organization
* Assist tribe lead with recruitment of new team members
* Hold team building workshops and activities
* Promote a culture of continuous learning and development
* Identify and implement process improvements to improve productivity and efficiency

Minimum Qualifications:

* Msc in computer science / information technology / engineering
* More than 8+ years of Software development experience
* More than 3+ years of confirmed experience of leading people
* Proven experience in frontend technologies such as React, Angular or Vue.js
* Experience with mobile development frameworks such as React Native, Flutter is a plus
* Solid understanding of RESTful APIs, microservices architecture, and cloud platforms (e.g. AWS, Azure)
* Significant experience of using Agile approaches (SAFE & Scrum)
* Strong problem-solving and decision-making abilities
* Effective communication and interpersonal skills
* Ability to work collaboratively in a fast-paced and dynamic environment

Desired Qualifications:

* Regulatory knowledge, i.e GxP, SaMD validation or similar
* Scrum master / Agile coach Certification
* Native iOS / Android


Why Evinova (AstraZeneca)?
Evinova draws on AstraZeneca's deep experience developing novel therapeutics, informed by insights from thousands of patients and clinical researchers. Together, we can accelerate the delivery of life-changing medicines, improve the design and delivery of clinical trials for better patient experiences and outcomes, and think more holistically about patient care before, during, and after treatment. We know that regulators, healthcare professionals, and care teams at clinical trial sites do not want a fragmented approach. They do not want a future where every pharmaceutical company provides its own, different digital solutions. They want solutions that work across the sector, simplify their workload, and benefit patients broadly. By bringing our solutions to the wider healthcare community, we can help build more unified approaches to how we all develop and deploy digital technologies, better serving our teams, physicians, and ultimately patients. Evinova represents a unique opportunity to deliver meaningful outcomes with digital and AI to serve the wider healthcare community and create new standards for the sector.

Come and join our journey!

Are you a passionate Scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the opportunity to further exploit our drug discovery platforms? If yes, we have just the position for you at AstraZeneca, Discovery Sciences in Gothenburg, Sweden!


We are currently recruiting a motivated Senior Research Scientist with recognized oligonucleotide solid support synthesis expertise to join our Oligonucleotide and Targeted Delivery Chemistry team within the Oligonucleotide Discovery Department, part of the Discovery Sciences R&D organization at AstraZeneca in Gothenburg, Sweden.

This is an opportunity for you to apply your expert synthetic organic chemistry knowledge to expand the use of oligonucleotides, and molecular conjugates thereof, in the treatment of diseases across therapy areas within AstraZeneca. In doing so you demonstrate a passion for driving scientific questions, combined with strong working ethics and the ability to work well within teams aiming to drive drug discovery projects forward.

The Oligonucleotide and Targeted Delivery Chemistry team is working in close collaboration with other Scientists in Discovery Sciences, Medicinal Chemistry, Pharmacology, DMPK, Safety and Pharmaceutical sciences with a focus on the goal to design and develop the oligonucleotide therapeutics of the future. We offer a highly rewarding scientific environment, with the expectation to publish new findings.



What you will do
This role is a synthesis specialist role with a focus on developing oligonucleotide drugs and thereby supporting the AstraZeneca pipeline. You will also synthesize and purify high quality building blocks and compounds by applying cutting-edge technologies and methodologies to support project progression from pre-TSID to CDID according to agreed timelines, as well as applying purification and analytical sciences, troubleshoot challenges and make a significant contribution to the practical delivery of project compounds. You will work alongside other chemists in the team to support project priorities but should also be comfortable in supervising more junior colleagues. The role also includes development of new building blocks and linkers as well as setting up new techniques.

As a Senior Research Scientist you will propose experimental strategies and have the possibility to be creative in solving a wide range of synthetic challenges. You will plan, prioritize and perform your own work and actively collaborate with the project team by driving problem solving using literature and own knowledge. An important responsibility is to support oligonucleotide projects to ensure high scientific standards and quality of compounds to meet project objectives. You will build strong collaborative relationships within the team and in projects to ensure the smooth running of projects.




Essential for this role

*

PhD in Organic Chemistry; post-doc is a plus.
*

Expertise in oligonucleotide chemistry and oligo building blocks synthesis. Knowledge in the area of oligonucleotide therapeutics, design and data analysis is a plus.
*

Ability to design and execute experiments autonomously.
*

Evidence of experimental impact by either peer-reviewed publications or external presentations.



The successful candidate will demonstrate a passion for driving scientific questions and is a scientifically critical individual capable of receiving and analysing input from multiple fields and deciding on focused course of action. You should also be able to work independently and have a positive, result-oriented, and problem-solving attitude. Excellent English is required, both spoken and written, and ability to operate effectively in a multi-disciplinary research environment. We also believe that you enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.


Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's strategic science centres. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to develop a working environment that furthers collaboration, openness, and innovation. Therefore, we have built space for meetings, and socializing, where spontaneous meetings can give birth to new innovations.



Does this sound like your next challenge and a good workplace for you? Welcome to apply today!

We look forward to your application, but no later than August 25, 2024.

Would you like to utilise your planning and supply chain knowledge to lead clinical supplies for your portfolio of global clinical studies? With constant new products and launches, there has never been a better time to join Global Clinical Supply Chain and shape our future with a significant contribution to life-changing medicines.
We have an exciting opportunity for talented Supply Chain Managers to join our Clinical Study Supply Chain team in Gothenburg, Sweden. This is a key role within our Clinical Manufacturing and Supply teams, and we make sure clinical trial medications are available at the right quality, in the right quantity at the right time for every patient taking part in AstraZeneca's trials all over the world. Our goal is to never miss a patient.

In Pharmaceutical Technology and Development (PT&D) we are the bridge which turns forward-thinking science into actual medicines that help millions of people around the world. We work across the entire value chain, crafting and delivering active ingredients, formulations and devices required to support new medicines - from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

What you'll do

In this role you will project manage the design, plan, and set-up of the study supply chain to ensure on time delivery of clinical supplies. You will also lead the Study Drug Working Group and contribute to the Supply Chain Team Meetings enabling continuous cross-functional dialogue with both internal and external partners on study design requirements and associated changes which may impact the supply chain elements of the study.

Your accountabilities will include:


* Project manage the delivery of clinical supplies effectively and consistently, and input to the balance of costs and any risks to supply.
* Ensure effective communication with project teams and key partners across a global network.
* Support risk management of individual studies with proactive mitigation of risks that potentially impact the quality or delivery of supplies.
* Take ownership for Inventory management including any rework and recalls, extensions of shelf life and expiry date management, or stock destruction.
* Manage the Interactive Response Technology (IRT) system to execute demand and supply planning.
* Work within GMP Quality Management Systems ensuring that you actively handle any deviations, complaints and change controls.

Essential for the role

* Bachelor's Degree in a scientific or business subject area - equivalent experience will be considered
* Experience within a supply chain environment and/or pharmaceutical industry
* Holistic knowledge of end-to-end supply chain activities
* Experience in running projects and in?uencing customer demands
* Strong in?uencing, negotiating and problem-solving skills, across geographical and cultural boundaries
* Excellent English written and verbal communication skills
* Proficient IT skills with an ability to adapt and operate in bespoke multiple systems

Desirable for the role

* Awareness of GMP (Good Manufacturing Practise) and GCP (Good Clinical Practice)
* Experience of demand planning and forecasting as well as risk identification and management
* Knowledge of clinical development processes relevant to the supply of clinical materials
* Lean knowledge and understanding
* Experienced in handling Quality Events (Deviations, Change Controls, Complaints)

Why AstraZeneca?

Join our multigenerational team to experience our inclusive and encouraging culture. We believe in shared success, a place where ideas are welcomed and awarded. Be comfortable speaking up, taking responsibility for your actions and working together to succeed.
Our stunning campus in Gothenburg is one of AstraZeneca's three strategic science centres. The site is home to over 2,500 employees, from 70 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally.

Welcome with your application no later than August 23rd, 2024.

Are you an experienced scientist with expertise in pharmacokinetics, pharmacology and drug metabolism (DMPK)? Would you like to apply your expertise in a global company that follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!

Our team is growing, and we are now looking for a motivated individual with experience in Biologics and/or small molecule drug development and PKPD, to join us as a DMPK Project Leader, from candidate selection to registration and beyond. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress.

This position will be on-site at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, and will not have the ability to be located remotely.

Respiratory & Immunology (R&I) is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function, with research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management.

What you'll do?
With a true passion for drug discovery you will support our portfolio within the R&I therapeutic area as a subject matter expert. In the DMPK project lead role you will work collaboratively with project representatives from other disciplines. These may include biology, safety , clinical pharmacology, pharmaceutical sciences, antibody Discovery/Protein Engineering and medicinal chemistry, where your task is to influence candidate profiling by providing the necessary DMPK support for clinical investigations.

It is your responsibility to ensure delivery of all DMPK related activities throughout the value chain in accordance with regulatory requirements. These include preclinical PK experiments, in vitro ADME and biotransformation to yield pharmacokinetic understanding. Furthermore, assisting design of pharmacodynamic studies that ultimately delivers a pharmacological assessment underpinning human dose prediction and emerging clinical experience.

You will work as the development DMPK representative on project teams from candidate selection to registration and beyond. We believe that you have a solid understanding of DMPK, a working knowledge of pharmacology, and that you will be able to provide expert advice and interpretation of complex nonclinical and clinical data.

Main duties and responsibilities;

*

Communicate scientific progresses both externally and internally
*

Deliver DMPK input and data to projects within agreed timelines and to the right quality
*

Responsible for delivering and produce the nonclinical pharmacokinetic documentation to support clinical progression
*

Apply an understanding of DMPK to support/influence compound profiling, project progression and project strategy
*

Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
*

Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
*

Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities
*

Prepare clear presentations related to the above for internal governance bodies



Your level of professional experience will be relevant for your initial career level (Senior Scientist, Associate Principal Scientist or Principal Scientist).



?Essential for the role

*

PhD or equivalent experience in a relevant field
*

Expert in DMPK sciences with profound knowledge of drug discovery and development processes
*

Broad experience in biologics drug development (PK & Bioanalysis)
*

Have PK modelling skills, experience of human PK and dose prediction, as well as an understanding of disease biology and PKPD
*

Experience with regulatory submissions for biologics and/or small molecules
*

Knowledge of all DMPK assays including the use of in silico tools for PK prediction
*

Experience in project leadership
*

Collaborative mindset and a team player
*

Proactive in providing expert support to project team and excellent communication skills


Work policy
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until August 31, 2024. For more information about the position, please contact recruiting manager Lassina Badolo at Lassina.Badolo@astrazeneca.com

Note: Due to the summer vacation period in Sweden, the screening process may take a bit longer than usual. Please bear with us, and we will get back to you as soon as possible when we are back mid/end of August.?

Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Evinova is a new innovative health-tech business with the ambition to deliver industry-leading digital health solutions to the wider healthcare community, to improve patient experience and outcomes. It is an independent company, part of the AstraZeneca group.

The Product Manager will lead our work to design and develop a state-of-the-art platform for deployment of patient and site facing technologies in clinical trials for Evinova customers. The role will work with other SMEs within and outside Evinova to deliver innovative approaches to transform the user experience, deploy products and support the onboarding of new studies in an efficient way securing the highest quality and speed. You will also be responsible for mapping the external technical landscape and understand similar products pro's and con's from a patient/HCP/Sponsor perspective. You will work in a team of Product Managers/Owners to jointly deliver a flexible product that covers most aspects of patient and site staff interactions in a clinical trial.

The Product Manager will focus on solutions for biosample management to reduce burden on site while improving quality in information collected. This includes, but is not limited to, tracking status from point of collection to analysis and integration with other key system in this value flow.

Responsibilities:

You will:

* Lead work to design and deliver the required solutions for management of biosamples at the site to deliver a transformed experience for site staff while improving the information flow.
* Engage with SMEs to identify end user, sponsor or regulatory needs for an optimal management of biosamples.
* Work closely with the other Product Managers/Owners within Unified Trials as well as other products in Evinova.
* Work as part of a cross-functional agile delivery team in building and executing an implementation plan. Responsible for stimulating conceptual thinking and creativity and challenging the status quo for continuous improvement.
* You will need a deep understanding of business needs and users' needs to craft the processes, solution and prioritise improvement needs.
* Deliver high-quality, hypothesis tested, business requirements, functional specifications, business processes, and system rules.
* Understand the current landscape of similar technical solutions and what their strengths and development areas are.
* Deliver effective recommendations for prioritisation regarding the product backlog items in order to deliver maximum outcome with minimum input in line with business priorities.
* Review, analyse and evaluate business systems/processes and user-needs while serving as the key link between digital and IT development teams.
* Act as a change agent during the global roll-out of new technologies - embed new tools and technologies into the business and measure success. Provide leadership for those leading the day-to-day implementation of new tools through to completion.
* Help build a learning organisation: ensure that any learning associated with the programs is shared within the Evinova.

Essential Requirements:

* 3 or more years experience with management of biosamples or related areas
* 3 or more years of Product Management/Owner experience, preferably with larger complex solutions in clinical research.
* Knowledge about Clinical trial delivery and Pharmaceutical drug development
* Awareness of GCP, 21 CFR part 11, relevant guidelines from ISPOR, ISOQOL, FDA, EMA
* Proven ability to work collaboratively in a cross functional setting with internal as well as external partners
* Proven ability to challenge the status quo, take ownership and holds self and others accountable
* Senior Stakeholder management skill with together with proven negotiation, collaboration and interpersonal leadership skills
* Effective problem and conflict solving skills
* Excellent written and verbal communication skills, with the ability to deal with ambiguity and create clarity
* Passion for Customers, representing the needs of multiple customers in decision making.

Desirable:

* Knowledge about the Clinical Research eco-system and key solutions like Labsystems, EDC, etc.
* Thrives in a fast-paced work environment, comfortable with complexity and uncertainty at times, lots of humour, dedication to deliver outcomes and motivated by the opportunity to rethink our approach to healthcare.
* Comfort and skills operating in a heavily matrixed organizations with excellent skills and intuition to manage the needs of various partners.
* Ability to rapidly grasp concepts and excellent ability to handle complexity by simplifying it and providing clear directions to the team
* Ability to manage and influence strategically and persuade tactfully, to acquire desired outcomes while maintaining effective, positive, organizational relationships

* Comprehensive understanding of dynamics affecting the pharmaceutical industry and needs for transformation

* Ability to work globally including international travel

Join us on our journey of building a new kind of health tech business to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting-edge methods, and bringing unexpected teams together. Interested? Come and join our journey.

Are you a curious Scientist who wants to join a team working with outstanding science that have a direct impact for patients? Do you also want to contribute to our larger purpose with great colleagues by your side working in a collaborative, global environment? If yes, welcome to join AstraZeneca!



We are now looking for a Translational Scientist to join our Precision Medicine Discovery and Development team. This role is based at our site in Gothenburg, Sweden.

The Early Respiratory and Immunology (Early R&I) Translational Science and Experimental Medicine (TSEM) department is a fast-paced environment, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population, and to close the gap between bench science and bedside clinical practice.



A key role of Precision Medicine Discovery and Development is to lead the development of precision medicine in immunological and respiratory diseases, driving patient stratification and delivering translational clinical validation, underpinned by the understanding of disease relevant pathways and drivers.



What you'll do?
The Translational Scientist is accountable as member of the Translational Science team for the development and optimisation of molecular biology techniques and biomarker assays to enable precision medicine and target validation strategies. Continuous collaboration with Translational Science Leads, Bioscience, and Biomarker Discovery colleagues will be essential to qualify relevant experimental techniques, disease models and biomarkers according to projects requirements. This is a laboratory role, requiring flexibility to ensure all experimental aspects of the projects are supported according to timelines.



This is a key scientific laboratory role, where you will be focusing on:



* Enabling precision medicine strategies to select the patients most likely to benefit from our medicines by developing biomarker assays and analysing biomarkers in experimental medicine cohorts
* Building mechanistic understanding of targets and diseases through setting up and execution of novel molecular biology techniques
* Establishing and using advanced human disease models to deliver human target validation data and early target engagement assessments
* Identifying Proof of Mechanism (PoM) biomarkers to demonstrate target engagement in clinical studies

Essential for the role:
* Bachelor's degree with a strong experimental drive and background in relevant scientific field
* Experience in a pharmaceutical or biotechnology industry setting
* Broad understanding of relevant technologies and methodologies along with excellent laboratory skills and ability to experimentally address key scientific questions
* Experience in setting up novel molecular biology techniques
* Experience in working with human biological samples
* Understanding of the Immunology and/ or Respiratory therapy area and disease biology, including related molecular pathways and mechanisms
* Skilled in hypothesis forming and testing
* Skilled in data analysis, interpretation and archiving
* Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects
* Proven written, oral, presentation and interpersonal skills



Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we're proud to have an outstanding workplace culture that encourages innovation, entrepreneurship, and collaboration through scientific research. Employees are empowered to express diverse perspectives and are made to feel valued, energised and rewarded for their ideas and creativity.



What's next?
If you are ready to make a difference - apply today, and we'll make it happen together!

Are you an experienced Senior Scientist with a background in cell biology and assay development? Do you like innovative approaches and do you have a passion about the possibilities of science to change lives? Perfect, this position might be your next challenge at AstraZeneca!

We are looking for a motivated and engaged Senior Scientist to join our Oligo Cell Assay Development team at AstraZeneca in Gothenburg. As a Senior Scientist in oligo cellular assay development, you will use your knowledge of cells and assay technologies to develop state-of-the-art cell-based assays for screening and profiling of potential therapeutic oligos such as antisense oligonucleotides or siRNA, with the aim to identify lead molecules. You will contribute to the progression of drug projects by bringing novel ideas and scientific strategy. You will work within Discovery Sciences, part of AstraZeneca's BioPharmaceuticals organisation, with a focus on scientific advances in drug discovery across therapeutic areas including, respiratory and inflammation (R&I), cardiovascular, renal and metabolism (CVRM) and rare disease (Alexion).



What you will do

This is an exciting opportunity for you to join us as a lab-based scientist to develop cell assays for discovery of novel oligonucleotide-based therapies. The assays you develop will be used in projects in all phases of AstraZeneca's drug discovery pipeline. You will work closely with our colleagues in the Cell engineering and Cell banking teams, screening scientists in the oligo profiling team, and the rest of the AstraZeneca therapeutic oligo platform.



We believe that our new colleague is a highly motivated scientist with a keen interest in technological and scientific advances. Along with this we see you as a person who enjoys collaboration, who holds networking skills with experience of interacting effectively across functions and disciplines. This goes hand in hand with your problem-solving skills, great goal focus and enthusiasm for science.



You will be strongly encouraged and supported to think creatively in our dynamic environment. Here, we are free from fear of failure, free to ask the right questions, and make bold decisions.

Essential for the role

*

PhD in Biology, Pharmacology, Cell biology or a related discipline or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry.
*

Highly skilled in cellular biology techniques applied to develop cell-based assays.
*

Extensive experience in the development and application of assays for quantitative measurements of RNA transcripts.
*

Experience with therapeutic oligonucleotides (e.g. ASOs or siRNAs).
*

Experienced in working with many and diverse cell models.
*

First-rate analysis and decision-making skills, coupled with a tenacity to see decisions through, even in situations of ambiguity.



Desirable for the role

*

Expertise in a range of cell biology techniques, including cloning, transfection methods, and gene expression knock-down (RNAi or other).
*

Experience in the design, development and validation of cellular assays for compound screening and /or profiling.
*

Cellular imaging and image analysis experience.
*

Experience with automation for cell assays.



Why AstraZeneca?
Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. This is the place to go beyond discovery - we think holistically about patients and are always learning from those living with diseases.

So, what's next? If this sounds like the role and place for you - welcome to apply today!

Send your application as soon as possible, but no later than August 11, 2024.

For further details around this position you are welcome to contact the recruiting manager Karl-Johan Leuchowius, karl-johan.leuchowius@astrazeneca.com

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Make a move to Global Gothenburg: https://www.youtube.com/watch?v=c-Iqbb4aw38
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

We are looking for an experienced bioinformatician to join our Data Science & Bioinformatics team. You will be part of the Translational Science and Experimental Medicine (TSEM) department in the Respiratory and Immunology therapeutic area. As a department we promote an open and collaborative atmosphere, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective targets and the right patient populations.

This role is located at one of our sites in either Gothenburg (Sweden) or Gaithersburg (US).

Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions. We harness data science & AI to fast-forward our research. Making sure work born in a lab can make a real difference, every day, impacting patients' lives across the world.

What you will do
In this role, you will work in a highly cross-functional and thriving environment together with specialists in sequencing, immunological and respiratory disease, as well as with other data science & bioinformatics experts.

For this role we are looking for an outstanding bioinformatician to enable translational science via integration of large-scale omics, clinical data, real world evidence and literature data to deliver precision medicine within our pipeline. You´ll be identifying novel targets, biomarkers and patient sub-groups through innovative data analysis approaches including utilization of clinical cohort omics data sets.

You will contribute to the identification of transformational precision medicine propositions to deliver life changing medicines to patients. You will be responsible for planning, performing and interpreting your analysis and communicate results. By applying state-of-the-art analytical methods, you will maximise the knowledge extrapolated from our growing omics data in complex diseases impacting the project progression and future treatment options for patients with unmet medical needs.

Depending on your previous experience, your initial career level will be an Associate Principal Scientist or Senior Scientist.

Essential for the role

* MSc with extensive industry experience (4+ years), or preferably, PhD or equivalent in bioinformatics, data science, statistics, biostatistics, mathematics, or another similar subject area.
* Substantial experience and proficiency in large-scale omics data analysis, integration and interpretation is a requirement. Omics include transcriptomics, single cell, spatial transcriptomics, proteomics (Olink, LC/MS), genomics, and other types of next generation sequencing (NGS) such as chromatin state approaches.
* Excellent coding skills in Python, R, or similar language appropriate for large scale omics analysis and experience with version control (Git/Bitbucket).
* A good understanding of life sciences and how omics data can be utilised to derive biological insight is required. Experience from applying this across different phases of pharmaceutical discovery and development is a preference.
* Outstanding communication and collaboration skills, both with experts and non-experts, and with peers as well as stakeholders is expected. Our team is a collaborative group, so the ability to be comfortable working in a goal-oriented way, with a team focused approach is central to be successful in the role.
* We believe you also have a high degree of independence and a proactive and delivery focused approach.

Desirable for the role

* Experience in pharmaceutical R&D and/or Post-doc experience.
* Molecular understanding of human diseases, patient stratification and biomarker-based endpoint generation, preferentially in respiratory and immunological disorders.
* Understanding of in vitro and in vivo model systems and assessment of translatability.
* Track record of applying bioinformatic analysis to drive projects in drug discovery or development in an industrial or academic setting. Familiarity with network analysis.
* Broad experience applying machine learning methods such as random forests, clustering, dimensionality reduction in a systems biology or systems medicine context.

* Working in a Linux environment, ideally with experience of cluster or cloud computing (e.g. AWS or Azure).
* Experience from leading projects with internal groups/external collaborators.

* Experience working within cross-functional teams.

Work policy
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

What's next?
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application (including CV and cover letter), no later than July 24, 2024. If you're curious to know more about the position, please get in touch with hiring manager Greet De Baets at greet.debaets1@astrazeneca.com.

Where can I find out more?
Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/
Follow AstraZeneca on Instagram: https://www.instagram.com/astrazeneca_careers/?hl=en
Read more about BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

AstraZeneca is a global, science-led biopharmaceutical business whose innovative medicines are used by millions of patients worldwide. We are committed to making a meaningful difference to patient health through great medicines that bring benefit for patients and add value for our stakeholders and society.



We are seeking an experienced Automation Software Engineer / Application Specialist to join our multidisciplinary Chemistry Automation team at the AstraZeneca site in Gothenburg, Sweden. With your expertise and skills, you will play a vital role in advancing our automated compound synthesis platform. The ideal candidate will have a strong background in working with hard- and/or software of laboratory automation technologies used in pharmaceutical research, a good understanding of the scientific disciplines needed in drug discovery and a proven record of successfully implementing, operating, and troubleshooting automation software.



What you will do

You will join and support the Chemistry Automation team (iLAB) within the Compound Synthesis & Management department which overall is focusing on making and processing chemical compounds using innovative science and technology that accelerates the discovery of novel medicines to impact patients' lives. The department has no less ambition than to be a pioneer and industry leader in the application of laboratory automation technologies for both the synthesis of chemical compounds and their subsequent processing into the drug discovery workflow. In this team you will be able to use your experience and skills to ensure that Chemistry Automation in combination with AI will contribute significantly to the aimed accelerated discovery of novel medicines.



Key responsibilities:

*

Collaborate in a multidisciplinary team of synthetic and analytical chemists, automation engineers, and software developers, to create a world-leading autonomous chemical synthesis laboratory.
*

Work with automation workcell software and equipment to design and implement complex device integrations, as well as troubleshoot and optimize existing automation protocols in chemical drug discovery.
*

Evaluate and carry out critical analysis of new software and other tools or technologies, to improve the quality and efficiency of automated laboratory processes.
*

Travel to external partners to participate in regular update meetings and factory acceptance tests.



Required qualifications

*

Degree in a science or engineering field with minimum of 3 years of experience in developing software for automated laboratories in a life sciences field.

*

Highly proficient in C# or other programming languages and frameworks (e.g .NET, Python, Java etc.)
*

Experience of integrating software with laboratory instruments, robots, or automation workcells.
*

Excellent communication skills to be able to both convey complex technical descripts to non-experts and understand vice-versa.



Beneficial qualifications

*

Knowledge of object-oriented programming; software architecture and design patterns, including cloud-based platforms.
*

Experience with programming standards or paradigms such as RestFUL APIs, SOAP, OPC UA, JSON, XML, etc.
*

Experience with scheduling, orchestrator, or LIMS software (e.g., HighRes Cellario, Biosero Green Button Go, Titian Mosaic, Thermo Fisher SampleManager, etc.).
*

Knowledge of the pharmaceutical industry and drug discovery process.



Why AstraZeneca?
Join the team unlocking the power of what science can do. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we can grow our pipeline and positively impact the lives of billions of patients worldwide. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.


So, what is next? If this sounds like the job and place for you - apply today!

You are welcome with your application but send it to us no later than August 8, 2024.

For more information about the position please contact Dr Michael Kossenjans, Director Chemistry and Head of AZ Chemistry Automation at michael.kossenjans@astrazeneca.com.

Additional information
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

Introduction to role:

Are you ready to make a significant contribution to life-changing medicines? We are looking for a capable Supply Chain Managers to join our Clinical Study Supply Chain team in Gothenburg, Sweden. This is a key role within our Clinical Manufacturing and Supply teams, ensuring clinical trial medications are available at the right quality, in the right quantity at the right time for every patient taking part in AstraZeneca's trials all over the world. Our goal is to never miss a patient!



Accountabilities:

In this role, you will project manage the design, plan, and set-up of the study supply chain to ensure on time delivery of clinical supplies effectively and consistently. You will lead a cross-functional team enabling continuous dialogue with both internal and external partners on study design requirements and associated changes which may impact the supply chain elements of the study.



Your main responsibilities will include supporting and balancing cost and risk management of individual studies, and proactively mitigate any risks related to the delivery or quality of supplies. This includes taking ownership for inventory management including any rework and recalls, extensions of shelf life and expiry date management, or stock destruction. You will work within GMP Quality Management Systems ensuring that you actively handle any deviations, complaints and change controls. It is important to ensure effective communication with project teams and key partners across a global network. You will manage the Interactive Response Technology (IRT) system to complete demand and supply planning.



Essential Skills/Experience:

* Bachelor's Degree in a scientific or business subject area - equivalent experience will be considered
* Experience within a supply chain management environment with a complete knowledge of end-to-end supply chain activities
* Experience of demand planning and forecasting and risk identification and management
* Experience in running projects and influencing customer demands
* Strong influencing, negotiating and problem-solving skills, across geographical and cultural boundaries
* Excellent English written and verbal communication skills
* Proficient IT skills with an ability to adapt and operate in multiple custom systems



Desirable:

* Awareness of GMP (Good Manufacturing Practise) and GCP (Good Clinical Practice)
* Knowledge of clinical development processes relevant to the supply of clinical materials
* Lean knowledge and understanding
* Experienced in handling Quality Events (Deviations, Change Controls, Complaints)



When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.



At AstraZeneca, we are driven by the desire to make a significant impact on patients' lives. We are at an exciting time of new products and launches, working with innovative and scientific products on our leading-edge end-to-end supply chain. We foster an encouraging, positive environment where ideas are welcomed and rewarded. As part of our agile team, you'll have the opportunity to contribute as we problem-solve to progress together. If you are driven, take smart risks and are able to act quickly, then this is the place for you.



Ready to make your mark? Apply no later than July 17th, 2024 and join us in our mission to deliver life-changing medicines!

Join us as a Product Engineer, a role that sits at the intersection of design and development. As an experienced individual contributor, you will provide technical leadership in projects and pair with product managers and design leads in the early stages of development.

We are looking for a creative and experienced Full Stack Engineer to join our team, focusing primarily on the early phases of product delivery such as design and prove phases. In this role, you will play a critical part in shaping the development of our products from conception to initial implementation, using your technical expertise and product mindset to drive successful outcomes. The role combines in-depth understanding of people, a mindset for curiosity and experimentation, with a passion for building innovative technology solutions.

What you'll do:
As a Product Engineer, you will drive the engineering effort in a highly dynamic environment, initially in a small team comprised of yourself, a product researcher/designer, a product manager, and business stakeholders. Your role will be to bring ideas to life by building conceptual prototypes quickly. You will also drive the development of prototypes, proof of concepts, and minimum viable products (MVPs) to validate product ideas and gather user feedback before making decisions to scale.


Essential Skills/Experience:

*

7+ years of working experience, preferably at the intersection of Life Science and software engineering.
*

Bachelor's degree in Engineering, Computer Science, or a related field.
*

Proven experience in full stack software engineering, with a focus on early-stage product development and delivery.
*

In-depth knowledge of cloud platforms (e.g., AWS, Azure, GCP) and modern DevOps practices.
*

Proficiency in programming languages such as Java, Python, JavaScript, or other relevant languages.
*

Proficiency in using no-code tools for rapid prototyping.
*

Demonstrated ability to translate product requirements into technical specifications and architect scalable, maintainable software systems.
*

Strong understanding of agile methodologies and experience working in cross-functional, collaborative environments.
*

Excellent problem-solving skills and a creative mindset for exploring innovative solutions to technical and product challenges.
*

Effective communication skills, with the ability to articulate complex technical concepts to non-technical stakeholders.
*

A passion for continuous learning and staying abreast of new technologies, tools, and industry best practices.
*

Fully proficient in all aspects of DevOps (source control, continuous integration, deployments, etc.) and Experience with CI/CD tools (Ansible, Jenkins, Sonar Qube, Artifactory, Docker, GitHub, Jenkins, Kubernetes, Maven etc)

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?
At AstraZeneca's and in R&D IT, you'll be working with ground-breaking technology. This marriage between our purposeful work and the use of high-tech platforms is what sets us apart. Help shape and define the products of the future; with the backing you need from across the business.

Our work has a direct impact on patients, transforming our ability to develop life-changing medicines. We empower the business to perform at its peak and lead a new way of working, combining ground breaking science with leading digital technology platforms and data. All with a passion to impact lives through technology, data, analytics, AI, machine learning and more.

Join us at a crucial stage of our journey in becoming a digital and data-led enterprise. Make the impossible possible by building partnerships and ecosystems, creating new ways of working and driving scale and speed to deliver exponential growth.

Ready to disrupt an industry and change lives? Apply now!

We welcome your application no later than June 25th.

AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines. Our purpose is to push the boundaries of science to deliver life-changing medicines. Pharmaceutical Technology & Development (PT&D) at AstraZeneca is at the heart of our mission to create innovative and reliable pharmaceuticals.

PT&D is the organization that turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices for new medicines and providing expert technical support to all AstraZeneca's commercial drug substances and products to ensure we successfully supply medicines to patients.

We are now seeking highly qualified, forward-looking Associate Principal Data Scientists to lead initiatives within our global Digital Science team!

Job Description

The successful candidate will have a strong background in machine learning (ML) and AI, including neural networks and deep learning. Experience with natural language processing (NLP) and language models including large language models (LLMs) is of particular interest You will be responsible for developing cutting-edge algorithms and models that will transform the drug development process, strengthening the quality of our science and drive significant operational efficiency.

Key Responsibilities

* Partner with global customers across PT&D to identify opportunities and lead the development and implementation of advanced ML and AI models, with a focus on applications of NLP and language models.
* Innovate and implement state-of-the-art neural network architectures for a variety of complex tasks in pharmaceutical drug development.
* Lead the evaluation and incorporation of the latest ML and AI research into practical applications to advance AstraZeneca's objectives.
* Drive cross-functional collaboration with data scientists and engineers as well as domain experts to ensure successful integration, scaling and deployment of ML and AI solutions across the organization.
* Act as an inspiring leader and mentor for junior colleagues, providing guidance and fostering technical growth.
* Articulate and present complex data-driven insights and their business implications to senior management and other key collaborators.
* Ensure the integrity and confidentiality of all data and models in compliance with company policies and regulations.

Essential qualifications and skills

* MSc or PhD or equivalent experience in Computer Science, Data Science, Computational Linguistics or a related quantitative field.
* Significant experience in ML and AI, and in particular NLP and language models, with a portfolio of successful projects.
* Advanced programming skills in Python, R, or similar languages, and extensive experience with machine learning frameworks such as PyTorch or TensorFlow.
* Proven track record of handling large datasets and leverage cloud computing platforms (e.g., AWS, GCP, and Azure) for complex data science tasks.
* Exceptional problem-solving capabilities and the capacity to lead high-level projects with minimal supervision.
* Outstanding communication skills, with the ability to influence and engage directly with a diverse range of senior partners.

Preferred qualifications and skills

* Demonstrated experience in applying ML and AI and specifically NLP and LLMs to solve problems in the pharmaceutical or related fields.
* Familiarity with state-of-the-art technologies such as physics-informed neural networks, liquid neural networks, and neural differential equations, and their potential impact on drug discovery and development.
* A commitment to best practices in data management and a track record in fostering reproducibility and transparency in research.
* A strong publication record in their field of expertise.

Why AstraZeneca?

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.

We welcome your application (CV and cover letter) no later than 27th June 2024

Competitive Benefits & Salary

Opening date: 13th June 2024

Closing Date: 27th June 2024

Are you ready to be part of the future of healthcare? Can you think big, be bold, and harness the power of digital and AI to tackle longstanding life sciences challenges? Then Evinova, a new health tech business part of the AstraZeneca Group might be for you!

Transform billions of patients' lives through technology, data, and cutting-edge ways of working. You're disruptive, decisive, and transformative. Someone excited to use technology to improve patients' health. We're building a new Health-tech business - Evinova, a fully-owned subsidiary of AstraZeneca Group. Evinova delivers market-leading digital health solutions that are science-based, evidence-led, and human experience-driven. Thoughtful risks and quick decisions come together to accelerate innovation across the life sciences sector. Be part of a diverse team that pushes the boundaries of science by digitally empowering a deeper understanding of the patients we're helping. Launch pioneering digital solutions that improve the patients' experience and deliver better health outcomes. Together, we have the opportunity to combine deep scientific expertise with digital and artificial intelligence to serve the wider healthcare community and create new standards across the sector.

The Product Engineering organization consists of several self-organized/managed cross-functional teams with the people and skills needed to deliver our innovative digital products and solutions to patients and healthcare providers participating in clinical trials around the world. We are working with agile methodology delivering a new release of the software product with program increments every quarter.

We are proud to have one of the best software development teams you can find with deep technical and business skills to shape the product from early ideas and requirements through full implementation and support. This is a place where you can grow and learn together with other people delivering software with a great purpose.

About the Role
In this role you will be joining a team that develops a frontend application (mobile & web) as well as a backend-for-frontend layer in NodeJS. The team is part of a larger programme containing a web portal, mobile apps, medical devices integrations, content management system, app configurations and many more integrations. You will be part of a digital product development and engineering organization that consists of many cross-functional and self-organized/managed teams having the people, skills, and resources to deliver their part of the product. We work closely with health professionals and patients throughout the company with many separate roles. We are a global company who believe in our people, as our people make the difference. We honor diversity and collaboration.

Key responsibilities include:

* Develop new frontend functionality for patient facing web and mobile applications.
* Develop functionality in a backend for frontend layer as well as a configuration layer in nodeJS.
* Mentor other developers in team
* Elaborate features with BA, PO and stakeholders.
* Participate in scrum activities and PI planning.
* Support test and incident handling teams with investigation and / or bugfixes.

Minimum Qualifications:

* Msc in computer science / information technology / engineering
* More than 7 years of Software development experience
* More than 3 years of Lead developer experience
* Frontend development (React) in larger projects
* Version control in Git
* Unit testing like jest
* Typescript
* NodeJS
* GraphQL
* Test driven development (TDD)

Desired Qualifications:

* Web / Mobile Accessibility
* Basic CI/CD in eg Azure Devops
* React Native or native iOS / Android
* Design / Figma collaboration
* Design systems
* Backend development (Java)


When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why Evinova (AstraZeneca)?
Evinova draws on AstraZeneca's deep experience developing novel therapeutics, informed by insights from thousands of patients and clinical researchers. Together, we can accelerate the delivery of life-changing medicines, improve the design and delivery of clinical trials for better patient experiences and outcomes, and think more holistically about patient care before, during, and after treatment. We know that regulators, healthcare professionals, and care teams at clinical trial sites do not want a fragmented approach. They do not want a future where every pharmaceutical company provides its own, different digital solutions. They want solutions that work across the sector, simplify their workload, and benefit patients broadly. By bringing our solutions to the wider healthcare community, we can help build more unified approaches to how we all develop and deploy digital technologies, better serving our teams, physicians, and ultimately patients. Evinova represents a unique opportunity to deliver meaningful outcomes with digital and AI to serve the wider healthcare community and create new standards for the sector.

Join us on our journey of building a new kind of health tech business to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting-edge methods, and bringing unexpected teams together. Interested? Come and join our journey!

Are you an expert at reducing cyber risk in a large, global enterprise? Are you a technical problem solver? If so, then you might be the next colleague to join our Cyber security team at AstraZeneca in Gothenburg, Sweden!

Join AstraZeneca, a global, innovation-driven Biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. We are more than one of the world's leading pharmaceutical companies. We are a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit.

As our Cyber Security Associate Director, you will lead, develop and maintain cyber security risk reduction initiatives embedded within each IT Business Technology Group, and in designated country businesses. This role is crucial in aligning the global Security Policy Framework to IT business functions.

Accountabilities:

In this role, you will develop and implement security policies, procedures, and operating practices. You will coordinate risk profile development and distribution to IT business facing audiences and maintain compliance with all AstraZeneca Security Policy Framework requirements. You will support cyber risk assessments and make recommendations to IT business facing leadership. You will also help mature the AstraZeneca Cyber Security and Awareness education program and ensure appropriate training for all employees and contractors.

Essential Skills/Experience:

* A relevant technical degree, competence or equivalent (CISSP, CISM, CCSP) and competence to lead various Security initiatives

* Extensive experience working in Security, in a complex, multinational, corporate environment

* Deep understanding of information security technologies, networking and network architecture required.

* A global perspective on privacy, security, and data protection issues and trends

* Excellent problem solving and troubleshooting skills, autonomous working, direction and goal setting

* Experienced in developing and leading innovative solutions and "thinking outside of the box"

* Ability to analyze and communicate complex situations, assessing risks and balancing strategic and tactical Security requirements with business pragmatism, risk appetite and innovation

* Knowledge of third party risk management approach to business facing specific vendor partnerships.

* Experience working in a global organization where partners and team members are geographically dispersed.



Desirable Skills/Experience:

* -Experience with cyber security assessments and penetration tests.

* -Experience of working in other IT disciplines and across a range of industries and sectors.



Ready to make a difference? Apply now but no later than June 10 and join us in our journey to discover the next life-changing medicine!



About AstraZeneca

At AstraZeneca, we dare to lead. We apply our problem-solving mindset to identify and tackle opportunities across the whole enterprise. Our spirit of experimentation is lived every day through our events like hackathons. We enable AstraZeneca to perform at its peak by delivering world-class technology and data solutions. Our work unlocks the potential of science. We optimise and revolutionise AstraZeneca by maximising efficiencies and finding new ways to drive productivity. From automation to data simplification.