Göteborg: Associate Principal Scientist /Senior Scientist, Bioinformatics

Hitta ansökningsinfo om jobbet Associate Principal Scientist /Senior Scientist, Bioinformatics i Göteborg. Är det intressant kan du gå vidare och ansöka jobbet. Annars kan du klicka på arbetsgivaren eller yrkesbenämningen för att se alla jobb i Göteborg inom den kategorin.

Publicerad: 2024-07-09 // Varaktighet: Heltid

We are looking for an experienced bioinformatician to join our Data Science & Bioinformatics team. You will be part of the Translational Science and Experimental Medicine (TSEM) department in the Respiratory and Immunology therapeutic area. As a department we promote an open and collaborative atmosphere, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective targets and the right patient populations.

This role is located at one of our sites in either Gothenburg (Sweden) or Gaithersburg (US).

Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions. We harness data science & AI to fast-forward our research. Making sure work born in a lab can make a real difference, every day, impacting patients' lives across the world.

What you will do
In this role, you will work in a highly cross-functional and thriving environment together with specialists in sequencing, immunological and respiratory disease, as well as with other data science & bioinformatics experts.

For this role we are looking for an outstanding bioinformatician to enable translational science via integration of large-scale omics, clinical data, real world evidence and literature data to deliver precision medicine within our pipeline. You´ll be identifying novel targets, biomarkers and patient sub-groups through innovative data analysis approaches including utilization of clinical cohort omics data sets.

You will contribute to the identification of transformational precision medicine propositions to deliver life changing medicines to patients. You will be responsible for planning, performing and interpreting your analysis and communicate results. By applying state-of-the-art analytical methods, you will maximise the knowledge extrapolated from our growing omics data in complex diseases impacting the project progression and future treatment options for patients with unmet medical needs.

Depending on your previous experience, your initial career level will be an Associate Principal Scientist or Senior Scientist.

Essential for the role

* MSc with extensive industry experience (4+ years), or preferably, PhD or equivalent in bioinformatics, data science, statistics, biostatistics, mathematics, or another similar subject area.
* Substantial experience and proficiency in large-scale omics data analysis, integration and interpretation is a requirement. Omics include transcriptomics, single cell, spatial transcriptomics, proteomics (Olink, LC/MS), genomics, and other types of next generation sequencing (NGS) such as chromatin state approaches.
* Excellent coding skills in Python, R, or similar language appropriate for large scale omics analysis and experience with version control (Git/Bitbucket).
* A good understanding of life sciences and how omics data can be utilised to derive biological insight is required. Experience from applying this across different phases of pharmaceutical discovery and development is a preference.
* Outstanding communication and collaboration skills, both with experts and non-experts, and with peers as well as stakeholders is expected. Our team is a collaborative group, so the ability to be comfortable working in a goal-oriented way, with a team focused approach is central to be successful in the role.
* We believe you also have a high degree of independence and a proactive and delivery focused approach.

Desirable for the role

* Experience in pharmaceutical R&D and/or Post-doc experience.
* Molecular understanding of human diseases, patient stratification and biomarker-based endpoint generation, preferentially in respiratory and immunological disorders.
* Understanding of in vitro and in vivo model systems and assessment of translatability.
* Track record of applying bioinformatic analysis to drive projects in drug discovery or development in an industrial or academic setting. Familiarity with network analysis.
* Broad experience applying machine learning methods such as random forests, clustering, dimensionality reduction in a systems biology or systems medicine context.

* Working in a Linux environment, ideally with experience of cluster or cloud computing (e.g. AWS or Azure).
* Experience from leading projects with internal groups/external collaborators.

* Experience working within cross-functional teams.

Work policy
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

What's next?
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application (including CV and cover letter), no later than July 24, 2024. If you're curious to know more about the position, please get in touch with hiring manager Greet De Baets at greet.debaets1@astrazeneca.com.

Where can I find out more?
Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/
Follow AstraZeneca on Instagram: https://www.instagram.com/astrazeneca_careers/?hl=en
Read more about BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

Alla platsannonser →

Andra jobb i Göteborg som Biomedicinsk analytiker

Nedan visas andra jobb i Göteborg som Biomedicinsk analytiker.

Manager, Clinical Regulatory Writing (CVRM)

Läs mer Jul 19
Are you ready to make a meaningful impact on people's lives with life-changing medicines? We are seeking a Manager, Clinical Regulatory Writing (CReW) to join our Biopharmaceuticals R&D team. This role offers the opportunity to provide expert communications leadership to drug projects and author strategically important clinical-regulatory documents. You will be instrumental in supporting the Company's CVRM therapeutic areas in all phases of clinical development. Our vision is to be an industry leading organization driving strategic communication excellence to achieve successful submissions and approvals.



What you'll do

As a Manager, Clinical Regulatory Writing, you will lead authorship and ensure the timely delivery of high-quality clinical-regulatory documents. It is your task to ensure that relevant regulatory, technical, and quality standards are achieved, and that relevant processes and best practice are applied. It is important to have the ability to balance multiple tasks in parallel, potentially across several drug projects, and deliver on priorities.



You are expected to drive the clinical interpretation of data and information and condense it into clear, concise and accurate messages that address customer information requirements. As well as provide critical review of documents for correctness, clarity, completeness and compliance.



It will require you to proactively collaborate with other functions during document development, including, as needed, with external service providers/contractors. As part of a clinical delivery team, you will provide communications support to projects, establish communication standards and best practice, and continuously advocate for quality and efficiency.



Essential for the role

- Life sciences degree in an appropriate subject area.

- Experience in the medical/regulatory writing field gained in a pharmaceutical/biotech industry or CRO environment.

- Understand drug development and communication process from development, launch, and life cycle management.

- Knowledge of the technical and regulatory requirements related to the role.

- Excellent verbal and written communication skills in English.

- Flexibility in adapting to changing circumstances or new information.

- Ability to work independently with support of more senior members and/or as part of a team.



When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.



At AstraZeneca, we believe in turning our drug development strategies into reality. We work at all stages of development to translate our life-changing science into medicines to get the best results for AstraZeneca, patients in need and healthcare professionals. We are a diverse and open-minded team harnessing our different skills and experiences. Our differences enable us to explore new ideas and ways of doing things. It keeps us on our toes and excited for what's next. We are part of the solution, involved in key discussions, in our role we act as both a drug developer and Regulator. We think broadly about patients and what it takes to prevent and treat diseases to develop progressive solutions.



Are you ready to join a team with deep specialist knowledge and Regulatory expertise? We welcome your application no later than 2nd august, 2024!

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Biomedicinsk analytiker med inriktning mot forskning - välkommen till oss!

Läs mer Jul 1
Tillsammans utvecklar vi Sahlgrenska Universitetssjukhuset för en hållbar framtid. Vi ställer om hälso- och sjukvården med målet att vara Europas ledande universitetssjukhus 2032. Tillsammans med patienterna arbetar vi för kvalitet, tillgänglighet, patientsäkerhet, forskning, utbildning och innovation på högsta nivå – i ett sammanhållet hälso- och sjukvårdssystem. Sahlgrenska Universitetssjukhuset bedriver världsledande sjukvård, forskning, utbildning och innovation som efterfrågas nationellt och internationellt. Vår vision och våra mål tar sikte mot en vård av högsta kvalitet, där patienten är alltid är i fokus.



Om verksamheten

SCAPIS (Swedish CardioPulmonary bioImage Study) är en unik svensk befolkningsstudie som har genomfört omfattande undersökningar på ca 30 000 kvinnor i män i åldern 50–64 år.

Syftet med studien är att kunna identifiera individuella risker för sjukdom kopplade till hjärta-kärl och lungor och behandla innan sjukdom uppstår. SCAPIS leds och drivs i samverkan av forskare från universiteten och universitetssjukhusen i Göteborg, Linköping, Malmö, Stockholm, Uppsala och Umeå. Huvudfinansiär av studien är Hjärt- Lungfonden med betydande bidrag från Knut och Alice Wallenbergs stiftelse, Vinnova, Vetenskapsrådet samt de deltagande universitetssjukhusen och universiteten. Som ett nästa steg i SCAPIS kommer hälften av deltagarna, det vill säga 15 000, från studien bjudas in för att undersökas på nytt (SCAPIS 2). Därmed samlas ny information in som ger möjlighet att följa och utreda kärlens och lungornas åldrande över tid. 

Arbetsuppgifter

Att jobba hos oss är ett varierande arbete där studiedeltagaren står i fokus. Arbetsuppgifterna är fokuserade på att utföra undersökningar som innefattar andningsfysiologi. Även en hel del administrativa uppgifter ingår i tjänsten.

Om dig

Vi söker dig som är biomedicinsk analytiker med svensk legitimation. Erfarenhet av arbete inom klinisk fysiologi med inriktning mot andningsfysiologi är meriterande. Kompetenser vi värdesätter är att du är noggrann och ansvarsfull. Du har god samarbetsförmåga, en uttalad servicekänsla och kan arbeta både självständigt och i grupp. Eftersom undersökningar kan vara av akut karaktär önskar vi att du är strukturerad och har en god problemlösningsförmåga. Arbetet kräver att du kan uttrycka dig väl på svenska i tal och skrift. Vi lägger stor vikt vid personlig lämplighet.

Tidigare arbete inom klinisk forskning är meriterande. Meriterande är också god datorvana och mer specifikt arbeta i datorsystem för att registrera forskningsinformation och boka deltagare. GCP utbildning är ett krav.

Varmt välkommen med din ansökan!

Möt några av våra medarbetare - Sahlgrenska Universitetssjukhuset
Om Västra Götalandsregionen
Västra Götalandsregionen finns till för människorna i Västra Götaland. Vi ser till att det finns god hälso- och sjukvård för alla. Vi arbetar för en hållbar utveckling och tillväxt, bra miljö, förbättrad folkhälsa, ett rikt kulturliv och goda kommunikationer i hela Västra Götaland.
Västra Götalandsregionen arbetar aktivt för att digitalisera fler arbetssätt. För att vara en del av den digitala omvandlingen har du med dig grundläggande färdigheter och kan använda digitala verktyg och tjänster. Du kan söka information, kommunicera, interagera digitalt, är riskmedveten och har motivation att delta i utvecklingen för att lära nytt.
Västra Götalandsregionen krigsplacerar alla tillsvidareanställda medarbetare.


Vill du veta mer om Västra Götalandsregionen kan du besöka vår introduktion till nya medarbetare på länken https://www.vgregion.se/introduktion.  Du kan även läsa mer i presentation om https://mellanarkiv-offentlig.vgregion.se/alfresco/s/archive/stream/public/v1/source/available/sofia/rs4011-467070786-672/surrogate.




Ansökan
Västra Götalandsregionen ser helst att du registrerar din ansökan via rekryteringssystemet. Om du som sökande har frågor om den utannonserade tjänsten eller av särskilda och speciella skäl inte kan registrera dina uppgifter i ett offentligt system - kontakta kontaktperson för respektive annons.


Till bemannings-, förmedlings- och rekryteringsföretag och till dig som är försäljare:
Vi undanber oss vänligen men bestämt direktkontakt med bemannings-, förmedlings- och rekryteringsföretag samt andra externa aktörer och försäljare av ytterligare jobbannonser. Västra Götalandsregionen har upphandlade avtal.

Ansök nu

timanställd undersköterska/biomedicinsk analytiker

Läs mer Jun 2
Göteborgskliniken söker en engagerad och kvalificerad timanställd undersköterska/biomedicinsk analytiker för att utöka vårt team!


Om oss:


Göteborgskliniken är en privatmottagning belägen i hjärtat av Göteborg, specialiserad på preventiv sjukvård. Vi är stolta över att erbjuda högkvalitativ vård och service med fokus på förebyggande insatser för att förbättra och upprätthålla hälsa. Vårt team består av kompetenta läkare, sjuksköterskor, undersköterskor och biomedicinska analytiker som arbetar tillsammans för att säkerställa bästa möjliga vård. Med patientcentrerad vård och kontinuerlig utveckling som våra ledstjärnor, strävar vi alltid efter att förbättra och anpassa våra tjänster efter våra patienters behov.


Arbetsbeskrivning:


Vi söker nu en timanställd undersköterska/biomedicinsk analytiker som vill bli en del av vårt dynamiska team. Du kommer att arbeta i en stimulerande miljö med varierande arbetsuppgifter inom preventiv sjukvård.


Arbetsuppgifter inkluderar bland annat:


Provtagning och analys
Dokumentation och journalhantering
Administrativa uppgifter
Bidra till att upprätthålla en ren och trygg vårdmiljö



Kvalifikationer:


Legitimerad undersköterska eller biomedicinsk analytiker
God kommunikationsförmåga och samarbetsförmåga
Förmåga att arbeta självständigt och ta initiativ
Flexibilitet och en positiv inställning
Vi välkomnar även ansökningar från duktiga studenter och sjuksköterskestudenter



Vi erbjuder:


En möjlighet att vara en del av ett professionellt och vänligt team
En stimulerande arbetsmiljö med varierande arbetsuppgifter
Flexibla arbetstider



Ansökan:


Låter detta som en spännande möjlighet för dig? Skicka ditt CV och personliga brev till info@goteborgskliniken.se. Märk ansökan med “Timanställd undersköterska/biomedicinsk analytiker”.


Vi ser fram emot din ansökan och möjligheten att välkomna dig till vårt team på Göteborgskliniken!


Göteborgskliniken
Södra Allégatan 12, Göteborg
Telefon: 031-761 77 00
E-post: info@goteborgskliniken.se
Hemsida: www.göteborgskliniken.se

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Biomedicinsk Analytiker välkomnas till Immunhematologi!

Läs mer Jun 12
Tillsammans utvecklar vi Sahlgrenska Universitetssjukhuset för en hållbar framtid. Vi ställer om hälso- och sjukvården med målet att vara Europas ledande universitetssjukhus 2032. Tillsammans med patienterna arbetar vi för kvalitet, tillgänglighet, patientsäkerhet, forskning, utbildning och innovation på högsta nivå – i ett sammanhållet hälso- och sjukvårdssystem. Sahlgrenska Universitetssjukhuset bedriver världsledande sjukvård, forskning, utbildning och innovation som efterfrågas nationellt och internationellt. Vår vision och våra mål tar sikte mot en vård av högsta kvalitet, där patienten är alltid är i fokus.

Regional laboratoriemedicin tillhör Sahlgrenska Universitetssjukhuset, område 4 och har ett tydligt samordningsuppdrag för hela Västra Götalandsregionen. Organisationen består av de laboratoriemedicinska verksamheterna på Södra Älvsborgs sjukhus, Sahlgrenska Universitetssjukhuset, Sjukhusen i väster och i NU-sjukvården.



Om verksamheten

Klinisk Immunologi och Transfusionsmedicin (KITM) är organiserad i 6 enheter i Västra Götalandsregionen.

Enheten Immunhematologi har cirka 30 medarbetare och ansvarar för bestämning av patienters och blodgivares blodgrupper. Vi undersöker också huruvida patienter har antikroppar mot olika blodkroppar. Detta för att säkerställa att transfusion av blodkomponenter görs på ett patientsäkert sätt och för att utreda de fall då patienten av någon anledning reagerat negativt på en transfusion. Metoderna som används är främst serologiska tester men verksamheten utökas även med molekylärbiologiska metoder. Vi är ackrediterade, arbetar kvalitetssäkrat och går en spännande framtid till mötes.

Vi arbetar med ständiga förbättringar för att möta en växande verksamhet och nya avancerade tekniker. Hos oss arbetar du med korta eller längre utredningar, både planerade och akuta. Enheten har under de senaste åren infört nya moderna utrustningar för att effektivisera analysflödet. Enheten är bemannad dygnet runt och verksamheten bedrivs både på Östra sjukhuset samt på Sahlgrenska sjukhuset.

Arbetsuppgifter

Du kommer att ingå i ett härligt gäng och utföra både akuta -och rutinanalyser inför blodtransfusioner. Analyserna innefattar blodgrupperingar, BAS-tester samt utredningar. Du kommer att arbeta med varierande arbetsuppgifter och arbetstempo beroende på vad som händer ute i samhället. Det du gör kommer direkt att vara avgörande för patientens vård. Det finns även möjlighet att delta i utbildningar, kurser samt arbeta i nya projekt.

Om dig

För att trivas hos oss bör du ha mycket god förmåga att kunna prioritera i akuta situationer med högt tempo och tycka om att ta egna initiativ. Du är strukturerad och har en god kommunikationsförmåga, du uppskattar att arbeta i nära samarbete med kollegor samt förstår vikten av att arbeta på ett kvalitetssäkert sätt.

Då arbetet innehåller manuella moment behöver du vara mycket noggrann, ha bra handlag och stor förmåga att planera ditt arbete, och med en serviceinriktad attityd och ett stort engagemang bidrar du till förbättringsarbetet på sektionen.

Stor vikt läggs vid personlig lämplighet.

Välkommen med din ansökan!

Möt några av våra medarbetare - Sahlgrenska Universitetssjukhuset

Vill du veta mer om vilka möjligheter du har att utvecklas tillsammans med oss på Sahlgrenska Universitetssjukhuset, gå in via länk: Karriärutvecklingsmodellen - Sahlgrenska Universitetssjukhuset
Om Västra Götalandsregionen
Västra Götalandsregionen finns till för människorna i Västra Götaland. Vi ser till att det finns god hälso- och sjukvård för alla. Vi arbetar för en hållbar utveckling och tillväxt, bra miljö, förbättrad folkhälsa, ett rikt kulturliv och goda kommunikationer i hela Västra Götaland.
Västra Götalandsregionen arbetar aktivt för att digitalisera fler arbetssätt. För att vara en del av den digitala omvandlingen har du med dig grundläggande färdigheter och kan använda digitala verktyg och tjänster. Du kan söka information, kommunicera, interagera digitalt, är riskmedveten och har motivation att delta i utvecklingen för att lära nytt.
Västra Götalandsregionen krigsplacerar alla tillsvidareanställda medarbetare.


Vill du veta mer om Västra Götalandsregionen kan du besöka vår introduktion till nya medarbetare på länken https://www.vgregion.se/introduktion.  Du kan även läsa mer i presentation om https://mellanarkiv-offentlig.vgregion.se/alfresco/s/archive/stream/public/v1/source/available/sofia/rs4011-467070786-672/surrogate.




Ansökan
Västra Götalandsregionen ser helst att du registrerar din ansökan via rekryteringssystemet. Om du som sökande har frågor om den utannonserade tjänsten eller av särskilda och speciella skäl inte kan registrera dina uppgifter i ett offentligt system - kontakta kontaktperson för respektive annons.


Till bemannings-, förmedlings- och rekryteringsföretag och till dig som är försäljare:
Vi undanber oss vänligen men bestämt direktkontakt med bemannings-, förmedlings- och rekryteringsföretag samt andra externa aktörer och försäljare av ytterligare jobbannonser. Västra Götalandsregionen har upphandlade avtal.

Ansök nu

Andra jobb i Göteborg från Astrazeneca AB

Nedan visas andra jobb i Göteborg från Astrazeneca AB .

Preclinical and Translational PK & PKPD Scientist

Biomedicinare
Läs mer Jul 2
Are you a Scientist with a flair for mathematical modelling and knowledge of pharmacokinetics and pharmacodynamics? Are you passionate about PKPD and model-based drug discovery? Would you like to apply your knowledge in a global company that follows the science and turns ideas into life-changing medicines? If you are ready to drive innovation and make meaningful impacts in the PKPD field, then you could be the new colleague we are looking for to be part of the development of future treatment within respiratory and immunology.



Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are now recruiting a highly skilled and passionate scientist with expertise in mathematical modelling, preferably applied in the field of pharmacokinetics-pharmacodynamics (PKPD), to join the Drug Metabolism and Pharmacokinetics (DMPK) team of project leads within the Early Respiratory and Immunology (R&I) therapeutic area at AstraZeneca in Gothenburg, Sweden.



Early R&I is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and life-cycle management. At AstraZeneca we are proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients.



This position will be on-site in Gothenburg, Sweden and will not have the ability to be located remotely. The position can be filled at Senior Scientist, Associate Principal Scientist (APS) or Principal scientist (PS) level, depending on background, experience and skills.



What you'll do
As a PKPD scientist you will be involved in many tasks related to PK and PKPD assessment, modelling and translation. You will represent the department in highly collaborative, cross-disciplinary project teams in early R&I across a broad range of drug modalities from target identification to life cycle management. We believe that you have solid, hands-on experience of PKPD modeling and that you will be able to provide expert advice and interpretation of complex drug discovery data.



Main Duties and Responsibilities include:
* Build appropriate mathematical models (e.g. traditional PKPD modelling, non-linear effects modelling, quantitative systems pharmacology) and perform simulations of human PK and PD based on preclinical (in vitro/in vivo) data and literature data on relevant drugs to deliver a translational quantitative PKPD strategy in projects.
* Integrate the appropriate data to predict human pharmacokinetics, efficacious human drug exposure, human longitudinal response (e.g. biomarker and disease effects), and human dosing regimen. This is done in close collaboration with other functions (biologists, safety scientists, clinical pharmacologist and clinical pharmacometricians).
* Inform and influence the design of preclinical PK and PKPD studies to answer relevant pharmacological questions and report results and interpretations and contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies.
* Communicate scientific progress to internal and external stakeholders



Essential for the role
* PhD/MSc in mathematics, pharmaceutical sciences, pharmacology, biomedical engineering, biochemistry, chemistry or related field, with substantial relevant pharmaceutical industry experience.
* Solid understanding of PKPD and hands on experience of mathematical modelling (e.g. empirical PKPD models, in vitro-in vivo translation, non-linear mixed effects models, quantitative systems pharmacology (QSP) models).

* Experience working in cross-functional project teams with a proactive and collaborative mindset and excellent communication skills.
* Working knowledge of PKPD software (e.g. Phoenix WinNonlin, Matlab, R, NONMEM, or similar) and the ability to critically assess PKPD data.
* Tried scientific leadership and ability to mentor junior colleagues
* Scientific leadership evidenced by a publication track record and ability to independently lead the drafting and review of publication manuscripts.
* Excellent interpersonal skills



Why AstraZeneca?
As we know employees are critical to our current and future success, we are dedicated to being a great place to work and we offer competitive benefits and services. You are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There is no better place to make a difference to medicine, patients and society. AstraZeneca has an inclusive culture that champions diversity and collaboration - always committed to lifelong learning, growth and development.



What's next?
This is an exciting opportunity for a talented modeller to join a strong, dynamic team and support the portfolio of a major pharmaceutical company that has science at its heart whilst being based in the beautiful city of Gothenburg, Sweden.



If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until 31 August, 2024. For more information about the position, please contact recruiting manager Nina Lawrence at Nina.Lawrence@astrazeneca.com



Note: Due to the summer vacation period in Sweden, the screening process may take a bit longer than usual. Please bear with us, and we will get back to you as soon as possible when we are back mid/end of August.

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DMPK Project Leader - Early Respiratory & Immunology

Biomedicinare
Läs mer Jun 26
Are you an experienced scientist with expertise in pharmacokinetics, pharmacology and drug metabolism (DMPK)? Would you like to apply your expertise in a global company that follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!

Our team is growing, and we are now looking for a motivated individual with experience in Biologics and/or small molecule drug development and PKPD, to join us as a DMPK Project Leader, from candidate selection to registration and beyond. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress.

This position will be on-site at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, and will not have the ability to be located remotely.

Respiratory & Immunology (R&I) is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function, with research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management.

What you'll do?
With a true passion for drug discovery you will support our portfolio within the R&I therapeutic area as a subject matter expert. In the DMPK project lead role you will work collaboratively with project representatives from other disciplines. These may include biology, safety , clinical pharmacology, pharmaceutical sciences, antibody Discovery/Protein Engineering and medicinal chemistry, where your task is to influence candidate profiling by providing the necessary DMPK support for clinical investigations.

It is your responsibility to ensure delivery of all DMPK related activities throughout the value chain in accordance with regulatory requirements. These include preclinical PK experiments, in vitro ADME and biotransformation to yield pharmacokinetic understanding. Furthermore, assisting design of pharmacodynamic studies that ultimately delivers a pharmacological assessment underpinning human dose prediction and emerging clinical experience.

You will work as the development DMPK representative on project teams from candidate selection to registration and beyond. We believe that you have a solid understanding of DMPK, a working knowledge of pharmacology, and that you will be able to provide expert advice and interpretation of complex nonclinical and clinical data.

Main duties and responsibilities;

*

Communicate scientific progresses both externally and internally
*

Deliver DMPK input and data to projects within agreed timelines and to the right quality
*

Responsible for delivering and produce the nonclinical pharmacokinetic documentation to support clinical progression
*

Apply an understanding of DMPK to support/influence compound profiling, project progression and project strategy
*

Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
*

Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
*

Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities
*

Prepare clear presentations related to the above for internal governance bodies



Your level of professional experience will be relevant for your initial career level (Senior Scientist, Associate Principal Scientist or Principal Scientist).



?Essential for the role

*

PhD or equivalent experience in a relevant field
*

Expert in DMPK sciences with profound knowledge of drug discovery and development processes
*

Broad experience in biologics drug development (PK & Bioanalysis)
*

Have PK modelling skills, experience of human PK and dose prediction, as well as an understanding of disease biology and PKPD
*

Experience with regulatory submissions for biologics and/or small molecules
*

Knowledge of all DMPK assays including the use of in silico tools for PK prediction
*

Experience in project leadership
*

Collaborative mindset and a team player
*

Proactive in providing expert support to project team and excellent communication skills


Work policy
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

What's next!
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until August 31, 2024. For more information about the position, please contact recruiting manager Lassina Badolo at Lassina.Badolo@astrazeneca.com

Note: Due to the summer vacation period in Sweden, the screening process may take a bit longer than usual. Please bear with us, and we will get back to you as soon as possible when we are back mid/end of August.?

Where can I find out more?
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

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Manager, Clinical Regulatory Writing (CVRM)

Biomedicinsk analytiker/BMA
Läs mer Jul 19
Are you ready to make a meaningful impact on people's lives with life-changing medicines? We are seeking a Manager, Clinical Regulatory Writing (CReW) to join our Biopharmaceuticals R&D team. This role offers the opportunity to provide expert communications leadership to drug projects and author strategically important clinical-regulatory documents. You will be instrumental in supporting the Company's CVRM therapeutic areas in all phases of clinical development. Our vision is to be an industry leading organization driving strategic communication excellence to achieve successful submissions and approvals.



What you'll do

As a Manager, Clinical Regulatory Writing, you will lead authorship and ensure the timely delivery of high-quality clinical-regulatory documents. It is your task to ensure that relevant regulatory, technical, and quality standards are achieved, and that relevant processes and best practice are applied. It is important to have the ability to balance multiple tasks in parallel, potentially across several drug projects, and deliver on priorities.



You are expected to drive the clinical interpretation of data and information and condense it into clear, concise and accurate messages that address customer information requirements. As well as provide critical review of documents for correctness, clarity, completeness and compliance.



It will require you to proactively collaborate with other functions during document development, including, as needed, with external service providers/contractors. As part of a clinical delivery team, you will provide communications support to projects, establish communication standards and best practice, and continuously advocate for quality and efficiency.



Essential for the role

- Life sciences degree in an appropriate subject area.

- Experience in the medical/regulatory writing field gained in a pharmaceutical/biotech industry or CRO environment.

- Understand drug development and communication process from development, launch, and life cycle management.

- Knowledge of the technical and regulatory requirements related to the role.

- Excellent verbal and written communication skills in English.

- Flexibility in adapting to changing circumstances or new information.

- Ability to work independently with support of more senior members and/or as part of a team.



When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.



At AstraZeneca, we believe in turning our drug development strategies into reality. We work at all stages of development to translate our life-changing science into medicines to get the best results for AstraZeneca, patients in need and healthcare professionals. We are a diverse and open-minded team harnessing our different skills and experiences. Our differences enable us to explore new ideas and ways of doing things. It keeps us on our toes and excited for what's next. We are part of the solution, involved in key discussions, in our role we act as both a drug developer and Regulator. We think broadly about patients and what it takes to prevent and treat diseases to develop progressive solutions.



Are you ready to join a team with deep specialist knowledge and Regulatory expertise? We welcome your application no later than 2nd august, 2024!

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Product Manager/Owner Biosample, Evinova

Civilingenjör, bioteknik
Läs mer Jul 12
Evinova is a new innovative health-tech business with the ambition to deliver industry-leading digital health solutions to the wider healthcare community, to improve patient experience and outcomes. It is an independent company, part of the AstraZeneca group.

The Product Manager will lead our work to design and develop a state-of-the-art platform for deployment of patient and site facing technologies in clinical trials for Evinova customers. The role will work with other SMEs within and outside Evinova to deliver innovative approaches to transform the user experience, deploy products and support the onboarding of new studies in an efficient way securing the highest quality and speed. You will also be responsible for mapping the external technical landscape and understand similar products pro's and con's from a patient/HCP/Sponsor perspective. You will work in a team of Product Managers/Owners to jointly deliver a flexible product that covers most aspects of patient and site staff interactions in a clinical trial.

The Product Manager will focus on solutions for biosample management to reduce burden on site while improving quality in information collected. This includes, but is not limited to, tracking status from point of collection to analysis and integration with other key system in this value flow.

Responsibilities:

You will:

* Lead work to design and deliver the required solutions for management of biosamples at the site to deliver a transformed experience for site staff while improving the information flow.
* Engage with SMEs to identify end user, sponsor or regulatory needs for an optimal management of biosamples.
* Work closely with the other Product Managers/Owners within Unified Trials as well as other products in Evinova.
* Work as part of a cross-functional agile delivery team in building and executing an implementation plan. Responsible for stimulating conceptual thinking and creativity and challenging the status quo for continuous improvement.
* You will need a deep understanding of business needs and users' needs to craft the processes, solution and prioritise improvement needs.
* Deliver high-quality, hypothesis tested, business requirements, functional specifications, business processes, and system rules.
* Understand the current landscape of similar technical solutions and what their strengths and development areas are.
* Deliver effective recommendations for prioritisation regarding the product backlog items in order to deliver maximum outcome with minimum input in line with business priorities.
* Review, analyse and evaluate business systems/processes and user-needs while serving as the key link between digital and IT development teams.
* Act as a change agent during the global roll-out of new technologies - embed new tools and technologies into the business and measure success. Provide leadership for those leading the day-to-day implementation of new tools through to completion.
* Help build a learning organisation: ensure that any learning associated with the programs is shared within the Evinova.

Essential Requirements:

* 3 or more years experience with management of biosamples or related areas
* 3 or more years of Product Management/Owner experience, preferably with larger complex solutions in clinical research.
* Knowledge about Clinical trial delivery and Pharmaceutical drug development
* Awareness of GCP, 21 CFR part 11, relevant guidelines from ISPOR, ISOQOL, FDA, EMA
* Proven ability to work collaboratively in a cross functional setting with internal as well as external partners
* Proven ability to challenge the status quo, take ownership and holds self and others accountable
* Senior Stakeholder management skill with together with proven negotiation, collaboration and interpersonal leadership skills
* Effective problem and conflict solving skills
* Excellent written and verbal communication skills, with the ability to deal with ambiguity and create clarity
* Passion for Customers, representing the needs of multiple customers in decision making.

Desirable:

* Knowledge about the Clinical Research eco-system and key solutions like Labsystems, EDC, etc.
* Thrives in a fast-paced work environment, comfortable with complexity and uncertainty at times, lots of humour, dedication to deliver outcomes and motivated by the opportunity to rethink our approach to healthcare.
* Comfort and skills operating in a heavily matrixed organizations with excellent skills and intuition to manage the needs of various partners.
* Ability to rapidly grasp concepts and excellent ability to handle complexity by simplifying it and providing clear directions to the team
* Ability to manage and influence strategically and persuade tactfully, to acquire desired outcomes while maintaining effective, positive, organizational relationships

* Comprehensive understanding of dynamics affecting the pharmaceutical industry and needs for transformation

* Ability to work globally including international travel

Join us on our journey of building a new kind of health tech business to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting-edge methods, and bringing unexpected teams together. Interested? Come and join our journey.

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Product Manager/Owner Automation & Tooling, Evinova

Biomedicinare
Läs mer Jul 12
Evinova is a new innovative health-tech business with the ambition to deliver industry-leading digital health solutions to the wider healthcare community, to improve patient experience and outcomes. It is an independent company, part of the AstraZeneca group.

The Product Manager will lead our work to design and develop a state-of-the-art platform for deployment of patient and site facing technologies in clinical trials for Evinova customers. The role will work with other SMEs within and outside Evinova to deliver innovative approaches to transform the user experience, deploy products and support the onboarding of new studies in an efficient way securing the highest quality and speed. You will also be responsible for mapping the external technical landscape and understand similar products pro's and con's from a patient/HCP/Sponsor perspective. You will work in a team of Product Managers/Owners to jointly deliver a flexible product that covers most aspects of patient interactions in a clinical trial.

The Product Manager will focus on tooling and automation with the purpose of reducing manual work and timelines for bringing new clinical trials onto the Evinova platform. This includes, but is not limited to, areas such as Content Management, Configuration Management, and Ethics Committee documentation.

Responsibilities:

You will:

* Lead work to design and deliver tools to configure, deploy and deliver the products in an efficient way.
* Design systems that facilitate non-code configuration of products, with the goal of empowering Evinova customers to independently deploy products, minimizing the need for extensive Evinova staff intervention.
* Engage with SMEs to spearhead enhancements to enable the Deployment organization's objectives.
* Work closely with the other Product Managers/Owners within Unified Trials as well as other products in Evinova.
* Work as part of a cross-functional agile delivery team in building and executing an implementation plan. Responsible for stimulating conceptual thinking and creativity and challenging the status quo for continuous improvement.
* You will need a deep understanding of business needs and users' needs to craft the processes, solution and prioritise improvement needs.
* Deliver high-quality, hypothesis tested, business requirements, functional specifications, business processes, and system rules.
* Understand the current landscape of similar technical solutions and what their strengths and development areas are.
* Deliver effective recommendations for prioritisation regarding the product backlog items in order to deliver maximum outcome with minimum input in line with business priorities.
* Review, analyse and evaluate business systems/processes and user-needs while serving as the key link between digital and IT development teams.
* Act as a change agent during the global roll-out of new technologies - embed new tools and technologies into the business and measure success. Provide leadership for those leading the day-to-day implementation of new tools through to completion.
* Help build a learning organisation: ensure that any learning associated with the programs is shared within the Evinova.

Essential Requirements:

* 3 or more years experience with scaling of other products
* Well-developed Product Management skills
* Knowledge about Clinical trial delivery and Pharmaceutical drug development
* Awareness of GCP, 21 CFR part 11, relevant guidelines from ISPOR, ISOQOL, FDA, EMA
* Proven ability to work collaboratively in a cross functional setting with internal as well as external partners
* Proven ability to challenge the status quo, take ownership and holds self and others accountable
* Senior Stakeholder management skill with together with proven negotiation, collaboration and interpersonal leadership skills
* Effective problem and conflict solving skills
* Excellent written and verbal communication skills, with the ability to deal with ambiguity and create clarity
* Passion for Customers, representing the needs of multiple customers in decision making.

Desirable:

* Thrives in a fast-paced work environment, comfortable with complexity and uncertainty at times, lots of humour, dedication to deliver outcomes and motivated by the opportunity to rethink our approach to healthcare.
* Comfort and skills operating in a heavily matrixed organizations with excellent skills and intuition to manage the needs of various partners.
* Ability to rapidly grasp concepts and excellent ability to handle complexity by simplifying it and providing clear directions to the team
* Ability to manage and influence strategically and persuade tactfully, to acquire desired outcomes while maintaining effective, positive, organizational relationships

* Comprehensive understanding of dynamics affecting the pharmaceutical industry and needs for transformation

* Ability to work globally including international travel

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Join us on our journey of building a new kind of health tech business to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting-edge methods, and bringing unexpected teams together. Interested? Come and join our journey!

Ansök nu

Translational Scientist - Early Respiratory & Immunology

Biomedicinare
Läs mer Jul 18
Are you a curious Scientist who wants to join a team working with outstanding science that have a direct impact for patients? Do you also want to contribute to our larger purpose with great colleagues by your side working in a collaborative, global environment? If yes, welcome to join AstraZeneca!



We are now looking for a Translational Scientist to join our Precision Medicine Discovery and Development team. This role is based at our site in Gothenburg, Sweden.

The Early Respiratory and Immunology (Early R&I) Translational Science and Experimental Medicine (TSEM) department is a fast-paced environment, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population, and to close the gap between bench science and bedside clinical practice.



A key role of Precision Medicine Discovery and Development is to lead the development of precision medicine in immunological and respiratory diseases, driving patient stratification and delivering translational clinical validation, underpinned by the understanding of disease relevant pathways and drivers.



What you'll do?
The Translational Scientist is accountable as member of the Translational Science team for the development and optimisation of molecular biology techniques and biomarker assays to enable precision medicine and target validation strategies. Continuous collaboration with Translational Science Leads, Bioscience, and Biomarker Discovery colleagues will be essential to qualify relevant experimental techniques, disease models and biomarkers according to projects requirements. This is a laboratory role, requiring flexibility to ensure all experimental aspects of the projects are supported according to timelines.



This is a key scientific laboratory role, where you will be focusing on:



* Enabling precision medicine strategies to select the patients most likely to benefit from our medicines by developing biomarker assays and analysing biomarkers in experimental medicine cohorts
* Building mechanistic understanding of targets and diseases through setting up and execution of novel molecular biology techniques
* Establishing and using advanced human disease models to deliver human target validation data and early target engagement assessments
* Identifying Proof of Mechanism (PoM) biomarkers to demonstrate target engagement in clinical studies

Essential for the role:
* Bachelor's degree with a strong experimental drive and background in relevant scientific field
* Experience in a pharmaceutical or biotechnology industry setting
* Broad understanding of relevant technologies and methodologies along with excellent laboratory skills and ability to experimentally address key scientific questions
* Experience in setting up novel molecular biology techniques
* Experience in working with human biological samples
* Understanding of the Immunology and/ or Respiratory therapy area and disease biology, including related molecular pathways and mechanisms
* Skilled in hypothesis forming and testing
* Skilled in data analysis, interpretation and archiving
* Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects
* Proven written, oral, presentation and interpersonal skills



Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we're proud to have an outstanding workplace culture that encourages innovation, entrepreneurship, and collaboration through scientific research. Employees are empowered to express diverse perspectives and are made to feel valued, energised and rewarded for their ideas and creativity.



What's next?
If you are ready to make a difference - apply today, and we'll make it happen together!

Ansök nu