Göteborg: Analytical Scientist

About the position
We are now looking for a Scientist to join the In vivo Bioscience team within Research and Early Development, Respiratory & Immunology in Gothenburg, Sweden.

Respiratory & Immunology is one of AstraZeneca’s main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases. In this role, you will focus on mouse models of inflammatory bowel disease (IBD).

Responsibilities
As part of the team, you will plan, execute and analyse ex vivo samples generated from in vivo studies to progress our drug discovery projects and generate publishable scientific insights. You will actively take part in scientific discussions to add valuable inputs in experimental design and data interpretation.

This is a mainly lab-based role where you will be involved in ongoing projects focusing on pre-clinical experiments.

What you’ll do:

• As a Scientist you will be a vital member of the in vivo community and will contribute to the development and characterization of pre-clinical models of IBD to discover novel therapeutics.
• You will contribute to the analysis of in vivo studies with a specific focus on FACS analysis.

Your profile
• At last 5 years of experience with regular FACS analysis of mouse samples (organ processing and digestion, cell staining, antibody panel set up, proficient in the use of BD FACS DIVA machines and Flowjo).
• Ability to organize, execute and interpret the results from in vivo studies according to study plans in agreement with the team leader or other colleagues.
• Experience with other in vitro methodology in addition to FACS (ELISA/MSD and/or qRT-PCR) to analyze ex vivo samples generated from in vivo studies.
• Experience of maintaining the highest standards of welfare and ethical compliance and ensuring the integrity of the generated data. Familiar with using Good Statistical Practice in animal research and applying the 3R’s (reduction, refinement and replacement) across the full range of studies.
• Valid education required for compliance to work with live animals in Sweden.
• Excellent English written and oral communication skills, including presentation skills.

Desirable for the role:

• Degree in immunology (master or PHD) and understanding of autoimmune diseases with a specific focus on gut immunology.
• Several years of hands-on experience with rodents including live animal handling, drug administration through different routes (i.v, i.p., p.o.), blood and organ sampling and processing (colon, small intestine, spleen, lymph nodes).
• Experience with animal models of inflammatory bowel disease (IBD) and in vivo PK/PD relationships.

About the organisation
QRIOS Life Science can offer several opportunities for skilled people with a background in biochemistry, chemical engineering or science. We work with Sweden’s leading pharmaceutical and life science companies. So whether you’re interested in research, regulatory affairs, quality assurance, environmental and quality control, sales and marketing, or just want a career change, we have the job for you.

Working as a consultant suits whoever wants to get a lot of experience in a short period of time. We offer you the chance to work with well-known brands at renowned companies where you can develop your skills. If you’re looking for a world of exciting assignments and new contacts, you’ll like being a consultant.

About Astra Zeneca:
AstraZeneca is a major international healthcare company engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we are more than one of the world’s leading pharmaceutical companies - at AstraZeneca, we are proud to have a unique culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Do you have a passion for PKPD modelling of antibody-based therapeutics and expertise in respiratory and immunology? Would you like to apply your knowledge in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for!



We currently have an exciting opportunity for a passionate PKPD modelling and DMPK Scientist to join our DMPK department as a Biologics Translational PKPD Modeling & DMPK Specialist within Early Respiratory and Immunology (R&I). The R&I DMPK department provides drug metabolism and pharmacokinetic, as well as translational PKPD modeling & simulation support to our portfolio. This position is located at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.



At AstraZeneca Early Respiratory & Immunology (R&I), we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.



What you'll do?
As a Biologics Translational PKPD Modelling & DMPK Specialist (Principal Scientist) you will have the opportunity to drive strategy and provide global leadership in PKPD science across our diverse portfolio, and act as role model, mentoring and guiding less experienced members of the team. You have in-depth knowledge of biologics drug discovery and a keen interest in understanding the translational PKPD of antibody-based therapeutics.

In the role you would provide projects with specialist modeling input into exploring PK/PD/Efficacy in pre-clinical models and use them to guide an understanding of the dosing across different patient populations.



Main Duties and Responsibilities:

*

Be the key link between the leadership team and department in driving the translational PKPD strategy and leveraging modeling approaches in discovery projects towards human dose predictions
*

Drive and embed strategic direction by developing and implementing best practices in supporting projects and share insight across the department
*

Able to handle and balance the workload of multiple projects and efficiently manage your time and submit pragmatic solutions/strategies to ensure effective support of your projects
*

Represent early R&I DMPK in projects and providing overall scientific leadership for cross functional collaborations involving DMPK
*

Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP)
*

Ensuring that translational PKPD approaches are embedded at the heart of project strategy and used to support design of appropriate experiments that are aligned to the strategy underpinning human dose prediction and providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria
*

Identify, champion and develop new ideas
*

Offer a breadth of influence and impact across AstraZeneca DMPK
*

Leading scientific discipline networks and acting as a focus for debate within the AstraZeneca scientific community
*

Develop excellent working relations with key stakeholders within both DMPK and in the project teams, to ensure strategic alignment, strong cross discipline collaboration and communication.



Essential for the role

*

PhD (or equivalent industrial experience) in a relevant field e.g. pharmacokinetics, pharmacology, biopharmaceutics etc.
*

7 years of industry experience in Modeling & Simulation, ideally in preclinical/translational setting with a focus on biologics
*

In-depth knowledge of therapeutic antibody drug discovery (incl. complex biologics, cell therapies, ADCs) and a keen interest in understanding the translational PKPD of antibody based molecules
*

Experience of DMPK project facing role in pharmaceutical R&D with a variety of therapeutic antibody formats (e.g. mAbs, Fabs, bispecifics, ADCs etc).
*

Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost
*

Excellent interpersonal skills, and ability to work in cross-functional teams as well as strong scientific leadership skills
*

Experience in defining quantitative modeling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, peptides, proteins, antibodies)
*

Hands on experience of using specialist tools such as WinNonLin/Phoenix, MATLAB, R, Berkely Madonna or similar



Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.



What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until March 31, 2024.

For more information about the position, please contact recruiting manager Nina Lawrence at Nina.Lawrence@astrazeneca.com

About the position
We are now looking for a Scientist to join the In vivo Bioscience team within Research and Early Development, Respiratory & Immunology in Gothenburg, Sweden.

Respiratory & Immunology is one of AstraZeneca’s main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases. In this role, you will focus on mouse models of inflammatory bowel disease (IBD).

Responsibilities
As part of the team, you will plan, execute and analyse ex vivo samples generated from in vivo studies to progress our drug discovery projects and generate publishable scientific insights. You will actively take part in scientific discussions to add valuable inputs in experimental design and data interpretation.

This is a mainly lab-based role where you will be involved in ongoing projects focusing on pre-clinical experiments.

What you’ll do:

• As a Scientist you will be a vital member of the in vivo community and will contribute to the development and characterization of pre-clinical models of IBD to discover novel therapeutics.
• You will contribute to the analysis of in vivo studies with a specific focus on FACS analysis.

Your profile
• At last 5 years of experience with regular FACS analysis of mouse samples (organ processing and digestion, cell staining, antibody panel set up, proficient in the use of BD FACS DIVA machines and Flowjo).
• Ability to organize, execute and interpret the results from in vivo studies according to study plans in agreement with the team leader or other colleagues.
• Experience with other in vitro methodology in addition to FACS (ELISA/MSD and/or qRT-PCR) to analyze ex vivo samples generated from in vivo studies.
• Experience of maintaining the highest standards of welfare and ethical compliance and ensuring the integrity of the generated data. Familiar with using Good Statistical Practice in animal research and applying the 3R’s (reduction, refinement and replacement) across the full range of studies.
• Valid education required for compliance to work with live animals in Sweden.
• Excellent English written and oral communication skills, including presentation skills.

Desirable for the role:

• Degree in immunology (master or PHD) and understanding of autoimmune diseases with a specific focus on gut immunology.
• Several years of hands-on experience with rodents including live animal handling, drug administration through different routes (i.v, i.p., p.o.), blood and organ sampling and processing (colon, small intestine, spleen, lymph nodes).
• Experience with animal models of inflammatory bowel disease (IBD) and in vivo PK/PD relationships.

About the organisation
QRIOS Life Science can offer several opportunities for skilled people with a background in biochemistry, chemical engineering or science. We work with Sweden’s leading pharmaceutical and life science companies. So whether you’re interested in research, regulatory affairs, quality assurance, environmental and quality control, sales and marketing, or just want a career change, we have the job for you.

Working as a consultant suits whoever wants to get a lot of experience in a short period of time. We offer you the chance to work with well-known brands at renowned companies where you can develop your skills. If you’re looking for a world of exciting assignments and new contacts, you’ll like being a consultant.

About Astra Zeneca:
AstraZeneca is a major international healthcare company engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we are more than one of the world’s leading pharmaceutical companies - at AstraZeneca, we are proud to have a unique culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Jag söker efter en konsult för ett heltidsuppdrag hos en myndighet i Göteborg under perioden 2024-06-24 fram till 2024-08-09.
Konsulten kommer att omfattas av bestämmelserna i offentlighets- och sekretesslagen (2009:400), OSL. Konsulten kommer att få skriva under en sekretesserinran innan uppdraget påbörjas.

Dina arbetsuppgifter i huvudsak
Myndigheten vägleder kommunerna om skötsel av EU-bad i Sverige, rapporterar badvattendirektivet till Europeiska kommissionen och är värd för webbplatsen Badplatsen.

Under sommaren behöver myndigheten förstärka personalstyrkan och söker efter en sommararbetare som har en naturvetenskaplig bakgrund samt erfarenhet av att jobba serviceinriktat.
Uppdraget pågår upp till 7 veckors heltidsarbete förlagda över kontorstid: måndag till fredag. Trycket på arbetsuppgifterna varierar beroende av väder och badvilja. Huvudsakligen görs vägledningen via mejl, men sker också över telefon.

• Löpande ge vägledning runt badvatten till kommuner och allmänhet
• Löpande följa upp rapportering till webbplatsen Badplatsen
• Löpande hantera användarkonton för webbplatsen Badplatsen
• Löpande bidra till arbetet med utredningar och sammanställningar kring badvattenfrågor som uppkommer under
badsäsongen.

Du utför uppdraget i nära samarbete med medarbetare i myndighetens badvattengrupp, och interna beställare.

Vem är du?
• Högskole- eller universitetsexamen om minst 3 år med inriktning på akvatisk ekologi eller vattenvård.
• Andra möjliga inriktningar på utbildning är miljövetarprogrammet, samhällsvetenskapligt miljövetarprogram och biologiprogrammet.

• Du får gärna ha relevant erfarenhet inom t.ex. vattenförvaltning, miljökommunikation, miljöövervakning, digitalisering, arbete inom databaser, relevanta mikrobiologiska analyser, föroreningar av ytvatten, algblomning.

• God kommunikationsförmåga, serviceinriktad, självständig, stresstålig, lättlärd.

About the organisation
Detta är ett konsultuppdrag under perioden 2024-06-24 fram till 2024-08-09.
Under tiden som uppdraget är, så kommer du vara anställd av QRIOS.

Urval och intervjuer kommer ske löpande. Vänligen sök snarast.

About the position
Do you have an interest in clinical supply chain and working with external vendors and are you a person who would like to be part of a truly global team and play a key role in getting medicines to patient – then join us!

Pharmaceutical Technology and Development (PT&D) apply science and technology that turns concepts into actual medicines which help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Clinical Manufacture & Supply (C&MS;) within PT&D provides an agile and flexible end-to-end Clinical Supply Chain that manufactures, outsources and delivers supplies and services to hundreds of thousands of patients across the globe.

Responsibilities
CM&S are now looking for an External Supply Co-ordinator to join our global External Commercial Product Team in Oncology Therapy Area on a 12 month contract. We are seeking those who embrace change, show great initiative, flexibility, and a willingness to learn. As External Supply Co-ordinator, you will establish relationships with external suppliers and collaborate in teams of internal experts (e.g., Technical, Quality Assurance, Procurement) in the sourcing of services and goods required by CM&S from external suppliers in support of global projects for AstraZeneca. This role will have a specific focus on sourcing the goods and services required for sourcing commercially available product for use in AstraZeneca sponsored Clinical Trials. We would ideally like to receive applications from people with clinical supply chain and supplier management experience.

Your profile
Requirements for the role:

• BSc level education in a relevant discipline.
• Minimum 5 years’ experience of working within a Research & Development or Procurement environment and working with external providers.
• Appropriate depth of technical knowledge for the activity being sourced, to be able to fully understand any risks to delivery and make the best use of the technical experts on the team to make effective decisions.
• Experience of data analysis

Desirable for the role:

• Supplier Relationship Management skills
• Understanding quality principles and GMP requirements
• Project Management experience.
• Networking skills
• Good communication skills
• A high degree of personal credibility when interfacing with organisations internal and external to AZ.

About the organisation
QRIOS Life Science can offer several opportunities for skilled people with a background in biochemistry, chemical engineering or science. We work with Sweden’s leading pharmaceutical and life science companies. So whether you’re interested in research, regulatory affairs, quality assurance, environmental and quality control, sales and marketing, or just want a career change, we have the job for you.

Working as a consultant suits whoever wants to get a lot of experience in a short period of time. We offer you the chance to work with well-known brands at renowned companies where you can develop your skills. If you’re looking for a world of exciting assignments and new contacts, you’ll like being a consultant.

About Astra Zeneca:
AstraZeneca is a major international healthcare company engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we are more than one of the world’s leading pharmaceutical companies - at AstraZeneca, we are proud to have a unique culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.